Sleep apnea in people with Down syndrome: Causes and effects of physical activity?

Nguyen, Duy-Thai; Bricout, Véronique-Aurélie; Tran, Hong-Tram; Pham, Vuong-Hung; Duong‐Quy, Sy

doi:10.3389/fneur.2023.1123624

Cited by 3 publications

(2 citation statements)

References 77 publications

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“…The repercussions of sleep disruption caused by sleep apnea are highly significant, particularly in terms of neurocognitive and cardiovascular effects. This, in turn, can result in a diminished life expectancy and quality of life within this population [66]. Early interventions in the oral cavity that influence jaw growth and tongue position may play a crucial role in mitigating the severity of sleep apnea.…”

Section: Oral Function In Down Syndromementioning

confidence: 99%

A Comprehensive Review of the Relationship Between Oral Health and Down Syndrome

Botero,

Rodríguez-Medina,

Amaya-Sanchez

et al. 2024

Curr Oral Health Rep

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Purpose of Review Individuals with Down syndrome (DS) may be more susceptible to oral disorders as a result of a combination of genetic factors, immunological disturbances, anatomical anomalies, and probable difficulties in maintaining adequate oral hygiene. Within this context, we provide a comprehensive review of the most important relationships between oral health and Down syndrome. Recent Findings Recent investigations suggest that a diminished diversity in the oral microbiome could emerge as a critical factor affecting oral health in individuals with DS. Plausible anatomical and metabolic peculiarities inherent to DS, including alterations in salivary characteristics, the presence of obstructive sleep apnea, elevated end glycation product levels, and hypothyroidism, may exert a significant influence on the composition and dynamics of the oral microbiome. A comprehensive analysis of the evidence implies a reduced occurrence of caries in individuals with DS. Furthermore, a recent meta-analysis indicates that gingivitis (OR 1.93; 95% CI 1.09–3.41) and periodontitis (OR 3.93; 95% CI 1.81–8.53) are more frequent in people with DS and strongly associated. Oral function in DS is also affected resulting in speech, breathing and eating problems. These findings underscore the necessity to implement targeted educational and awareness programs, along with specific intervention protocols, for the younger generations of individuals with DS, their families, and caregivers. Summary Although trisomy 21 itself does not determine a specific cause of oral diseases in DS, common oral health conditions such as gingivitis, periodontitis, and caries remain a matter of concern. The nexus between insufficient plaque control, distinctive oral characteristics, and reluctance to engage in treatment persists as noteworthy determinants. The necessity for oral health professionals to exercise patience and commitment when addressing oral care for individuals with Down syndrome is crucial.

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Section: Oral Function In Down Syndromementioning

confidence: 99%

A Comprehensive Review of the Relationship Between Oral Health and Down Syndrome

Botero,

Rodríguez-Medina,

Amaya-Sanchez

et al. 2024

Curr Oral Health Rep

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“…Lalu pada saat penderita down syndrome tumbuh dewasa, Seizures terjadi pada orang dengan cognitive decline dan cortical atrophy karena mereka kehilangan keahlian fungsional dan penurunan fungsi kognitif (Lott et.al., 2012). Selain gangguan sensori, penderita down syndrome juga mengalami gangguan tidur seperti Apnea, durasi REM yang berkurang, dan asupan tidur yang buruk (Nguyen et al, 2023). Gangguan tidur ini disebabkan karena penderita down syndrome sulit memfokuskan perhatiannya kepada tugas-tugas sehingga membuat mereka kesusahan untuk tidur.…”

Section: Down Syndrome Ditinjau Dari Intelligenceunclassified

Kelainan Down Syndrome Ditinjau dari Aspek Neurobiological dan Intelligence

Nasywa Achmad,

Putri Damayanti Sulistyo,

Ranita Arindra Rosanti

et al. 2023

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Down syndrome is a disorder caused by the presence of trisomy on the 21st chromosome. People with this disorder show differences in physical characteristics, general intelligence, and other aspects. Research shows that the risk factors for Down syndrome vary between regions and demographic characteristics. Genetic disorders are one of the causes of intellectual disability, which can also lead to the risk of developing infections, autoimmune disorders, and hematological and oncological abnormalities. This study aims to explore more deeply related to Down syndrome from a neurobiological and intelligence perspective. By writing this research, it is hoped that the general public will be able to understand Down syndrome, starting from the causes and effects. The method used in making this article is a literature review, by searching on Google Scholar with several keywords that match the research objectives. The results of the data collection show that neurobiologically, Down syndrome has many dysfunctions in the organs of the body that impact many aspects, one of which is an abnormality in the aspect of intelligence. AbstrakDown syndrome merupakan kelainan yang disebabkan oleh adanya trisomi pada kromosom ke-21. Penderita kelainan ini menunjukkan perbedaan ciri fisik, kecerdasan secara umum, dan aspek-aspek lainnya. Penelitian menunjukkan bahwa faktor risiko dari kelainan down syndrome ini beragam antarwilayah dan karakterisitik demografis. Kelainan genetik menjadi salah satu penyebab dari adanya disabilitas intelektual, yang juga dapat berisiko akan perkembangan infeksi, gangguan autoimun, dan abnormalitas hematologi serta onkologi. Penelitian ini bertujuan untuk mengeksplorasi lebih dalam terkait down syndrome jika ditinjau dari aspek neurobiologis dan intelegensi. Dengan dituliskannya penelitian ini, diharapkan bahwa khalayak umum mampu memahami terkait down syndrome mulai dari penyebab dan akibat. Metode yang digunakan dalam pembuatan artikel ini ialah literature review, melalui pencarian pada Google Scholar dengan beberapa kata kunci yang sesuai dengan tujuan penelitian. Hasil dari pengumpulan data menunjukkan bahwasanya secara neurobiologis, down syndrome memiliki banyak disfungsi pada organ-organ tubuh yang berdampak pada banyak aspek, salah satunya kelainan pada aspek inteligensi.

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‘Personalized medicine’: phenotyping pediatric obstructive sleep apnea

Duong-Quy,

Nguyen-Ngoc-Quynh,

Nguyen-Huu

2024

Current Opinion in Pulmonary Medicine

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Purpose of review Obstructive sleep apnea (OSA) is common in children. Phenotyping pediatric OSA has a crucial role in personalized diagnosis and treatment to improve outcomes for this population. This review sets forth a clinical approach that allows for phenotyping pediatric OSA. Recent findings The emerging concept of phenotyping pediatric OSA is based on identifying a primary cause, which leads to a more precise understanding of the pathogenesis in any individual patient. Phenotyping enables treatment focusing on the primary cause, but does not exclude the need for supplemental management strategies based on other recognizable traits. The identification of pediatric OSA phenotypes (POP) relies on observable characteristics with significant prevalence. This review will concentrate on the most important phenotypes seen in clinical practice: pediatric OSA with craniofacial abnormalities (POPCA); OSA with upper airway disease (POPUAD); OSA with obesity (POPO), and OSA associated with neuromuscular disease (POPNED). Summary Phenotyping pediatric OSA is a form of personalized medicine. By identifying clinical subtypes, individualized treatment plans can be devised in order to choose therapies that are associated with predictable responses. Moreover, it is rare that a therapeutic modality is devoid of possible complications; knowledge of the phenotype being treated can enable early intervention should those occur. Finally, all of the aforementioned phenotypes require personalized support incorporating individualized care plans so as to optimize the quality of life and overall sleep health of children with OSA.

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Sleep apnea in people with Down syndrome: Causes and effects of physical activity?

Cited by 3 publications

References 77 publications

A Comprehensive Review of the Relationship Between Oral Health and Down Syndrome

A Comprehensive Review of the Relationship Between Oral Health and Down Syndrome

Kelainan Down Syndrome Ditinjau dari Aspek Neurobiological dan Intelligence

‘Personalized medicine’: phenotyping pediatric obstructive sleep apnea

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