Sleep apnea is associated with the increase of certain genera of Ruminococcaceae and Lachnospiraceae in the gut microbiome of hypertensive patients

Zhang, Cheng; Chen, Fengwei; Shen, Yane; Chen, Yuqing; Ma, Jing

doi:10.1080/17476348.2022.2147509

Cited by 19 publications

(12 citation statements)

References 46 publications

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“…It has been previously reported that the stability of αdiversity indicates a healthy status of the intestinal microbiome, and both suppressed and increased αdiversity represents a signature of gut microbial disorders, which is frequently associated with diseases, including Pon1-related diseases. [30][31][32] Studies have concluded that the diversity of fecal bacteria is reduced or significantly altered when the host experiences pathological conditions. 30 Dramatically decreased αdiversity parameters of intestinal flora diversity were detected in various diseases, including hypertension, 33 coronary atherosclerosis, 34 and Parkinson's disease.…”

Section: Discussionmentioning

confidence: 99%

“…The diversity of gut bacteria has been widely considered a crucial characteristic linked to health status and multiple diseases. It has been previously reported that the stability of α‐diversity indicates a healthy status of the intestinal microbiome, and both suppressed and increased α‐diversity represents a signature of gut microbial disorders, which is frequently associated with diseases, including Pon1 ‐related diseases 30–32 . Studies have concluded that the diversity of fecal bacteria is reduced or significantly altered when the host experiences pathological conditions 30 .…”

Section: Discussionmentioning

confidence: 99%

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Alteration of the intestinal microbiota and serum metabolites in a mouse model of Pon1 gene ablation

Li,

Yan,

Wang

et al. 2024

The FASEB Journal

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Mutations in the Paraoxonase 1 (Pon1) gene underlie aging, cardiovascular disease, and impairments of the nervous and gastrointestinal systems and are linked to the intestinal microbiome. The potential role of Pon1 in modulating the intestinal microbiota and serum metabolites is poorly understood. The present study demonstrated that mice with genomic excision of Pon1 by a multiplexed guide RNA CRISPR/Cas9 approach exhibited disrupted gut microbiota, such as significantly depressed alpha‐diversity and distinctly separated beta diversity, accompanied by varied profiles of circulating metabolites. Furthermore, genomic knock in of Pon1 exerted a distinct effect on the intestinal microbiome and serum metabolome, including dramatically enriched Aerococcus, linoleic acid and depleted Bacillus, indolelactic acid. Specifically, a strong correlation was established between bacterial alterations and metabolites in Pon1 knockout mice. In addition, we identified metabolites related to gut bacteria in response to Pon1 knock in. Thus, the deletion of Pon1 affects the gut microbiome and functionally modifies serum metabolism, which can lead to dysbiosis, metabolic dysfunction, and infection risk. Together, these findings put forth a role for Pon1 in microbial alterations that contribute to metabolism variations. The function of Pon1 in diseases might at least partially depend on the microbiome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Alteration of the intestinal microbiota and serum metabolites in a mouse model of Pon1 gene ablation

Li,

Yan,

Wang

et al. 2024

The FASEB Journal

View full text Add to dashboard Cite

show abstract

“…Ruminococcaceae is a core bacteria family that exists in the human intestine, and its relative abundance tends to decrease with aging [ 42 ]. Zhang et al [ 43 ] reported an increase in the abundance of Ruminococcaceae in hypertensive patients with sleep apnea compared to those without sleep apnea. In contrast, Jiang et al [ 44 ] reported lower levels of Ruminococcaceae UCG-002 and Ruminococcaceae UCG-003 in the chronic insomnia group compared to the healthy group, which is inconsistent with our finding.…”

Section: Discussionmentioning

confidence: 99%

The relationship between sleep, gut microbiota, and metabolome in patients with depression and anxiety: A secondary analysis of the observational study

Tanaka,

Sanada,

Miyaho

et al. 2023

PLoS ONE

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Background Growing attention is paid to the association between alterations in the gut microbiota and their metabolites in patients with psychiatric disorders. Our study aimed to determine how gut microbiota and metabolomes are related to the sleep quality among patients with depression and anxiety disorders by analyzing the datasets of our previous study. Methods Samples were collected from 40 patients (depression: 32 patients [80.0%]); anxiety disorders: 8 patients [20.0%]) in this study. Gut microbiomes were analyzed using 16S rRNA gene sequencing and gut metabolomes were analyzed by a mass spectrometry approach. Based on the Pittsburgh Sleep Quality Index (PSQI), patients were categorized into two groups: the insomnia group (PSQI score ≥ 9, n = 20) and the non-insomnia group (PSQI score < 9, n = 20). Results The insomnia group showed a lower alpha diversity in the Chao1 and Shannon indices than the non-insomnia group after the false discovery rate (FDR) correction. The relative abundance of genus Bacteroides showed a positive correlation with PSQI scores in the non-insomnia group. The concentrations of glucosamine and N-methylglutamate were significantly higher in the insomnia group than in the non-insomnia group. Conclusions Our findings suggest that specific taxa could affect the sleep quality among patients with depression and anxiety disorders. Further studies are needed to elucidate the impact of sleep on specific gut microbiota and metabolomes in depression and anxiety disorders.

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“…A small study found a higher F/B ratio in individuals with OSA compared to those without OSA, irrespective of comorbid hypertension [ 59 ]. Nevertheless, patients with both OSA and hypertension had lower Ruminococcaceae and Lachnospiraceae than those with OSA only, suggesting that both disorders may exert synergistic, deteriorating effects on the intestinal microbiota.…”

Section: Altered Gut Microbiome In Osa: Implications For Hypertension...mentioning

confidence: 99%

“…Notably, these data may be at variance with those from human studies, showing, for the most part, decreased diversity and an increased F/B ratio in OSA. While the reasons underlying such discrepancy are not completely understood, it can be speculated that the observed changes in microbiome richness due to chronic IH may be an adaptive response [ 59 ]. Metabolomic profiling shows differences in numerous compounds, particularly decreased metabolism of fatty acids and bile acids in mice undergoing IH [ 66 , 67 ].…”

Section: Altered Gut Microbiome In Osa: Implications For Hypertension...mentioning

confidence: 99%

Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary Review

et al. 2023

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Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder and an established risk factor for cardiovascular diseases, including hypertension. The pathogenesis of elevated blood pressure (BP) in OSA is multifactorial, including sympathetic overdrive, vascular aberrations, oxidative stress, inflammation, and metabolic dysregulation. Among the mechanisms potentially involved in OSA-induced hypertension, the role of the gut microbiome is gaining increasing attention. Perturbations in the diversity, composition, and function of the gut microbiota have been causally linked to numerous disorders, and robust evidence has identified gut dysbiosis as a determinant of BP elevation in various populations. In this brief review, we summarize the current body of literature on the implications of altered gut microbiota for hypertension risk in OSA. Data from both preclinical models of OSA and patient populations are presented, and potential mechanistic pathways are highlighted, along with therapeutic considerations. Available evidence suggests that gut dysbiosis may promote the development of hypertension in OSA and may thus be a target for interventions aimed at attenuating the adverse consequences of OSA in relation to cardiovascular risk.

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Sleep apnea is associated with the increase of certain genera of Ruminococcaceae and Lachnospiraceae in the gut microbiome of hypertensive patients

Cited by 19 publications

References 46 publications

Alteration of the intestinal microbiota and serum metabolites in a mouse model of Pon1 gene ablation

Alteration of the intestinal microbiota and serum metabolites in a mouse model of Pon1 gene ablation

The relationship between sleep, gut microbiota, and metabolome in patients with depression and anxiety: A secondary analysis of the observational study

Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary Review

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