Sleep apnea is associated with an increased risk of mood disorders: a population-based cohort study

Lu, Ming-Kun; Tan, Hung-Pin; Tsai, I-Ning; Huang, Li-Chung; Liao, Xin-Ming; Lin, Sheng‐Hsiang

doi:10.1007/s11325-016-1389-x

Cited by 20 publications

(15 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…https://doi.org/10.1183/13993003.02484-2017 SDB are at higher risk of depressive disorders [1,[42][43][44] and have a greater prevalence of other psychiatric comorbidities [45][46][47]. However, the mechanisms underlying the possible association between REM-SDB and depression are not clear.…”

Section: Rem-sdb and Depressionmentioning

confidence: 99%

REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort

et al. 2018

View full text Add to dashboard Cite

This study determined the prevalence of rapid eye movement (REM) related sleep-disordered breathing (REM-SDB) in the general population and investigated the associations of REM-SDB with hypertension, metabolic syndrome, diabetes and depression.Home polysomnography (PSG) recordings (n=2074) from the population-based HypnoLaus Sleep Cohort (48.3% men, 57±11 years old) were analysed. The apnoea-hypopnoea index was measured during REM and non-REM sleep (as REM-AHI and NREM-AHI, respectively). Regression models were used to explore the associations between REM-SDB and hypertension, diabetes, metabolic syndrome and depression in the entire cohort and in subgroups with NREM-AHI <10 events·h and total AHI <10 events·hThe prevalence of REM-AHI ≥20 events·h was 40.8% in the entire cohort. An association between increasing REM-AHI and metabolic syndrome was found in the entire cohort and in both the NREM-AHI and AHI subgroups (p-trend=0.014, <0.0001 and 0.015, respectively). An association was also found between REM-AHI ≥20 events·h and diabetes in both the NREM-AHI <10 events·h (odds ratio (OR) 3.12 (95% CI 1.35-7.20)) and AHI <10 events·h (OR 2.92 (95% CI 1.12-7.63)) subgroups. Systolic and diastolic blood pressure were positively associated with REM-AHI ≥20 events·hREM-SDB is highly prevalent in our middle-to-older age sample and is independently associated with metabolic syndrome and diabetes. These findings suggest that an increase in REM-AHI could be clinically relevant.

show abstract

Section: Rem-sdb and Depressionmentioning

confidence: 99%

REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort

et al. 2018

View full text Add to dashboard Cite

show abstract

“…We did not find a significant association between depression and REM-SDB besides a trend in the NREM-AHI <10 events·h −1 subgroup. Our group and others have previously shown that patients with SDB are at higher risk of depressive disorders [1,[42][43][44] and have a greater prevalence of other psychiatric comorbidities [45][46][47]. However, the mechanisms underlying the possible association between REM-SDB and depression are not clear.…”

Section: Rem-sdb and Depressionmentioning

confidence: 84%

Obstructive sleep apnoea as a risk factor for incident metabolic syndrome: a joined Episono and HypnoLaus prospective cohorts study

et al. 2018

View full text Add to dashboard Cite

@ERSpublications REM sleep-disordered breathing is highly prevalent and is associated with metabolic syndrome and diabetes ABSTRACT This study determined the prevalence of rapid eye movement (REM) related sleepdisordered breathing (REM-SDB) in the general population and investigated the associations of REM-SDB with hypertension, metabolic syndrome, diabetes and depression.Home polysomnography (PSG) recordings (n=2074) from the population-based HypnoLaus Sleep Cohort (48.3% men, 57±11 years old) were analysed. The apnoea-hypopnoea index was measured during REM and non-REM sleep (as REM-AHI and NREM-AHI, respectively). Regression models were used to explore the associations between REM-SDB and hypertension, diabetes, metabolic syndrome and depression in the entire cohort and in subgroups with NREM-AHI <10 events·h −1 and total AHI <10 events·h −1 .The prevalence of REM-AHI ⩾20 events·h −1 was 40.8% in the entire cohort. An association between increasing REM-AHI and metabolic syndrome was found in the entire cohort and in both the NREM-AHI and AHI subgroups ( p-trend=0.014, <0.0001 and 0.015, respectively). An association was also found between REM-AHI ⩾20 events·h −1 and diabetes in both the NREM-AHI <10 events·h −1 (odds ratio (OR) 3.12 (95% CI 1.35-7.20)) and AHI <10 events·h −1 (OR 2.92 (95% CI 1.12-7.63)) subgroups. Systolic and diastolic blood pressure were positively associated with REM-AHI ⩾20 events·h −1 .REM-SDB is highly prevalent in our middle-to-older age sample and is independently associated with metabolic syndrome and diabetes. These findings suggest that an increase in REM-AHI could be clinically relevant.This article has supplementary material available from Outcome variables Body weight and height were measured with participants standing without shoes in light indoor clothes. Body weight was measured in kilograms to the nearest 100 g using a Seca scale (Seca, Hamburg, Germany), which was calibrated regularly. Height was measured to the nearest 5 mm using a Seca height gauge. Body mass index (BMI) was calculated as weight (kg)/height (m 2 ).Waist was measured with a non-stretchable tape over the unclothed abdomen at the narrowest point between the lowest rib and the iliac crest, while hip was measured at the largest part of the hips. Two measures were made for waist and hip and the mean (expressed in centimetres) was used to assess the waist-to-hip ratio (WHR). Neck circumference was measured at the middle of the neck between the mid-cervical spine and the superior line of the cricothyroid membrane.

show abstract

“…son estas obstrucciones repetitivas las que desencadenan los mecanismos fisiopatológi-cos que tendrán repercusión patológica a corto, mediano y largo plazo, a saber: 1) Cambios en la presión negativa intratorácica; 2) Hipoxia intermitente crónica; 3) Fragmentación del sueño y 4) Privación parcial del sueño 1 . entre las consecuencias de la aos destacan su asociación conocida con: aumento de la morbilidad y mortalidad cardiovascular 2,3 , aumento de trastornos depresivos [4][5][6][7] , aumento del riesgo de accidentes de tráfico [8][9][10] , pérdida de productividad (incluyendo ausentismo laboral) 11-13 y deterioro neurocognitivo 14,15 y de la calidad de vida [16][17][18] . todo lo anterior implica un alto costo sanitario, especialmente en relación con los pacientes no tratados 16,19 .…”

unclassified

“…debido al alto costo y la escasa cobertura de la polisomnografía (Psg) -que es el Gold Estándar para el diagnóstico-se han desarrollado dispositivos para diagnóstico ambulatorio y diversos cuestionarios de sueño y reglas de predicción clínica (rPC), con el propósito de contar con herramientas que permitan el tamizaje en población general y en poblaciones con comorbilidades asociadas. uno de estos, el Cuestionario stoP-Bang (CsB), originalmente desarrollado como herramienta para detectar aos en pacientes obesos 45,8% (41,9), Medio 41,1% (37,1), Alto 13,[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]5). Riesgo en mujeres: Bajo 74,6% (71,4), Medio 21,8% (19,4), Alto 3,6% (2,1 candidatos a cirugía bariátrica 34 , posteriormente ha sido aplicado a otras poblaciones quirúrgicas y de pacientes derivados a clínicas de sueño 35 .…”

unclassified

“…uno de estos, el Cuestionario stoP-Bang (CsB), originalmente desarrollado como herramienta para detectar aos en pacientes obesos 45,8% (41,9), Medio 41,1% (37,1), Alto 13,[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]5). Riesgo en mujeres: Bajo 74,6% (71,4), Medio 21,8% (19,4), Alto 3,6% (2,1 candidatos a cirugía bariátrica 34 , posteriormente ha sido aplicado a otras poblaciones quirúrgicas y de pacientes derivados a clínicas de sueño 35 . es una herramienta de tamizaje replicable, concisa y fácil de usar.…”

unclassified

See 1 more Smart Citation

Prevalencia de riesgo de apnea obstructiva del sueño en población adulta chilena

Carrillo

Vargas

Cisternas

et al. 2017

Rev. chil. enferm. respir.

View full text Add to dashboard Cite

show abstract

Sleep apnea is associated with an increased risk of mood disorders: a population-based cohort study

Abstract: There is a greater likelihood of MD manifesting in patients with a history of sleep apnea. Health professionals are thus advised to carefully monitor the psychological impacts of sleep apnea.

Cited by 20 publications

References 39 publications

REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort

REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort

Obstructive sleep apnoea as a risk factor for incident metabolic syndrome: a joined Episono and HypnoLaus prospective cohorts study

Prevalencia de riesgo de apnea obstructiva del sueño en población adulta chilena

Contact Info

Product

Resources

About