Sleep Apnea Syndrome (SAS) Clinical Practice Guidelines 2020

Akashiba, Tsuneto; Inoue, Yuichi; Uchimura, Naohisa; Ohi, Motoharu; Kasai, Takatoshi; Kawana, Fusae; Sakurai, Shigeru; Takegami, Misa; Tachikawa, Rho; Tanigawa, Takeshi; Chiba, Shintaro; Chin, Kazuo; Tsuiki, Satoru; Tonogi, Morio; Nakamura, Hiroshi; Nakayama, Takeo; Narui, Koji; Yagi, Tomoko; Yamauchi, Motoo; Yamashiro, Yuichiro; Yoshida, Masahiro; Oga, Toru; Tomita, Yasuhiro; Hamada, Shin; Murase, Kimihiko; Mori, Hiroyuki; Wada, Hiroo; Uchiyama, Makoto; Ogawa, Hiroyasu; Sato, Kazumichi; Nakata, Seiichi; Mishima, Kazuo; Momomura, Shin‐ichi

doi:10.1016/j.resinv.2021.08.010

Cited by 36 publications

(19 citation statements)

References 205 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diabetes was diagnosed according to the diagnostic criteria of the Japan Diabetes Society [ 20 ]; hypertension according to the Japanese Society of Hypertension [ 21 ]; dyslipidemia according to the Japan Atherosclerosis Society [ 22 ]; and OSAS according to the Japanese Respiratory Society [ 20 ]. The ABCD score has been reported as a score that predicts improvement in T2DM, and is appropriate for the Japanese population [ 21 , 22 , 23 ].…”

Section: Methodsmentioning

confidence: 99%

Factors Associated with Relapse of Type 2 Diabetes Mellitus after Laparoscopic Sleeve Gastrectomy in Japanese Subjects: A Subgroup Analysis of J-SMART Study

et al. 2023

View full text Add to dashboard Cite

Introduction: Laparoscopic sleeve gastrectomy (LSG) for morbidly obese patients often result in remission of type 2 diabetes (T2DM), but diabetes relapses in some of those patients. The frequency of T2DM relapse in Asians and the factors involved have not been adequately investigated. Methods: The J-SMART study was conducted on 322 Japanese subjects with body mass index (BMI) ≥ 32 kg/m2 who underwent LSG at 10 accredited centers in Japan between 2011 and 2014. Of these, 82 T2DM subjects with diabetes in complete or partial remission at 1 year after LSG and followed postoperatively for 5 years were included in the subgroup analysis, and classified into two groups: diabetes remission maintained and diabetes relapse. Results: The mean age of all included subjects was 49.2 years, median BMI was 41.5 kg/m2, and median was HbA1c 6.7%. Compared with the diabetes remission maintained group, the diabetes relapse group at 5 years after LSG had significantly higher preoperative HbA1c, number of antidiabetic medications, and high-density lipoprotein cholesterol level; and lower BMI and homeostasis model assessment-beta cell function (HOMA-β). As many as 83.0% of the subjects were able to achieve HbA1c < 7% at 5 years after LSG, but 26.8% of the subjects had diabetes relapse. Preoperative HbA1c significantly contributed to diabetes relapse (odds ratio 1.54, p = 0.049). In addition, the diabetes relapse group tended to have lower percent total weight loss (%TWL) at 1 year after LSG and higher percent weight regain (%WR) from postoperative nadir weight, compared with the diabetes remission maintained group. The hazard ratio for diabetes relapse was 3.14-fold higher in subjects with %TWL ≥ 20% and %WR ≥ 25%, and 5.46-fold higher in those with %TWL < 20% and %WR ≥ 25%, compared with %TWL ≥ 20% and %WR < 25%. Conclusion: While LSG provides a high remission rate for T2DM, relapse is not uncommon. Preoperative HbA1c, poor weight loss and excess weight regain after LSG contribute to diabetes relapse, suggesting the importance of treatment strategies focusing on these factors.

show abstract

Section: Methodsmentioning

confidence: 99%

Factors Associated with Relapse of Type 2 Diabetes Mellitus after Laparoscopic Sleeve Gastrectomy in Japanese Subjects: A Subgroup Analysis of J-SMART Study

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Zespół obturacyjnych bezdechów podczas snu (OBPS) jest spotykany u coraz większej liczby pacjentów -według aktualnych badań zespołu OBPS o umiarkowanym i ciężkim przebiegu doświadcza do 20% mężczyzn oraz do 10% kobiet po menopauzie [1]. Jego wpływ na rozwój chorób układu sercowo-naczyniowego oraz nieprzestrzeganie przez pacjentów zaleceń leczniczych zmuszają do badań nad nowoczesnymi rodzajami terapii, także tej farmakologicznej.…”

Section: Wprowadzenieunclassified

Cannabinoids in treatment of obstructive sleep apnea syndrome

Szot¹,

Krzeski²

2022

Med Og Nauk Zdr.

View full text Add to dashboard Cite

Wprowadzenie i cel pracy. Zespół obturacyjnych bezdechów podczas snu (OBPS) jest spotykany u coraz większej liczby pacjentów. Jego negatywny wpływ na układ sercowo--naczyniowy oraz nieprzestrzeganie przez pacjentów zaleceń leczniczych zmuszają do badań nad nowoczesnymi rodzajami terapii, także tej farmakologicznej. Celem niniejszego przeglądu piśmiennictwa jest przedstawienie możliwości stosowania substancji z grupy kannabinoidów -kannabidiolu (CBD), delta 9-tetrahydrokannabinolu (THC) oraz ich syntetycznych analogów w leczeniu zespołu OBPS. Metody przeglądu. Użycie elektronicznej bazy danych Pubmed oraz rejestrów badań klinicznych pozwoliło znaleźć przeglądy piśmiennictwa, badania przedkliniczne oraz kliniczne dotyczące farmakoterapii zespołu OBPS substancjami z grupy kannabinoidów. Użyto słów kluczowych "OSAS pharmacotherapy", "cannabinoid", "sleep apnea" oraz ich kombinacji. Wybrane prace oryginalne zostały opublikowane w latach 2010-2021 oraz dotyczyły wpływu syntetycznego odpowiednika THC, dronabinolu, na ilościowe i jakościowe parametry snu. Opis stanu wiedzy. Badania nad kannabinoidami w leczeniu zespołu OBPS, mimo małej ilości danych, dają obiecujące wyniki, które wykazują ich skuteczność. Syntetyczny analog THC, dronabinol, jest lekiem zmniejszającym liczbę bezdechów podczas snu, poprawiającym jego jakość oraz zwiększającym udział snu wolnofalowego. Podczas badań został uznany za lek bezpieczny i dobrze tolerowany. Podsumowanie. Mimo iż aktualne wyniki badań dowodzą skuteczności leków z grupy kannabinoidów w leczeniu zespołu OBPS, konieczne jest przeprowadzenie badań wieloośrodkowych, aby określić ich profil bezpieczeństwa, długoterminowe skutki ich stosowania, odpowiednie dawkowanie oraz ustalić, pacjenci o którym fenotypie mogą zyskać najwięcej ze stosowania takiej terapii.

show abstract

“…Furthermore, OSA is directly associated with hypertension, cardiovascular disease, and cerebrovascular disease [1,2], and increases mortality [3][4][5]. Continuous positive airway pressure (CPAP) is the first-choice treatment for OSA and is recommended for patients with severe forms of the disease [6,7]. Although CPAP improves cardiovascular parameters of OSA [8], its effectiveness in improving prognosis cannot be noted unless CPAP is used as prescribed [9,10].…”

Section: Introductionmentioning

confidence: 99%

The relationship between adherence to continuous positive airway pressure and nasal resistance measured by rhinomanometry in patients with obstructive sleep apnea syndrome

Fujito

Ohshima²,

Hokari³

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Nasal breathing disorders are associated with obstructive sleep apnea (OSA) syndrome and influence the availability of continuous positive airway pressure (CPAP) therapy. However, information is scarce about the impact of nasal resistance assessed by rhinomanometry on CPAP therapy. This study aimed to examine the relationship between CPAP adherence and nasal resistance evaluated by rhinomanometry, and to identify clinical findings that can affect adherence to CPAP therapy for patients with OSA. This study included 260 patients (199 men, 61 women; age 58 [interquartile ranges (IQR) 50–66] years) with a new diagnosis of OSA who underwent rhinomanometry (before, and 1 and 3 months after CPAP introduction) between January 2011 and December 2018. CPAP use was recorded, and the good and poor CPAP adherence groups at the time of patient registration were compared. Furthermore, those with improved and unimproved pre-CPAP high rhinomanometry values were also compared. Their apnea-hypopnea index (AHI) by polysomnography at diagnosis was 45.6 (IQR 33.7–61.6)/hour, but the residual respiratory event (estimated AHI) at enrollment was 2.5 (IQR 1.4–3.9)/hour and the usage time was 318 (IQR 226–397) minutes, indicating that CPAP was effective and adherence was good. CPAP adherence was negatively correlated with nasal resistance (r = -0.188, p = 0.002). The participants were divided into good (n = 153) and poor (n = 107) CPAP adherence groups. In the poor adherence group, rhinomanometry values before CPAP introduction were worse (inspiration, p = 0.003; expiration, p = 0.006). There was no significant difference in patient background when comparing those with improved (n = 16) and unimproved (n = 12) pre-CPAP high rhinomanometry values. However, CPAP usage time was significantly longer in the improved group 1 month (p = 0.002) and 3 months (p = 0.026) after CPAP introduction. The results suggest that nasal resistance evaluated by rhinomanometry is a useful predictor of CPAP adherence, and that improved rhinomanometry values may contribute to extending the duration of CPAP use.

show abstract

Sleep Apnea Syndrome (SAS) Clinical Practice Guidelines 2020

Cited by 36 publications

References 205 publications

Factors Associated with Relapse of Type 2 Diabetes Mellitus after Laparoscopic Sleeve Gastrectomy in Japanese Subjects: A Subgroup Analysis of J-SMART Study

Factors Associated with Relapse of Type 2 Diabetes Mellitus after Laparoscopic Sleeve Gastrectomy in Japanese Subjects: A Subgroup Analysis of J-SMART Study

Cannabinoids in treatment of obstructive sleep apnea syndrome

The relationship between adherence to continuous positive airway pressure and nasal resistance measured by rhinomanometry in patients with obstructive sleep apnea syndrome

Contact Info

Product

Resources

About