Sleep Apnoea and Cancer: Is There a Relationship?

Abstract

In recent decades, obstructive sleep apnoea (OSA) has come to represent a major public health problem due to its prevalence and its health consequences. Although the association between OSA and cardiovascular morbidity and mortality is well recognized, its role as a promoter for the development and extension of neoplasms is less known. In recent years, intensive research on the subject has been developed. Bench and animal studies demonstrate how sleep fragmentation and intermittent hypoxia, characteristic phenomena of OSA, are capable of inducing tumorigenesis in various organs and cell lines. However, clinical and population-based epidemiological studies are showing certain contradictory results. These topics are reviewed and discussed in this paper.

Historical biogeography of Cannabis in the Iberian Peninsula: palynological evidence

“…The Late Antiquity and the Middle Ages (5 th -15 th centuries CE) signified the progressive southward expansion of Christian cultures and the unification of monarchies, followed by the consolidation of the modern geographical and political configuration. After the Middle Ages, the kingdoms of the IP shifted from colonized to colonizer countries and expanded their dominions all over the world, with emphasis on the American continent, a situation that remained until the 19 th -20 th centuries CE (Marín, 1995).…”