Sleep apnoea and nocturnal angina

Franklin, Karl A.; Sahlin, Carin; Nilsson, Johan; Näslund, Ulf

doi:10.1016/s0140-6736(95)90820-x

Cited by 238 publications

(135 citation statements)

References 6 publications

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“…Nocturnal angina and ST depression are diminished during treatment of sleep apnea by CPAP. 186,265 Similarly, Hanly et al 266 noted the ST depression occurred in about a third of patients with severe OSA. ST depression was markedly attenuated during nasal CPAP.…”

Section: Prevalence Of Sleep Apnea In Coronary Artery Diseasementioning

confidence: 95%

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Sleep Apnea and Cardiovascular Disease

et al. 2008

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Section: Prevalence Of Sleep Apnea In Coronary Artery Diseasementioning

confidence: 95%

“…Consequent metabolic mismatch could directly reduce myocardial contractility. 185 These stresses may place the patient with OSA and heart failure at greater risk of myocardial ischemia, 186 worsening ventricular function, arrhythmias, and death.…”

Section: Osa and The Origin And Progression Of Heart Failurementioning

confidence: 99%

Sleep Apnea and Cardiovascular Disease

et al. 2008

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“…OSA is associated with coronary risk factors 26,27,28,29,30,31 and with known symptomatic coronary artery disease identified by angiography 32 . OSA was present in 9 of 10 patients with nocturnal angina pectoris 33 and in 37% of men and 30% of women with coronary artery disease 34 . After the first acute myocardial infarction, 65.7% of patients had an apnea-hypopnea index ≥ 15/h 35 .…”

Section: Discussionmentioning

confidence: 98%

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

et al. 2012

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Obstructive sleep apnea (OSA), a risk factor for coronary artery disease, remains under diagnosed. We investigated if OSA identified by the Berlin Questionnaire (BQ) is associated with the risk of coronary artery disease. Cases were patients referred for elective coronariography. The cases were classified with significant coronary lesions (stenosis > 50% in an epicardial coronary) or without significant coronary lesions. Controls were selected from a population-based sample. Positive BQ results were identified in 135 (41.2%) of 328 cases, in contrast with 151 (34.4%) of 439 control subjects (p = 0.03). In a multinomial logistic analysis, the risk for OSA identified by the BQ was independently associated with coronary artery disease in cases with lesions of at least 50% (OR = 1.53; 95%CI: 1.02-2.30; p = 0.04). The risk from OSA identified by the BQ was higher in younger subjects (40-59 years) (OR = 1.76; 95%CI: 1.05-2.97; p = 0.03) and in women (OR = 3.56; 95%CI: 1.64-7.72; p = 0.001). In conclusion, OSA identified by the BQ greatly increases the risks of coronary artery disease in patients having significant coronary artery lesions indicated by anangiogram, particularly in younger individuals and in women.

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“…1 About 20% of subjects with OSA report daytime sleepiness and thereby fulfil the treatment criterion for obstructive sleep apnoea syndrome (OSAS). The importance of investigating the association between sleep related breathing disorders and cardiovascular disease is stressed by reports of a high prevalence of sleep apnoea among patients with hypertension (HT) [2][3][4] and coronary artery disease, 5 as well as an increased mortality in patients with sleep apnoea. 6 Whether this is a true causal relationship or whether it is partly or completely caused by confounding is still a matter of debate.…”

mentioning

confidence: 99%

Prevalence of sleep apnoea and snoring in hypertensive men: a population based study

Sjöström

Lindberg²,

Elmasry³

et al. 2002

Thorax

120

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Background: Several studies have reported an association between sleep disordered breathing (SDB) and hypertension (HT) but there is still a debate as to whether this is an effect of confounders. Some researchers have found an age dependent relationship between SDB and HT with higher risk at lower ages. A case-control study was performed in hypertensive men and non-hypertensive male controls matched for age and body mass index to assess whether there is an independent association between SDB and HT. If so, we further wanted to investigate whether this effect is age dependent. Methods: An overnight sleep study was performed in a population based, age stratified sample of 102 hypertensive men aged 43-82 years and 102 non-hypertensive controls. Results: Hypertensive subjects had a significantly higher prevalence of SDB than non-hypertensive subjects (apnoea-hypopnoea index (AHI): 10.8 v 7.3; desaturation index (DI): 8.5 v 5.2; AHI >10: 37% v 24%, p<0.05; DI >10: 29% v 12%; lowest desaturation: mean (SD) 81.9 (7.3) v 84.7 (6.1), p<0.01). After adjusting for neck circumference and physical inactivity, DI >10 and lowest desaturation were still independent predictors of HT with adjusted odds ratios of 2.3 (95% CI 1.0 to 5.3) and 0.94 (95% CI 0.89 to 0.99), respectively. When the subjects were split into two groups according to age (<60 and >60 years), the influence of DI >10 on HT was strongest in the younger men (adjusted OR 4.3 (95% CI 1.0 to 19.3 v 2.1 (95% CI 0.7 to 6.5)) and the association between minimum oxygen saturation (SaO 2 ) and HT reached statistical significance in the younger men only. Conclusion: SDB is more prevalent in men with HT than in controls. DI >10 and lowest desaturation are independent predictors of HT irrespective of confounders. The results indicate that the influence of SDB on HT is more pronounced in younger and middle aged men than in those above 60 years.

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Sleep apnoea and nocturnal angina

Cited by 238 publications

References 6 publications

Sleep Apnea and Cardiovascular Disease

Sleep Apnea and Cardiovascular Disease

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

Prevalence of sleep apnoea and snoring in hypertensive men: a population based study

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