Sleep body position correlates with cognitive performance in middle-old obstructive sleep apnea subjects

Girolami, Sara; Tardio, Marta; Loredana, Serpetti; Mattia, Nadia Di; Micheletti, Pamela; Napoli, Mario Di

doi:10.1016/j.sleepx.2022.100050

Cited by 1 publication

(1 citation statement)

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“…43 However, previous studies have not shown a consistent pattern of brain damage, possibly because of participant selection, such as age, 44 and condition severity. 45 The main component of the brain WM is the myelin sheath, which is produced by mature oligodendrocytes 46 and is vulnerable to hypoxic factors. DTI allows the quantitative observation of microstructural changes in brain tissue.…”

Section: Discussionmentioning

confidence: 99%

Microstructural Changes in the Cerebral White Matter After 12 Months of CPAP Treatment for Moderate to Severe Obstructive Sleep Apnoea: A TBSS Study

Liu,

Wei,

Ting

et al. 2024

NSS

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Continuous positive airway pressure (CPAP) therapy improves clinical symptoms in patients with obstructive sleep apnea (OSA); however, the mechanism of this clinical improvement and how it may be associated with the restoration of white matter (WM) structures in the brain is unclear. Therefore, this study investigated the relationship between the structural recovery of brain WM and improvements in cognitive function and emotion after long-term (12 months) CPAP treatment in patients with OSA. Methods: We collected data from 17 patients with OSA before and 12 months after CPAP treatment, including sleep monitoring, clinical assessment, and diffusion tensor imaging (DTI) magnetic resonance imaging. Results: We observed a partial reversible recovery of brain WM (mean and radial diffusion coefficients) after treatment. This recovery involved the commissural fibers (cingulum, body of corpus callosum), projection fibers (retrolenticular part of the internal capsule, posterior thalamic radiation, posterior limb of the internal capsule, superior corona radiata, posterior corona radiata), association fibers (external capsule, superior longitudinal fasciculus, inferior longitudinal fasciculus), and other regions. In addition, the improvements in WM fibers in one part of the brain significantly were correlated with the Hamilton Anxiety Scale and Hamilton Depression Scale scores. Discussion: Our results suggest that reversible recovery of reduced brain WM integrity due to OSA may require longer CPAP treatment. Moreover, changes in the integrity of the commissural fibers were associated with emotion regulation. These restored WM areas may explain the cognitive and mood improvements observed after OSA treatment.

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