Sleep characteristics and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact older adults: The CABLE study

Xu, Wei; Tan, Lan; Su, Bing-Jie; Yu, Hui; Bi, Yan‐Lin; Yue, Xiao-Fang; Dong, Qiang; Yu, Jin‐Tai

doi:10.1002/alz.12117

Cited by 60 publications

(54 citation statements)

References 40 publications

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“…In cognitively unimpaired older adults, various sleep parameters have been associated with greater global Aß levels measured in the CSF or using PET, including poorer self-reported sleep quality, both cross-sectionally (Sprecher et al, 2017) and longitudinally (Fjell et al, 2018), longer subjective (Brown et al, 2016) and objective (Ettore et al, 2019) sleep latency, both insufficient and long self-reported sleep duration (Spira et al, 2013;Xu et al, 2020), lower sleep efficiency (Ettore et al, 2019;Ju et al, 2013;Molano et al, 2017), increased sleep fragmentation (Ettore et al, 2019;Lucey et al, 2019;Wilckens et al, 2018), excessive daytime sleepiness (Xu et al, 2020), and altered slow wave activity (SWA) (Ju et al, 2017;Varga et al, 2016;Winer et al, 2019) (Table 1). Furthermore, Mander et al, (2015) showed that amyloid burden in medial prefrontal areas disrupts SWA, negatively affecting sleep-dependent memory consolidation.…”

Section: Sleep and Amyloid Pathologymentioning

confidence: 99%

Brain changes associated with sleep disruption in cognitively unimpaired older adults: A short review of neuroimaging studies

André

Lanièpce

Chételat

et al. 2021

Ageing Research Reviews

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Ageing is characterized by a progressive decline of sleep quality. Sleep difficulties are increasingly recognized as a risk factor for Alzheimer's disease (AD), and have been associated with cognitive decline. However, the brain substrates underlying this association remain unclear. In this review, our objective was to provide a comprehensive overview of the relationships between sleep changes and brain structural, functional and molecular integrity, including amyloid and tau pathologies in cognitively unimpaired older adults. We especially discuss the topography and causality of these associations, as well as the potential underlying mechanisms. Taken together, current findings converge to a link between several sleep parameters, amyloid and tau levels in the CSF, and neurodegeneration in diffuse frontal, temporal and parietal areas. However, the existing literature remains heterogeneous, and the specific sleep changes associated with early AD pathological changes, in terms of topography and neuroimaging modality, is not clearly established yet. Notably, if slow wave sleep disruption seems to be related to frontal amyloid deposition, the brain correlates of sleepdisordered breathing and REM sleep disruption remains unclear. Moreover, sleep parameters associated with tau-and FDG-PET imaging are largely unexplored. Lastly, whether sleep disruption is a cause or a consequence of brain alterations remains an open question.

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Section: Sleep and Amyloid Pathologymentioning

confidence: 99%

Brain changes associated with sleep disruption in cognitively unimpaired older adults: A short review of neuroimaging studies

André

Lanièpce

Chételat

et al. 2021

Ageing Research Reviews

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“…Several mechanisms may explain the impact of sleep duration on cognition. Short sleep duration correlates with many pathologies that lead to lower cognition, such as impaired β-amyloid (Aβ) clearance, pathological tau, impaired synaptic plasticity, atrophy of the cortex, and circadian rhythm disturbances (Yaffe et al, 2014;Malkani and Zee, 2018;Xu et al, 2020). Long sleep duration is also associated with sleep fragmentation and chronic inflammation, which are linked to lower cognition (Lin et al, 2018;Wilcox et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Exploring the Bidirectional Associations Between Short or Long Sleep Duration and Lower Cognitive Function: A 7-Year Cohort Study in China

Hua

Zhuang

Shen

et al. 2021

Front. Aging Neurosci.

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Background: Sleep duration is linked to cognitive function, but whether short or prolonged sleep duration results from impaired cognition or vice versa has been controversial in previous studies. We aimed to investigate the bidirectional association between sleep duration and cognitive function in older Chinese participants.Methods: Data were obtained from a nationally representative study conducted in China. A total of 7984 participants aged 45 years or older were assessed at baseline between June 2011 and March 2012 (Wave 1), 2013 (Wave 2), 2015 (Wave 3), and 2018 (Wave 4). Nocturnal sleep duration was evaluated using interviews. Cognitive function was examined via assessments of global cognition, including episodic memory, visuospatial construction, calculation, orientation and attention capacity. Latent growth models and cross-lagged models were used to assess the bidirectional association between sleep duration and cognitive function.Results: Among the 7,984 participants who were followed in the four waves of the study, the baseline mean (SD) age was 64.7 (8.4) years, 3862 (48.4%) were male, and 6453 (80.7%) lived in rural areas. Latent growth models showed that both sleep duration and global cognition worsened over time. Cross-lagged models indicated that short or long sleep duration in the previous wave was associated with lower global cognition in the subsequent wave (standardized β = −0.066; 95% CI: −0.073, −0.059; P < 0.001; Wave 1 to 2) and that lower global cognition in the previous wave was associated with short or long sleep duration in the subsequent wave (standardized β = −0.106; 95% CI: −0.116, −0.096; P < 0.001; Wave 1 to 2).Conclusion: There was a bidirectional association between sleep duration and cognitive function, with lower cognitive function having a stronger association with long or short sleep duration than the reverse relationship. Global cognition was likely the major driver in these reciprocal associations.

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“…Several mechanisms could explain the impact of sleep duration on cognition. Short sleep duration correlated with many pathologies which would lead to lower cognition, such as impaired β-amyloid (Aβ) clearance, pathologic tau, impaired synaptic plasticity, and circadian rhythm disturbances 33-35 . Long sleep duration was associated with sleep fragmentation and chronic inflammatory, which were associated with lower cognition 36,37 .…”

Section: Discussionmentioning

confidence: 99%

Bidirectional Associations between Short or Long Sleep Duration and Cognitive Function: the China Health and Retirement Longitudinal Study

Hua

Sun

Fang

2021

Preprint

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IMPORTANCEThe bidirectional association between sleep duration and cognitive function has not been conclusively demonstrated.OBJECTIVETo investigate the longitudinal association between sleep duration and cognitive function among middle-aged and elderly Chinese participants.Design, SETTING, AND PARTICIPANTSA national representative and prospective longitudinal study in China. 7984 participants aged 45 years and above were assessed at baseline between June 2011 and March 2012 (wave 1) and 2013 (wave 2), 2015 (wave 3) and 2018 (wave4).MAIN OUCOMES AND MEASURESSelf-reported nighttime sleep duration was evaluated by interview. Cognitive function was evaluated via assessments of global cognition, which reflected the ability of episodic memory, visuospatial construction, calculation, orientation and attention.ResultsRegarding the 7984 participants in wave 4, the mean (SD) age was 64.7 (8.4), 3862 (48.4) were male, and 6453 (80.7) lived in rural area. There were 14981, 11768 (78.6%), 10192 (68.0%), 7984 (53.3%) participants in the four waves of the study, respectively. Latent growth models showed both sleep duration and global cognition worsen over time. Cross-lagged models indicated that long or short sleep duration in the previous wave was associated lower global cognition in the next wave (standardized β=-0.066; 95%CI: −0.073, −0.059; P<0.001; Wave 1 to 2), and lower global cognition in the previous wave was associated with long or short sleep duration in the next wave (standardized β=-0.106; 95%CI: −0.116, −0.096; P<0.001; Wave 1 to 2). Global cognition was probably the major driver in this reciprocal associations.CONCLUSIONS AND REVELANCEThere were bidirectional associations between long or short sleep duration and cognitive function. Lower cognitive function had a stronger association with worse cognitive function than the reverse. A moderate sleep duration is always recommended. Moreover, attention should be paid on the declined cognition and cognitive therapy among older adults with short or long sleep duration.

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Sleep characteristics and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact older adults: The CABLE study

Cited by 60 publications

References 40 publications

Brain changes associated with sleep disruption in cognitively unimpaired older adults: A short review of neuroimaging studies

Brain changes associated with sleep disruption in cognitively unimpaired older adults: A short review of neuroimaging studies

Exploring the Bidirectional Associations Between Short or Long Sleep Duration and Lower Cognitive Function: A 7-Year Cohort Study in China

Bidirectional Associations between Short or Long Sleep Duration and Cognitive Function: the China Health and Retirement Longitudinal Study

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