Sleep Characteristics and Daytime Cortisol Levels in Older Adults

Morgan, Ethan; Schumm, L. Philip; McClintock, Martha K.; Waite, Linda J.; Lauderdale, Diane S.

doi:10.1093/sleep/zsx043

Cited by 26 publications

(19 citation statements)

References 49 publications

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“…The objective sleep parameters from actigraphy of this study were similar to the results from two previous studies that used actigraphy to measure sleep-wake disturbances in older adults (Kurina et al, 2015; Morgan et al, 2017). However, there are some differences between the current study findings and those of past studies in perceived sleep results.…”

Section: Discussionsupporting

confidence: 78%

Sleep-Wake Disturbances and Episodic Memory in Older Adults

Yeh

Pressler

Algase

et al. 2020

Biological Research For Nursing

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Sleep-wake disturbances have been associated with episodic memory loss, but past studies were limited by use of single measures of objective or perceived disturbances. Notably, cognitive reserve and depressive symptoms have been associated with sleep-wake disturbances and poorer episodic memory in older adults. The aims of this study were to determine the relationship between episodic memory and sleep-wake disturbances using objective and perceived measures in older adults and to examine cognitive reserve and depressive symptoms as moderators of this relationship. In this descriptive study, 62 healthy older adults (mean age: 69.9 years; 75.8% women) were recruited from the University of Michigan Clinical Research Program. Objective sleep-wake disturbances were measured by 7-day actigraphy and perceived sleep-wake disturbances by the Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale. Episodic memory was measured by the Hopkins Verbal Learning Test-Revised. Analyses involved Pearson’s correlation coefficients and hierarchical multiple regression. Results showed that more objectively measured sleep disruption was associated with poorer episodic memory and more perceived daytime sleepiness was associated with better episodic memory. Cognitive reserve and depressive symptoms were not moderators of this relationship. In this study, the relationship between sleep-wake disturbances and episodic memory differed by type of measure, objective or perceived. Future studies are needed using multiple measures of episodic memory to further understand the sleep-wake disturbances and episodic memory relationship in a larger diverse sample of healthy older adults.

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Section: Discussionsupporting

confidence: 78%

Sleep-Wake Disturbances and Episodic Memory in Older Adults

Yeh

Pressler

Algase

et al. 2020

Biological Research For Nursing

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“…Total or partial SD has been shown to induce mild stress in rodents ( Coenen and van Luijtelaar, 1985 ; Tobler et al, 1983 ). Additionally, sleep alterations correlate with a rise in cortisol levels in older human subjects ( Castello-Domenech et al, 2016 ; Morgan et al, 2017 ). We collected blood from young (n = 5) and old (n = 5) mice following 5 h of SD (experimental groups) or 5 h of ad libitum sleep (control groups) to determine whether our sleep manipulations had a differential effect on corticosterone levels.…”

Section: Resultsmentioning

confidence: 99%

Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice

et al. 2021

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“…First, an important mechanism underlying neuropsychiatric and cardiovascular conditions is dysregulations in the hypothalamic-pituitary-adrenal (HPA) axis [45,46], which are also implicated in sleep disturbances. Poor sleep quality enhances the reactivity of the HPA axis and is associated with higher daytime cortisol levels [47,48], and altered cortisol awakening response [49]. The relationship between sleep disturbances and HPA axis dysregulations may be bidirectional, as HPA axis hyperactivation is also associated with poor sleep [50].…”

Section: Discussionmentioning

confidence: 99%

Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study

Sindi

Pérez

Vetrano

et al. 2020

BMC Med

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Background Sleep disturbances are prevalent among older adults and are associated with various individual diseases. The aim of this study was to investigate whether sleep disturbances are associated with the speed of multimorbidity development among older adults. Methods Data were gathered from the Swedish National study of Aging and Care in Kungsholmen (SNAC-K), an ongoing population-based study of subjects aged 60+ (N = 3363). The study included a subsample (n = 1189) without multimorbidity at baseline (< 2 chronic diseases). Baseline sleep disturbances were derived from the Comprehensive Psychiatric Rating Scale and categorized as none, mild, and moderate–severe. The number of chronic conditions throughout the 9-year follow-up was obtained from clinical examinations. Linear mixed models were used to study the association between sleep disturbances and the speed of chronic disease accumulation, adjusting for sex, age, education, physical activity, smoking, alcohol consumption, depression, pain, and psychotropic drug use. We repeated the analyses including only cardiovascular, neuropsychiatric, or musculoskeletal diseases as the outcome. Results Moderate–severe sleep disturbances were associated with a higher speed of chronic disease accumulation (ß/year = 0.142, p = 0.008), regardless of potential confounders. Significant positive associations were also found between moderate–severe sleep disturbances and neuropsychiatric (ß/year = 0.041, p = 0.016) and musculoskeletal (ß/year = 0.038, p = 0.025) disease accumulation, but not with cardiovascular diseases. Results remained stable when participants with baseline dementia, cognitive impairment, or depression were excluded. Conclusion The finding that sleep disturbances are associated with faster chronic disease accumulation points towards the importance of early detection and treatment of sleep disturbances as a possible strategy to reduce chronic multimorbidity among older adults.

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Sleep Characteristics and Daytime Cortisol Levels in Older Adults

Abstract: Actigraph measures of sleep disturbance are associated with higher daytime cortisol among older adults. However, cross-sectional data cannot distinguish causal direction or whether cortisol and sleep disruption have a common cause.

Cited by 26 publications

References 49 publications

Sleep-Wake Disturbances and Episodic Memory in Older Adults

Sleep-Wake Disturbances and Episodic Memory in Older Adults

Differential effect of sleep deprivation on place cell representations, sleep architecture, and memory in young and old mice

Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study

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