Sleep Characteristics of Family Caregivers of Individuals With a Primary Malignant Brain Tumor

Pawl, Jean D.; Lee, Shih‐Yu; Clark, Patricia C.; Sherwood, Paula R.

doi:10.1188/13.onf.171-179

Cited by 43 publications

(61 citation statements)

References 58 publications

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“…Through systematic assessments of caregiver sleep and anxiety, HCPs may improve caregiver mental health and prevent potential deterioration in physical health, decision-making, and ability to continue to provide care across the illness trajectory. Sleep interventions for caregivers of individuals with PMBT have been suggested previously (Pawl et al, 2013). With heightened awareness of the relationship of chronic sleep loss to certain aspects of caregiver health, HCPs can provide early recognition and intervention to improve caregiver sleep, health, and quality of life.…”

Section: Discussionmentioning

confidence: 99%

“…Reasons given for not participating included not being interested (51.6%), feeling too overwhelmed (32.8%), or other reasons (15.6%). Specifics of the eligibility criteria and sample characteristics have been reported elsewhere (Pawl et al, 2013). Briefly, caregivers were identified by care recipients as the person who would provide emotional and physical help on a regular basis.…”

Section: Methodsmentioning

confidence: 99%

“…Like other caregivers, caregivers of individuals with primary malignant brain tumor (PMBT) experience stress, depressive symptoms, and sleep impairments (Pawl, Lee, Clark, & Sherwood, 2013). Although PMBT occurs less frequently than other cancers, it is associated with disproportionate morbidity and mortality.…”

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confidence: 99%

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Sleep loss and its effects on health of family caregivers of individuals with primary malignant brain tumors

Pawl

Lee

Clark

et al. 2013

Research in Nursing & Health

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Sleep loss places caregivers at risk for poor health. Understanding correlates of sleep loss and relationships to health may enable improvement of health of caregivers of individuals with primary malignant brain tumors (PMBT). In this cross-sectional, descriptive study of 133 caregivers, relationships were examined between sleep loss and physical, mental, emotional, and social health at time of patient diagnosis. Sleep loss was not related to physical health. Shorter total sleep time was associated with greater fatigue and social support. Sleep quality was positively associated with quality of life. Further study is needed of the role of sleep loss in the PMBT caregiving trajectory and its long-term relationship with health outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Sleep loss and its effects on health of family caregivers of individuals with primary malignant brain tumors

Pawl

Lee

Clark

et al. 2013

Research in Nursing & Health

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“…Caregiver burden is reported to be high with more neuropsychiatric inventory symptoms present in the patient. Symptoms of agitation, depression, irritability, and disturbed night-time behavior are reported to influence the severity of the burden experienced by the caregiver [26,27] . Patients who are irritable and agitated are difficult to be convinced to do any activities because of their rebellious nature [5] .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Trends in the Neuropsychological Burden of Patients having Intracranial Tumors with Respect to Neurosurgical Intervention

et al. 2017

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Background: The burden of neuropsychological symptoms evidenced by behavioral changes among patients with intracranial tumors has not been studied in detail. Purpose: This study was conducted to prospectively assess the neuropsychological symptoms in patients with intracranial tumors undergoing treatment. Methods: A longitudinal study was conducted using purposive sampling to assess the neuropsychological symptoms in conscious and consenting patients with intracranial tumors who were availing treatment from a tertiary care center. Neuropsychiatric Inventory Questionnaire (NPI-Q), which identifies 12 behavioral disturbances, was assessed at baseline, and later at 1 month and 6 months after treatment, and scored as symptom severity as well as symptom scores. Results: Among the 34 patients studied, all had experienced at least one neuropsychological symptom. The commonest neuropsychological symptoms at baseline were anxiety (82%), agitation (75%), irritability (74%), depression (74%), and sleep disturbances (70%). The neuropsychiatric symptom and severity scores were 5.84 (SD ±2.7) and 11.8 (±7.1) at baseline, which reduced significantly to 4.3 (±3.1) and 5.6 (±3.2) at 1 month, and further to 2.3 (±2.9) and 3.6 (±3.2) at 6 months, respectively. The neuropsychological symptoms persistent at 6 months were anxiety (33%), depression (33%), sleep disturbances (33%), agitation (25%), irritability (25%), and disinhibition (25%). Conclusion: There is substantial neuropsychological burden among patients with intracranial tumors. The severity score improved immediately after surgery, while the symptom score improved gradually. The variable spectrum of improvement in neuropsychological symptoms at 6 months after surgical treatment needs further consideration. Addressing these symptoms should be one of the long-term goals of the neuro-oncology teams.

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“…Women adopt such behavior in disproportionately greater numbers in part because of lifelong demands on them as caregivers, first to their children and later to ailing and/or elderly family members 8, 9. Furthermore, psychosocial factors may disproportionally impact sleep among women compared with men.…”

Section: Introductionmentioning

confidence: 99%

Effects of Inadequate Sleep on Blood Pressure and Endothelial Inflammation in Women: Findings From the American Heart Association Go Red for Women Strategically Focused Research Network

Aggarwal

Makarem

Shah

et al. 2018

JAHA

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BackgroundInsufficient sleep increases blood pressure. However, the effects of milder, highly prevalent but frequently neglected sleep disturbances, including poor sleep quality and insomnia, on vascular health in women are unclear. We investigated whether poor sleep patterns are associated with blood pressure and endothelial inflammation in a diverse sample of women.Methods and ResultsWomen who participated in the ongoing American Heart Association Go Red for Women Strategically Focused Research Network were studied (n=323, 57% minority, mean age=39±17 years, range=20–79 years). Sleep duration, sleep quality, and time to sleep onset were assessed using the Pittsburgh Sleep Quality Index (score ≥5=poor sleep quality). Risk for obstructive sleep apnea was evaluated using the Berlin questionnaire, and insomnia was assessed using the Insomnia Severity Index. In a subset of women who participated in the basic study (n=26), sleep duration was assessed objectively using actigraphy, and endothelial inflammation was assessed directly in harvested endothelial cells by measuring nuclear translocation of nuclear factor kappa B. Vascular reactivity was measured by brachial artery flow‐mediated dilation (n=26). Systolic and diastolic blood pressure were measured by trained personnel (n=323). Multivariable linear regressions were used to evaluate associations between sleep patterns and blood pressure, nuclear factor kappa B, and flow‐mediated dilation. Mean sleep duration was 6.8±1.3 hours/night in the population study and 7.5±1.1 hour/night in the basic study. In the population study sample, 50% had poor sleep quality versus 23% in the basic study, and 37% had some level of insomnia versus 15% in the basic study. Systolic blood pressure was associated directly with poor sleep quality, and diastolic blood pressure was of borderline significance with obstructive sleep apnea risk after adjusting for confounders (P=0.04 and P=0.08, respectively). Poor sleep quality was associated with endothelial nuclear factor kappa B activation (β=30.6; P=0.03). Insomnia and longer sleep onset latency were also associated with endothelial nuclear factor kappa B activation (β=27.6; P=0.002 and β=8.26; P=0.02, respectively). No evidence was found for an association between sleep and flow‐mediated dilation.ConclusionsThese findings provide direct evidence that common but frequently neglected sleep disturbances such as poor sleep quality and insomnia are associated with increased blood pressure and vascular inflammation even in the absence of inadequate sleep duration in women.Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT02835261.

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Sleep Characteristics of Family Caregivers of Individuals With a Primary Malignant Brain Tumor

Cited by 43 publications

References 58 publications

Sleep loss and its effects on health of family caregivers of individuals with primary malignant brain tumors

Sleep loss and its effects on health of family caregivers of individuals with primary malignant brain tumors

Prevalence and Trends in the Neuropsychological Burden of Patients having Intracranial Tumors with Respect to Neurosurgical Intervention

Effects of Inadequate Sleep on Blood Pressure and Endothelial Inflammation in Women: Findings From the American Heart Association Go Red for Women Strategically Focused Research Network

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