Sleep-dependent consolidation patterns reveal insights into episodic memory structure

Oyanedel, Carlos N.; Sawangjit, Anuck; Born, Jan; Inostroza, Marion

doi:10.1016/j.nlm.2018.05.013

Cited by 9 publications

(5 citation statements)

References 47 publications

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“…Enhanced accessibility of object memories, on the other hand, might be a consequence of a systems consolidation process that involves a transformation of the originally encoded episodic representation of the task, such that the objects are more readily retrievable. Indeed, sleep is considered to support such active systems consolidation of episodic memory for events experienced in a spatiotemporal context ( 31 , 32 ), in which the hippocampus serves to bind the event representation into the spatial–temporal context. The repeated neuronal replay of spatial context information in hippocampal place cell ensembles during SWS epochs represents a core mechanism of sleep-dependent consolidation ( 7 , 10 , 33 , 34 ) that might foster the gradual transformation of the representation, such that it becomes more stably integrated within preexisting neocortical long-term memory, as well as with contextual information ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Two distinct ways to form long-term object recognition memory during sleep and wakefulness

Sawangjit

Harkotte

Oyanedel

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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Memory consolidation is promoted by sleep. However, there is also evidence for consolidation into long-term memory during wakefulness via processes that preferentially affect nonhippocampal representations. We compared, in rats, the effects of 2-h postencoding periods of sleep and wakefulness on the formation of long-term memory for objects and their associated environmental contexts. We employed a novel-object recognition (NOR) task, using object exploration and exploratory rearing as behavioral indicators of these memories. Remote recall testing (after 1 wk) confirmed significant long-term NOR memory under both conditions, with NOR memory after sleep predicted by the occurrence of EEG spindle–slow oscillation coupling. Rats in the sleep group decreased their exploratory rearing at recall testing, revealing successful recall of the environmental context. By contrast, rats that stayed awake after encoding showed equally high levels of rearing upon remote testing as during encoding, indicating that context memory was lost. Disruption of hippocampal function during the postencoding interval (by muscimol administration) suppressed long-term NOR memory together with context memory formation when animals slept, but enhanced NOR memory when they were awake during this interval. Testing remote recall in a context different from that during encoding impaired NOR memory in the sleep condition, while exploratory rearing was increased. By contrast, NOR memory in the wake rats was preserved and actually superior to that after sleep. Our findings indicate two distinct modes of long-term memory formation: Sleep consolidation is hippocampus dependent and implicates event-context binding, whereas wake consolidation is impaired by hippocampal activation and strengthens context-independent representations.

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Section: Discussionmentioning

confidence: 99%

Two distinct ways to form long-term object recognition memory during sleep and wakefulness

Sawangjit

Harkotte

Oyanedel

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

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“…Such a model may provide insight into memory biasing (e.g., using sensory cues) during sleep. Oyanedel et al (Oyanedel, Sawangjit, Born, & Inostroza, 2018) subjected rodents to two different learning paradigms ("what-where-when" and "what-where-which"), related to different aspects of episodic memory. While sleep was important for the consolidation in both the tasks, the benefit of sleep for memory consolidation was most prominent in the task, which included a temporal component (i.e.…”

Section: Neurobiological Features Of Sleep Conducive To Hippocampal Memory Consolidationmentioning

confidence: 99%

NLM Special Issue on Sleep and hippocampal function

Havekes¹,

Aton²,

Tudor³

et al. 2019

Neurobiology of Learning and Memory

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“…[12][13][14] Moreover, sleep deprivation also affects physical health, resulting in obesity, metabolic syndrome, and cardiovascular disease. [15][16][17] On the other hand, optimized sleep has been identified to be related to enhanced memory consolidation [18][19][20] and improved workplace performance. [21][22][23] Neuroscience research has demonstrated that sleep is important for the elimination of harmful proteins from the brain that may be related to the development of Alzheimer's disease.…”

Section: Introductionmentioning

confidence: 99%

Prioritization of Sleep: Discrepancies Between Attitude and Practice

Huang,

Lin,

Yang

2023

J Sleep Med

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Objectives: With the promotion of sleep through education, an increasing recognition of the importance of sleep among the general public has been observed. However, whether this increased recognition affects sleep practices is unknown. To provide direction for future sleep education programs, this study aimed to explore the consistency between people’s prioritization of sleep among their daily life activities and their actual practice when sleep conflicts with other activities.Methods: The study was a cross-sectional online survey with 898 adults (male:female=372:526; age=39.74±10.04 years). The participants were asked to complete an online survey that required them to 1) rate how important sleep was; 2) prioritize daily life activities including sleep, work, family activities, leisure activities, social activities, and exercise; and 3) recall the actions they undertook at the most recent instance when sleep conflicted with each of the other activities.Results: Although 70.7% of the participants prioritized sleep by placing it in their top three daily life activities, only 35.7% and 38.1% chose to go to sleep when it conflicted with work and family activities, respectively. Gender and occupational factors also significantly influenced the discrepancy between sleep attitudes and practices.Conclusions: Our study demonstrated an inconsistency between reporting sleep as a priority in daily life activities and actual behavioral practices when sleep conflicted with other activities. The results suggest that sleep education should not only emphasize the importance of sleep but also provide practical solutions for circumstances when sleep conflicts with other activities.

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Sleep-dependent consolidation patterns reveal insights into episodic memory structure

Cited by 9 publications

References 47 publications

Two distinct ways to form long-term object recognition memory during sleep and wakefulness

Two distinct ways to form long-term object recognition memory during sleep and wakefulness

NLM Special Issue on Sleep and hippocampal function

Prioritization of Sleep: Discrepancies Between Attitude and Practice

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