Sleep deprivation affects fear memory consolidation: bi-stable amygdala connectivity with insula and ventromedial prefrontal cortex

Feng, Pan; Becker, Benjamin; Zheng, Yong; Feng, Tingyong

doi:10.1093/scan/nsx148

Cited by 33 publications

(17 citation statements)

References 77 publications

(99 reference statements)

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“…It was observed that after undergoing SD, fear response increased during exposed to fear conditioning conditions such as PTSD ( Figure 2 A), suggesting that REM sleep-deprived rats are more sensitive to aversive stimuli (Albert et al, 1970 ). This supports previous findings of enhanced fear acquisition following SD, an SD-associated generalized failure to habituate during fear acquisition, and higher sensitivity to a negative stimulus in sleep-deprived rats (Anderson and Platten 2011 ; Peters et al 2014 ; Feng et al 2018 ). This increase in exposure to fear is linked to an increase in vulnerability to SD, which has also been suggested in previous human studies (Lautenbacher et al 2006 ).…”

Section: Discussionsupporting

confidence: 91%

Alteration of fear behaviors in sleep-deprived adolescent rats: increased fear expression and delayed fear extinction

Jung

Noh

2021

Animal Cells and Systems

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Disruption of sleep due to acute or chronic stress can lead to changes in emotional memory processing. Sleep disturbances are highly prevalent in post-traumatic stress disorder (PTSD), but still, the contribution of sleep deprivation on the susceptibility to PTSD has received little attention. To determine whether rapid eye movement sleep deprivation (SD) alters the development of fear expression or fear-associated memory impairment in adolescent rats, we performed animal emotional behavior tests using an SD animal model with the flowerpot technique. SD rats showed an increase in locomotor activity frequency and a decrease in sucrose consumption compared to control rats. An increase in freezing behavior during shock trials was observed in SD rats. Noticeably, it was observed that when applying the SD condition after fear stimuli exposure, fear extinction was delayed more in SD rats than in control rats. Overall, these results indicate that SD in adolescent rats leads to increased locomotor activity and anhedonic behavior, as well as increased fear expression and delayed fear extinction, suggesting that SD would lead to increased severity of PTSD-like phenotype.

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Section: Discussionsupporting

confidence: 91%

Alteration of fear behaviors in sleep-deprived adolescent rats: increased fear expression and delayed fear extinction

Jung

Noh

2021

Animal Cells and Systems

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“…In addition, there is recent evidence that sleep deprivation prevents the inhibition of amygdala activity by the vmPFC during fear consolidation (Feng, Becker, Zheng, & Feng, 2018). With the amygdala-hippocampus-mPFC network showing greatest activation during REM sleep (Genzel, Spoormaker, Konrad, & Dresler, 2015), this cortical network could speculatively play an important role in fear reinstatement via cortical activity during REM sleep.…”

Section: Discussionmentioning

confidence: 99%

Greater sleep disturbance and longer sleep onset latency facilitate SCR-specific fear reinstatement in PTSD

Zuj

Palmer

Malhi

et al. 2018

Behaviour Research and Therapy

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Fear reinstatement is one of several paradigms designed to measure fear return following extinction, as a laboratory model for the relapse of Posttraumatic Stress Disorder (PTSD) symptoms. Sleep is a key factor in emotional memory consolidation, and here we examined the relationship between sleep quality and fear reinstatement in PTSD, relative to trauma-exposed and non-exposed controls. The Pittsburgh Sleep Quality Index (PSQI) was used as a subjective measure of sleep quality, and skin conductance responses (SCR) and unconditioned stimulus (US)-expectancy ratings were used to index threat responses during a differential fear conditioning, extinction, and reinstatement paradigm. There were no significant between-group differences in the reinstatement of conditioned responding. Sleep disturbance and sleep onset latency were significant moderators between reinstatement of fear and PTSD symptom severity, such that there was a positive relationship between PTSD symptoms and fear reinstatement for higher levels - but not lower levels - of sleep disturbance and sleep onset latency. To our knowledge, this is the first study to investigate PTSD-specific reinstatement patterns and sleep as a boundary condition of reinstatement. Future research using polysomnographic measures of sleep-wave architecture may further clarify the relationship between fear reinstatement and sleep quality in clinical samples with PTSD relative to controls.

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“…• Increases the number of false memories recalled (Frenda, Patihis, Loftus, Lewis, & Fenn, 2014). • Amplifies the effects of physical pain (Lautenbacher, Kundermann, & Krieg, 2006;Schrimpf et al, 2015) • Increases fear-memory consolidation and post-traumatic stress symptoms (Feng, Becker, Zheng, & Feng, 2018).…”

Section: Introductionmentioning

confidence: 99%

The 6/24 rule: A review and proposal for an international standard of a minimum of six hours of continuous sleep in detention settings

Pérez–Sales

2019

torture

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Sleep deprivation is one of the most prevalent and widely used methods of psychological torture. Its effects on the body are without direct physical aggression and include significant somatic and psychological impacts and suffering. It is used in multiple coercive environments as a way, among other purposes, of degradation, debilitation, punishment or before and during the interrogation of detainees. In this specific context, it produces cognitive, emotional and physical exhaustion, with the aim of obtaining submission or compliance, and ultimately information or confession (Pérez-Sales, 2017; Reynolds & Banks, 2010; Sveaass, 2008). There is no universally accepted legal definition of what should be considered sleep deprivation in the context of torture. There are however converging positions from the legal and jurisprudential, and especially medical and psychiatric fields that allow for establishing sufficiently clear recommendations for the international community to take a reasoned stance. Within the framework of torture as defined in the United Nations Convention (UNCAT), intentionally forcing a person to have less than 6 hours of continuous, restful sleep must be considered a form of degrading treatment that could amount to cruel and inhuman treatment. We also suggest that when this daily sleep deprivation is intentionally prolonged in a sustained manner for three days or more, it should be considered as a form of torture in itself, irrespective of other coexisting or cumulative elements that may aggravate the condition.

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Sleep deprivation affects fear memory consolidation: bi-stable amygdala connectivity with insula and ventromedial prefrontal cortex

Cited by 33 publications

References 77 publications

Alteration of fear behaviors in sleep-deprived adolescent rats: increased fear expression and delayed fear extinction

Alteration of fear behaviors in sleep-deprived adolescent rats: increased fear expression and delayed fear extinction

Greater sleep disturbance and longer sleep onset latency facilitate SCR-specific fear reinstatement in PTSD

The 6/24 rule: A review and proposal for an international standard of a minimum of six hours of continuous sleep in detention settings

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