Sleep deprivation during pregnancy and maternal and fetal outcomes: Is there a relationship?

Chang, Jen Jen; Pien, Grace W.; Duntley, Stephen P.; Macones, George A.

doi:10.1016/j.smrv.2009.05.001

Cited by 279 publications

(245 citation statements)

References 60 publications

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“…pregnancy and delivery outcomes (eg, preterm delivery, prolonged labor, cesarean section deliveries, and postpartum depression). [15][16][17] Therefore, the goal of this study was twofold: (1) to examine the frequency of RLS in a large, heterogeneous sample of pregnant women using standardized diagnostic criteria for RLS; and (2) to investigate the role of RLS in sleep-wake disturbances (ie, poor sleep quality, excessive daytime sleepiness, and poor daytime function) in addition to key delivery outcomes. …”

mentioning

confidence: 99%

Restless Legs Syndrome and Sleep-Wake Disturbances in Pregnancy

Dunietz

Lisabeth²,

Shedden³

et al. 2017

Journal of Clinical Sleep Medicine

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Study Objectives: To estimate the association of restless legs syndrome (RLS) and its frequency with sleep-wake disturbances in pregnancy. Methods: A cohort of 1,563 women in their third trimester of pregnancy were recruited from prenatal clinics between March 2007 and December 2010. Demographic, pregnancy, and delivery data were extracted from medical records and sleep information was collected with questionnaires. To diagnose RLS, we used standardized criteria of RLS symptoms and frequency that were developed by the International Restless Legs Study Group. Logistic regression models were constructed to investigate the association of RLS and its frequency with sleep-wake disturbances (poor sleep quality, daytime sleepiness, poor daytime function) and delivery outcomes. Results: Overall 36% of the pregnant women had RLS, and half had moderate to severe symptoms. Compared to women without RLS, those with RLS were more likely to have poor sleep quality (odds ratio [OR] 2.2, 95% confidence interval [CI] 1.7-2.9), poor daytime function (OR 1.9, 95% CI 1.4-2.4), and excessive daytime sleepiness (OR 1.6, 95% CI 1.3-2.0). A dose-response relationship also was evident between RLS frequency and each of the sleep-wake disturbances. There was no evidence for any association between RLS and delivery outcomes. Conclusions: RLS is a significant contributor to poor sleep quality, daytime sleepiness, and poor daytime function, all common and often debilitating conditions in pregnancy. Obstetric health care providers should be aware of these associations and screen women for RLS. I NTRO DUCTI O NRestless legs syndrome (RLS), also known as Willis-Ekbom disease, is a sensorimotor disorder composed of an urge to move, with or without associated discomfort that occurs with inactivity and improves with movement. It follows a circadian pattern, with a predilection for the evening and night.1 RLS is a common, underdiagnosed condition that affects up to 5% of the population worldwide, 2-4 with up to 15% prevalence in Caucasians. 5 The prevalence of RLS is positively correlated with age and body mass index (BMI) among both men and women.6,7 Although RLS has a genetic predisposition, it is also associated with other conditions such as end-stage renal disease, neuropathy, and pregnancy. 8 RLS affects up to one-third of pregnant women 9,10 peaks in the third trimester, 9-11 and usually subsides after delivery. 11Multiparous women are affected up to three times more often than nulliparous women. 10 The high prevalence of RLS during pregnancy has been attributed to hemodynamic and hormonal changes, iron and folate metabolism, and psychomotor behaviors.12 Although RLS is related to reduced quality of life and poor sleep in the general population 13,14 data on RLSassociated maternal sleep-wake disturbances are lacking. pregnancy and delivery outcomes (eg, preterm delivery, prolonged labor, cesarean section deliveries, and postpartum depression). [15][16][17] Therefore, the goal of this study was twofold: (1) to examine the frequency of RLS in ...

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mentioning

confidence: 99%

Restless Legs Syndrome and Sleep-Wake Disturbances in Pregnancy

Dunietz

Lisabeth²,

Shedden³

et al. 2017

Journal of Clinical Sleep Medicine

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“…6,7 Indeed, sleep disturbances and a depressed mood are more common and the frequency of Caesarean delivery is higher among women with RLS than among those without. 8,9 Medications for treatment of RLS symptoms and their safety in pregnancy are summarised in Table 2. 10 Dopaminergic drugs are generally the first-line agents and include levodopa, bromocriptine, pergolide, pramipexole, ropinirole, and cabergoline.…”

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confidence: 99%

Restless Legs Syndrome with Severe Limb Pain during Pregnancy

et al. 2014

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Herein we report a case of restless legs syndrome (RLS) during pregnancy in a 32-year-old woman who began feeling pain in her feet at night at 30 weeks of gestation. She could relieve the pain by moving her legs, but her symptoms worsened, preventing sleep. She was diagnosed with pregnancy-related RLS. Neither carbamazepine nor gabapentin alleviated her symptoms effectively, but the discomfort spontaneously improved two months after delivery. RLS during pregnancy leads to sleep disorders, which are associated with adverse pregnancy outcomes. More attention should be given to RLS during pregnancy.

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“…MÉTODOS: Estudo transversal incluindo 223 gestantes com ≥14 semanas: 105 com sobrepeso (índice de massa corporal -IMCpré-gestacional ≥25,0 km 2 ) e 118 eutróficas (IMC 18,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)9 kg/m 2 ) em acompanhamento pré-natal. A versão brasileira do questionário Pittsburgh Sleep Quality Index (PSQI-BR) foi utilizada para avaliação do sono.…”

Section: Introductionunclassified

“…As alterações do sono durante a gestação têm sido associadas a diversos problemas de saúde para o binômio materno-fetal. A insônia durante a gestação está associada a depressão e ansiedade no final da gestação e do puerpério 14,15 , baixa produtividade diurna e riscos para a segurança 15 , parto pré-termo 16,17 , trabalho de parto prolongado e cesárea 18,19 . A insônia pode ainda alterar o relacionamento da gestante com o parceiro e a família 20 .…”

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Qualidade do sono em gestantes com sobrepeso

Ribeiro¹,

Nakamura²,

Torloni³

et al. 2015

Rev. Bras. Ginecol. Obstet.

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ResumoOBJETIVO: Comparar a qualidade do sono de gestantes com e sem sobrepeso no segundo e terceiro trimestres. MÉTODOS: Estudo transversal incluindo 223 gestantes com ≥14 semanas: 105 com sobrepeso (índice de massa corporal -IMCpré-gestacional ≥25,0 km 2 ) e 118 eutróficas (IMC 18,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)9 kg/m 2 ) em acompanhamento pré-natal. A versão brasileira do questionário Pittsburgh Sleep Quality Index (PSQI-BR) foi utilizada para avaliação do sono. Testes do χ 2 e t de Student foram utilizados para comparar diferenças entre os grupos; p<0,05 foi considerado significante. RESULTADOS: A maioria (65,9%) apresentou baixa qualidade de sono (escore total >5) e essa proporção foi significativamente mais alta entre as mulheres com sobrepeso (80/105), em comparação às eutróficas (67/118) (76,2 versus 56,8%, p=0,004). No 2º trimestre, essa proporção não alcançou significância estatística (72,5 versus 53,7%, p=0,06), mas o escore médio total do PSQI-BR foi mais alto entre aquelas com sobrepeso (7,0±3,8 versus 5,5±3,2, p=0,02). Nesse período, os escores médios de latência e qualidade subjetiva do sono foram significativamente mais altos entre as mulheres com sobrepeso (1,4±1,0 versus 1,0±0,9, p=0,02, e 1,3±0,8 versus 0, 8±0,8, p=0,02, respectivamente). No 3º trimestre, a proporção de gestantes com baixa qualidade do sono foi mais alta entre as mulheres com sobrepeso, mas sem diferença significante (79,6 versus 60,8%, p=0,06). Nessa fase, o escore total do instrumento foi semelhante entre as mulheres com e sem sobrepeso (9,4±4,2 versus 8,3±4,6, p=0,2). No entanto, gestantes com sobrepeso apresentaram escores médios mais altos para distúrbios do sono (2,3±0,7 versus 2,0±0,8, p=0,04). CONCLUSÃO: Mulheres com sobrepeso pré-gestacional apresentaram sono mais comprometido do que as eutróficas, no segundo e terceiro trimestres da gravidez. Abstract PURPOSE:To compare sleep quality of overweight versus normal weight women in the second and third trimesters of pregnancy. METHODS: A cross-sectional study involving 223 women with 14 or more weeks of pregnancy, 105 of them overweight (pre-pregnancy body mass index -BMI -≥25.0 kg/m 2 ) and 118 of normal weight (BMI 18.5-24.9 kg/m 2 ), attending the prenatal care clinic. The Brazilian version of the Pittsburgh Sleep Quality Index (PSQI-BR) questionnaire was used to evaluate sleep quality. The Student t-test and the chi-square test were used to compare differences between groups and a p value <0.05 was considered statistically significant. RESULTS: Most of the participants (67.7%) were poor sleepers (total score >5); this proportion was significantly higher among overweight (80/105) versus normal weight (67/118) women (76.2 versus 56.8%, p=0,004). During the second trimester, this difference did not reach statistical significance (72.5 versus 53.7%, respectively, p=0.06) but mean total PSQI-BR scores were significantly higher among overweight participants (7.0±3.8 versus 5.5±3.2, p=0.02). In the 2 nd trimester, overweight women a...

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Sleep deprivation during pregnancy and maternal and fetal outcomes: Is there a relationship?

Cited by 279 publications

References 60 publications

Restless Legs Syndrome and Sleep-Wake Disturbances in Pregnancy

Restless Legs Syndrome and Sleep-Wake Disturbances in Pregnancy

Restless Legs Syndrome with Severe Limb Pain during Pregnancy

Qualidade do sono em gestantes com sobrepeso

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