Sleep Deprivation in Rats Produces Attentional Impairments on a 5-Choice Serial Reaction Time Task

Córdova, Christopher Andy; Said, Bishoy; McCarley, Robert W.; Baxter, Mark G.; Chiba, Andrea A.; Strecker, Robert E.

doi:10.1093/sleep/29.1.69

Cited by 16 publications

(2 citation statements)

References 63 publications

(77 reference statements)

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“…Acute sleep deprivation is less common than sleep restriction or sleep fragmentation as a means for increasing sleepiness in adolescents. However, acute sleep deprivation can provide an experimental model for inducing similar sleepiness to sleep restriction and fragmentation as measured behavioral and chemically (Córdova et al, 2006; Deurveilher, Bush, Rusak, Eskes, & Semba, 2015; Kim et al, 2012; McKenna et al, 2007). It should also be noted that although both sleep deprived and control juvenile rats eventually reached similar performance and recall in the water maze, the platform location did remain constant over the course of many learning trials.…”

Section: Discussionmentioning

confidence: 99%

“…Another possible explanation for the present results is that juvenile rats may have had impaired attention which slowed their ability to learn the task. Sleep loss does negatively impact measures of attention in rodents (Christie, McKenna, Connolly, McCarley, & Strecker, 2008; Córdova et al, 2006). However, as recently reviewed by Kreutzmann and colleagues (Kreutzmann et al, 2015), there is ample evidence that the disruption of sleep impacts neural plasticity within the hippocampus by changing molecular functions.…”

Section: Discussionmentioning

confidence: 99%

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Effects of sleep deprivation on spatial learning and memory in juvenile and young adult rats.

Ward¹,

Wooden²,

Kieltyka³

2017

Psychology & Neuroscience

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Sleepiness is commonly seen in adolescents and can negatively impact school performance. Little research has investigated the impact of sleepiness in juvenile animals on spatial learning. Sprague-Dawley juvenile (<30 days) and young adult (>60 days) rats were sleep deprived for 24 hours and tested, along with controls, in a water maze task. Sleep deprived juveniles were slower to learn the location of the hidden platform than controls; however, adult performance was not impaired. Sleep deprivation did not impair recall during a probe trial for either age group. Sleep deprivation prior to testing slowed spatial learning in juveniles but not adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of sleep deprivation on spatial learning and memory in juvenile and young adult rats.

Ward¹,

Wooden²,

Kieltyka³

2017

Psychology & Neuroscience

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Distinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617

et al. 2015

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While treatment options are available, excessive daytime sleepiness (EDS) remains a significant unmet medical need for many patients. Relatively little rodent behavioural pharmacology has been conducted in this context to assess potential pro-vigilant compounds for their ability to restore functional capacity following experimentally induced sleep loss. Male Wistar rats were prepared for electroencephalographic (EEG) recording and subject to 11 h of sleep restriction using a biofeedback-induced cage rotation protocol. A simple response latency task (SRLT) was used to behaviourally index sleep restriction and the effects of pro-vigilant compounds: modafinil, d-amphetamine, caffeine, and the mGlu5-positive allosteric modulator LSN2814617. Sleep restriction resulted in a consistent, quantified loss of non-rapid eye movement (NREM) and REM sleep that impaired SRLT performance in a manner suggestive of progressive task disengagement. In terms of EEG parameters, all compounds induced wakefulness. Amphetamine treatment further decreased SRLT performance capacity, whereas the other three compounds decreased omissions and allowed animals to re-engage in the task. Caffeine and modafinil also significantly increased premature responses during this period, an effect not observed for LSN2814617. While all compounds caused compensatory sleep responses, the magnitude of compensation observed for LSN2814617 was much smaller than would be predicted to result from the prolongation of wakefulness exhibited. Using simple response latencies to index performance, an mGlu5 PAM dramatically increased wakefulness and improved functional capacity of sleep-restricted animals, without eliciting a proportionate compensatory sleep response. This effect was qualitatively distinct from that of amphetamine, caffeine and modafinil.Electronic supplementary materialThe online version of this article (doi:10.1007/s00213-015-3936-8) contains supplementary material, which is available to authorized users.

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Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline

et al. 2016

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RationaleMembers of the c-Jun N-terminal kinase (JNK) family of mitogen-activated protein (MAP) kinases, and the upstream kinase MKK7, have all been strongly linked with synaptic plasticity and with the development of the neocortex. However, the impact of disruption of this pathway on cognitive function is unclear.ObjectiveIn the current study, we test the hypothesis that reduced MKK7 expression is sufficient to cause cognitive impairment.MethodsAttentional function in mice haploinsufficient for Map2k7 (Map2k7 +/− mice) was investigated using the five-choice serial reaction time task (5-CSRTT).ResultsOnce stable performance had been achieved, Map2k7 +/− mice showed a distinctive attentional deficit, in the form of an increased number of missed responses, accompanied by a more pronounced decrement in performance over time and elevated intra-individual reaction time variability. When performance was reassessed after administration of minocycline—a tetracycline antibiotic currently showing promise for the improvement of attentional deficits in patients with schizophrenia—signs of improvement in attentional performance were detected.ConclusionsOverall, Map2k7 haploinsufficiency causes a distinctive pattern of cognitive impairment strongly suggestive of an inability to sustain attention, in accordance with those seen in psychiatric patients carrying out similar tasks. This may be important for understanding the mechanisms of cognitive dysfunction in clinical populations and highlights the possibility of treating some of these deficits with minocycline.Electronic supplementary materialThe online version of this article (doi:10.1007/s00213-016-4463-y) contains supplementary material, which is available to authorized users.

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Sleep Deprivation in Rats Produces Attentional Impairments on a 5-Choice Serial Reaction Time Task

Cited by 16 publications

References 63 publications

Effects of sleep deprivation on spatial learning and memory in juvenile and young adult rats.

Effects of sleep deprivation on spatial learning and memory in juvenile and young adult rats.

Distinct pro-vigilant profile induced in rats by the mGluR5 potentiator LSN2814617

Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline

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