Sleep Deprivation Is Hyperalgesic in Patients With Gastroesophageal Reflux Disease

Schey, Ron; Dickman, Ram; Parthasarathy, Sairam; Quan, Stuart F.; Wendel, Christopher; Merchant, Jonah; Powers, Jeannette; Han, Bing; Handel, Daniel Van; Fass, Ronnie

doi:10.1053/j.gastro.2007.09.039

Cited by 186 publications

(130 citation statements)

References 29 publications

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“…There are many clinical studies that have evaluated the relationship between GERD and sleep disturbances. 31,32 Schey et al 33 performed an experimental study and demonstrated the effect of sleep deprivation on perception of intraesophageal acid infusion. Shorter sleep duration (≤ 3 hours) decreased the latency and increased the intensity of GERD symptoms induced by intra-esophageal acid infusion compared with longer sleep duration (≥ 7 hours).…”

Section: Discussionmentioning

confidence: 99%

“…The authors suggested that sleep deprivation could cause esophageal hyperalgesia. 31,33 Overall sleep quality, including sleep duration, may be associated with more severe GERD symptoms and could influence response to PPI therapy in GERD patients. 33 A previous study by the authors of the present paper demonstrated that poor sleep quality is more strongly associated with NERD than with ERD.…”

Section: Discussionmentioning

confidence: 99%

“…31,33 Overall sleep quality, including sleep duration, may be associated with more severe GERD symptoms and could influence response to PPI therapy in GERD patients. 33 A previous study by the authors of the present paper demonstrated that poor sleep quality is more strongly associated with NERD than with ERD. 18 Therefore, NERD, a risk factor of poor response to PPI treatment in GERD patients, could also be related to sleep disturbances.…”

Section: Discussionmentioning

confidence: 99%

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Predictive Factors of Response to Proton Pump Inhibitors in Korean Patients With Gastroesophageal Reflux Disease

Kim

et al. 2015

J Neurogastroenterol Motil

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Background/Aims Proton pump inhibitors (PPIs) are widely used in the treatment of gastroesophageal reflux disease (GERD). However, some patients fail to respond to PPI therapy. We investigated the efficacy of response to PPI therapy in patients with GERD symptoms. Methods A total of 179 subjects with GERD symptoms were prospectively enrolled and diagnosed with non-erosive reflux disease (NERD, n = 100) and erosive reflux disease (n = 79) by gastroscopy and Bernstein test and/or 24-hour esophageal pH testing. Subjects then received a standard dose of daily PPI therapy for at least 4 weeks. PPI therapy response was evaluated using questionnaires including questions about demographics, GERD symptoms, GERD impact scale, Epworth sleepiness scale, Pittsburgh sleep quality index (PSQI), hospital anxiety and depression scale, and abbreviated version of the World Health Organization quality of life scale. Results The rates of complete (≥ 80%), satisfactory (≥ 50%), partial (< 50%), and refractory response in the 179 participants were 41.3%, 30.2%, 18.4%, and 10.1%, respectively. Thus, overall response rate (complete and satisfactory responses) was 71.5%. Multivariate analysis showed body mass index < 23 kg/m 2 (OR, 2.20; 95% CI, 1.12–4.34), higher total PSQI score (OR, 1.20; 95% CI, 1.05–1.35), history of psychotherapy or neuropsychiatric medication (OR, 2.44; 95% CI, 1.23–4.85), and NERD (OR, 3.30; 95% CI, 1.54–7.11) were associated with poor response to PPI therapy. Conclusions Psychological factors, sleep dysfunction, body mass index < 23 kg/m 2 , and NERD seem to be the major factors that lead to a poor response to PPI treatment in patients with GERD symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Predictive Factors of Response to Proton Pump Inhibitors in Korean Patients With Gastroesophageal Reflux Disease

Kim

et al. 2015

J Neurogastroenterol Motil

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“…Recently, acute stress has been shown to reduce oesophageal perception thresholds for pain resulting in low-intensity stimuli perceived as being painful. 7 Neurobiological mechanisms stimulated by prolonged stress events, such as sexual abuse, may result in reduced perception threshold for pain and consequently increased oesophageal hypersensitivity to pathological and even physiological events. 8 Additionally, prolonged stress may also lead to hypervigilance and thus over-reporting of stimulus intensity.…”

Section: Introductionmentioning

confidence: 99%

Review article: gastro‐oesophageal reflux disease and psychological comorbidity

Mizyed

Fass

2009

Aliment Pharmacol Ther

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“…Furthermore, sleep deprivation and auditory stress were reported to enhance unpleasant reflux symptoms [Fass et al 2008;Schey et al 2007]. Therefore, drugs that decrease anxiety and stress may be useful for PPI-resistant NERD, and a study to investigate the value of these types of drugs is necessary.…”

Section: Nonacid Reflux Causing Reflux Symptomsmentioning

confidence: 99%

Review: Causes of, and therapeutic approaches for, proton pump inhibitor-resistant gastroesophageal reflux disease in Asia

Kinoshita

Ishihara

2008

Therap Adv Gastroenterol

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Proton pump inhibitors (PPIs) are the most widely used drugs for treatment of gastroesophageal reflux disease. However, approximately 20% of patients with reflux esophagitis and 40% of those with nonerosive reflux diseases complain of troublesome symptoms, even during treatment with PPIs. In patients with reflux esophagitis, dose escalation and co-administration with a histamine H 2 -receptor antagonist are potential approaches, since the major cause of PPI resistance is incomplete suppression of gastric acid secretion. On the other hand, for patients with nonerosive reflux disease, switching from PPIs to pain modulators is often necessary for improvement of symptoms, since 25% of patients with nonerosive reflux disease have symptoms not caused by gastroesophageal acid reflux. Therapeutic approaches for PPI-resistant patients with reflux esophagitis and nonerosive reflux diseases are considered according to pathogenesis.

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Sleep Deprivation Is Hyperalgesic in Patients With Gastroesophageal Reflux Disease

Cited by 186 publications

References 29 publications

Predictive Factors of Response to Proton Pump Inhibitors in Korean Patients With Gastroesophageal Reflux Disease

Predictive Factors of Response to Proton Pump Inhibitors in Korean Patients With Gastroesophageal Reflux Disease

Review article: gastro‐oesophageal reflux disease and psychological comorbidity

Review: Causes of, and therapeutic approaches for, proton pump inhibitor-resistant gastroesophageal reflux disease in Asia

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