Sleep deprivation predisposes allergic mice to neutrophilic lung inflammation

Nunes, Jethe O.F.; Apostólico, Juliana de Souza; Andrade, David A. G.; Ruiz, Francieli Silva; Fernandes, Edgar Ruz; Andersen, Mônica Levy; Keller, Alexandre C.; Rosa, Daniela Santoro

doi:10.1016/j.jaci.2017.06.025

Cited by 32 publications

(31 citation statements)

References 46 publications

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“…Diverse mechanisms may be presumed for sleep deprivation to affect the exacerbation of allergic reactions. As is well known, sleep deprivation is associated with chronic inflammation, nervous or hormonal imbalance, and immunologic change [8,9,11,12]. These can cause or worsen allergic responses.…”

Section: Discussionmentioning

confidence: 99%

“…They found that REM sleep is related to nocturnal asthma, probably because of changes in sympathetic modulation. Nunes et al [9] examined the effect of sleep deprivation on allergen-induced airway inflammation in an ovalbumin (OVA)-sensitized mice model and reported that there were severe lung inflammation in the sleepdeprived OVA-sensitized mice group compared to the control group. In detail, their results indicated that sleep deprivation is related to elevated IL-17 levels, pulmonary neutrophilia, and resistance to corticosteroid therapy.…”

Section: Discussionmentioning

confidence: 99%

“…A few studies have investigated the link between sleep deprivation and allergic inflammatory response in animal models [8,9]. However, it is not fully known about the relationship between sleep deprivation and allergic inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Sleep Deprivation on the Inflammatory Response in Rats: A Pilot Study

et al. 2020

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We aimed to identify the association between sleep deprivation and inflammatory response. Fourteen-week old male Wistar rats were used randomly assigned to a sleep deprivation [sleep deprivation (SD) group, n = 3] or a control [healthy sleep (HS) group, n = 3] group. To induce sleep deprivation, we used a modified multiple platform method. We examined serum interleukin-1beta (IL-1β), corticosterone, the number of inflammatory cells in broncho-alveolar lavage fluid (BALF), and the histopathology of the pulmonary parenchyma (peri-bronchiolar infiltration) between the SD and the HS groups. The SD group showed an increase in serum IL-1β, corticosterone, the number of neutrophil and eosinophil in BALF, and peri-bronchiolar infiltration of eosinophils compared to the HS group. However, serum IL-1β and the number of inflammatory cells in BALF, except for corticosterone and eosinophil in lung parenchyma, were statistically insignificant. We suggest that SD may be associated with worsening of allergic inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of Sleep Deprivation on the Inflammatory Response in Rats: A Pilot Study

et al. 2020

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“…Sleep deprivation was performed using a modi ed multiple platform method [24,25]. Mice were placed in a ventilated transparent cage (50 × 30 × 17cm; 3 mice/cage) containing 9 circular platform (3.5cm in diameter) surrounded by water up to 1cm beneath the upper surface of the platforms enabling the mice to move between the platforms.…”

Section: Sleep Deprivation Modelmentioning

confidence: 99%

A key role of gut microbiota-vagus nerve axis and gut microbiota-spleen axis in sleep deprivation-mediated aggravation of systemic inflammation after LPS administration

Zhang

Xie

et al. 2020

Preprint

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Background: Sleep deprivation (SD) is shown to be correlated with exacerbated systemic inflammation after sepsis. However, the underlying mechanisms remain unclear. Methods: In this study, mice were intraperitoneally injected with lipopolysaccharide (LPS) followed by 3 consecutive days of SD. The subdiaphragmatic vagotomy (SDV) was performed 2 weeks before LPS injection. The pseudo germ-free mouse model was created by administering antibiotics for 14 consecutive days, and then fecal microbiota transplant (FMT) was performed by gavaging supernatant from fecal suspension of septic mice with or without SD into pseudo germ-free mice with or without SDV or splenectomy. Splenectomy was performed 14 days prior to antibiotics administration.Results: We found that SD after LPS administration increased the plasma levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), reduced IL-10 plasma leve, increased spleen weight, and promoted pathological injury and IL-6 expression in lung, liver and kidney. Post-septic sleep deprivation had no effects on the diversity of gut microbiota. However, the relative abundance of Proteobacteria and its subgroups were increased in septic mice received SD. Pseudo germ-free mice transplanted with fecal bacteria from septic mice subjected to SD developed splenomegaly, systemic inflammation, organ inflammation and damage as their donors do. Intriguingly, SDV abolished the aggravated effects of SD on splenomegaly and inflammatory organ injury in septic mice received SD or in pseudo germ-free mice transplanted with fecal bacteria from septic mice subjected to SD. Furthermore, Splenectomy also abrogated the increase in IL-6 and TNF-α plasma levels and the decrease in IL-10 plasma level in pseudo germ-free mice transplanted with fecal bacteria from septic mice subjected to SD. Conclusions: Taken together, our results suggest that gut microbiota-vagus nerve axis and gut microbiota-spleen axis could play key roles in modulating systemic inflammation induced by SD after LPS administration.

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“…We know that during sleep there is production of pro-and anti-inflammatory cytokines, however, production of inflammatory cytokines is observed in sleep deprivation. In the experimental study by Nunes et al [2], it was possible to demonstrate that mice in sleep deprivation had more inflammatory cytokines than those allowed for good quality sleep. In addition, mice in sleep deprivation after corticotherapy (dexamethasone) were not able to reduce production of IL-17 and TNFalpha in the same way as mice that had good quality of sleep.…”

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confidence: 99%

Correspondence COVID-19: Melatonin as a potential adjuvant treatment

Salles

2020

Life Sciences

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Sleep deprivation predisposes allergic mice to neutrophilic lung inflammation

Abstract: Collectively, our data show that sleep quality participates in the progression of allergen-induced eosinophilic lung inflammation to corticosteroid-refractory neutrophilic manifestation.

Cited by 32 publications

References 46 publications

Effect of Sleep Deprivation on the Inflammatory Response in Rats: A Pilot Study

Effect of Sleep Deprivation on the Inflammatory Response in Rats: A Pilot Study

A key role of gut microbiota-vagus nerve axis and gut microbiota-spleen axis in sleep deprivation-mediated aggravation of systemic inflammation after LPS administration

Correspondence COVID-19: Melatonin as a potential adjuvant treatment

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