Sleep deprivation reduces the lymphocyte count in a non-obese mouse model of type 1 diabetes mellitus

Ruiz, Francieli Silva; Andersen, M.L.; Zager, Adriano; Martins, Rui C.; Tufik, Sérgio

doi:10.1590/s0100-879x2007000500005

Cited by 31 publications

(5 citation statements)

References 11 publications

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“…Epidemiological data indicate that sleep deprivation has a mutually conditional relationship, e.g. pain leads to insomnia and sleep deficiency decreases the pain threshold and contributes to the extended periods of wound healing (Mostaghimi et al ., ), to the reduction of growth hormone (Ruiz et al ., ) and to affecting metabolic, endocrine and immunological responses (Spiegel et al ., ). Studies confirm an increased incidence of hypertension, heart rate (Arora et al ., ), the presence of delirium and confusion (Figueroa‐Ramos et al ., ; Patel et al ., ), a decreased performance in daily activities and reduced quality of life, as determined by a questionnaire completed by patients (Martin et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Effect of the use of earplugs and eye mask on the quality of sleep in intensive care patients: a systematic review

Locihová

Axmann

Padyšáková

et al. 2017

Journal of Sleep Research

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Intensive care unit (ICU) environment has a very strong and unavoidable negative impact on patients' sleep. Sleep deprivation in ICU patients has been already studied and negative effects on their outcome (prolonged ICU stay, decreased recovery) and complication rates (incidence of delirium, neuropsychological sequels of critical illness) discussed. Several interventions potentially improving the sleep disturbance in ICU (sleep-promotion strategies) have been assumed and tested for clinical practice. We present a review of recent literature focused on chosen types of non-pharmacological interventions (earplugs and eye mask) analysing their effect on sleep quality/quantity. From the total amount of 82 papers found in biomedical databases (CINAHL, PubMed and SCOPUS) we included the 19 most eligible studies meeting defined inclusion/exclusion criteria involving 1 379 participants. Both experimental and clinical trials, either ICU and non-ICU patient populations were analysed in the review. Most of the reviewed studies showed a significant improvement of subjective sleep quality when using described non-pharmacological interventions (objective parameters were not significantly validated). Measuring the sleep quality is a major concern limiting the objective comparison of the studies' results since non-standardised (and mainly individual) tools for sleep quality assessment were used. Despite the heterogeneity of analysed studies and some common methodological issues (sample size, design, outcome parameters choice and comparison) earplugs and eye mask showed potential positive effects on sleep quality and the incidence of delirium in ICU patients.

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Section: Introductionmentioning

confidence: 99%

Effect of the use of earplugs and eye mask on the quality of sleep in intensive care patients: a systematic review

Locihová

Axmann

Padyšáková

et al. 2017

Journal of Sleep Research

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“…The primary function of sleep remains unknown, but the fact that prolonged sleep deprivation results in the death of experimental animals indicates that it is essential for survival (Rechtschaffen, ). Reinforcing the importance of sleep, poor sleep quality is associated in humans with an increased risk of developing metabolic syndrome, and in experimental animals with infectious diseases and changes in sexual motivation (Andersen et al, ; Knutson, Spiegel, Penev, & Van Cauter, ; Lungato et al, ; Ruiz, Andersen, Zager, Martins, & Tufik, ). The first two studies linking sleep deprivation to pregnancy loss were published by Pigareva () and by Calegare et al (), both in experimental animals.…”

Section: Discussionmentioning

confidence: 99%

Sleep deprivation decreases the reproductive capacity by affecting the arrival of morulas in the uterus

Calegare

Azzolini

Vallim

et al. 2019

Genesis

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Summary A previous animal study by our group found that sleep deprivation during preimplantation was associated with decreased pregnancy maintenance. Given its impact on human society, we aimed in the current study to assess whether sleep deprivation affects blastocyst gene expression and/or the implantation process. For this, pregnant mice (gestational day 0 [GD 0]) were assigned into paradoxical sleep deprivation (SD, 72 hr; multiple platform method) and, a control (CT) group. Animals were euthanized on GD 3.5 and blood, uterus (embryos) and fallopian tube were collected. Then, 89% of CT presented blastocysts in the uterus versus 25% from SD group. Compared to CT, SD presented lighter relative uterus weight, increased plasma concentrations of corticosterone and testosterone, decreased concentrations of progesterone and luteinizing hormone, but no statistical differences in plasma concentrations of 17β‐estradiol and follicle stimulating hormone. There were no differences in uterus and blastocyst gene expression related to embryo implantation and development, and no alteration in blastocysts global DNA methylation. Considering this, the decreased pregnancy maintenance after sleep deprivation seems not to be associated with implantation losses or developmental problems related to the blastocysts. It is likely that complications in morula development and/or its movement through the fallopian tubes affect the pregnancy rate, since only 25% of SD females presented a blastocyst on the GD 3.5. In fact, three out of four females without blastocysts in the uterus presented morula in the fallopian tubes due to a phase delay. Additionally, we suggest that the observed hormonal changes may play a role in this outcome.

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“…Epidemiological studies have shown that poor sleep increases susceptibility to diseases (1,5,40). Various biochemical studies have demonstrated that sleep loss can alter immune responses in both animals and humans (41)(42)(43). Leukocyte proliferation, humoral immunity, cell-mediated immunity, and immunoglobulin levels are reduced in participants with prolonged sleep disorders (44).…”

Section: Discussionmentioning

confidence: 99%

A proprietary black cumin oil extract (Nigella sativa) (BlaQmax®) modulates stress-sleep-immunity axis safely: Randomized double-blind placebo-controlled study

Mohan

Thomas²,

Mohan

et al. 2023

Front. Nutr.

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ObjectiveStress, sleep, and immunity are important interdependent factors that play critical roles in the maintenance of health. It has been established that stress can affect sleep, and the quality and duration of sleep significantly impact immunity. However, single drugs capable of targeting these factors are limited because of their multi-targeting mechanisms. The present study investigated the influence of a proprietary thymoquinone-rich black cumin oil extract (BCO-5) in modulating stress, sleep, and immunity.MethodsA randomized double-blinded placebo-controlled study was carried out on healthy volunteers with self-reported non-refreshing sleep issues (n = 72), followed by supplementation with BCO-5/placebo at 200 mg/day for 90 days. Validated questionnaires, PSQI and PSS, were employed for monitoring sleep and stress respectively, along with the measurement of cortisol and melatonin levels. Immunity markers were analyzed at the end of the study.ResultsIn the BCO-5 group, 70% of the participants reported satisfaction with their sleep pattern on day 7 and 79% on day 14. Additionally, both inter- and intra- group analyses of the total PSQI scores and component scores (sleep latency, duration, efficiency, quality, and daytime dysfunction) on days 45 and 90 showed the effectiveness of BCO-5 in the improvement of sleep (p < 0.05). PSS-14 analysis revealed a significant reduction in stress, upon both intra (p < 0.001) and inter-group (p < 0.001) comparisons. The observed reduction in stress among the BCO-5 group, with respect to the placebo, was significant with an effect size of 1.19 by the end of the study (p < 0.001). A significant correlation was also observed between improved sleep and reduced stress as evident from PSQI and PSS. Furthermore, there was a significant modulation in melatonin, cortisol, and orexin levels. Hematological/immunological parameters further revealed the immunomodulatory effects of BCO-5.ConclusionBCO-5 significantly modulated the stress-sleep-immunity axis with no side effects and restored restful sleep.

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Sleep deprivation reduces the lymphocyte count in a non-obese mouse model of type 1 diabetes mellitus

Cited by 31 publications

References 11 publications

Effect of the use of earplugs and eye mask on the quality of sleep in intensive care patients: a systematic review

Effect of the use of earplugs and eye mask on the quality of sleep in intensive care patients: a systematic review

Sleep deprivation decreases the reproductive capacity by affecting the arrival of morulas in the uterus

A proprietary black cumin oil extract (Nigella sativa) (BlaQmax®) modulates stress-sleep-immunity axis safely: Randomized double-blind placebo-controlled study

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