Sleep Deprivation Reveals Altered Brain Perfusion Patterns in Somnambulism

Dang‐Vu, Thien Thanh; Zadra, Antonio; Labelle, Marc-Antoine; Petit, Dominique; Soucy, Jean‐Paul; Montplaisir, J

doi:10.1371/journal.pone.0133474

Cited by 31 publications

(22 citation statements)

References 21 publications

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“…Interestingly, reduced brain perfusion in frontal and parietal regions persisted during resting-state wakefulness. These findings replicate the evidence from an earlier study [45], which hypothesised these areas to be responsible for the daytime impairment experienced in NREM parasomnia patients.…”

Section: Functional Imaging Studiessupporting

confidence: 90%

“…An overall reduction in brain metabolism when compared to wakefulness is the most striking characteristic [44]. This reduction is most obvious in brain regions responsible for a range motor and cognitive functions: brainstem, thalamus, basal ganglia, basal forebrain, prefrontal cortex, anterior cingulate cortex and precuneus [44,45]. As functional imaging studies have shown, there are some crucial differences in the characteristics of SWS in healthy controls and NREM parasomnia patients.…”

Section: Functional Imaging Studiesmentioning

confidence: 99%

“…Functional imaging studies have also shown that during an arousal parasomnia, local brain phenomena exhibit characteristics typical for both wakefulness and NREM sleep, simultaneously [45,46]. Single photon emission computed tomography (SPECT) was used to investigate brain activation during an episode of sleepwalking [46].…”

Section: Functional Imaging Studiesmentioning

confidence: 99%

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Adult NREM Parasomnias: An Update

2018

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Our understanding of non-rapid eye movement (NREM) parasomnias has improved considerably over the last two decades, with research that characterises and explores the causes of these disorders. However, our understanding is far from complete. The aim of this paper is to provide an updated review focusing on adult NREM parasomnias and highlighting new areas in NREM parasomnia research from the recent literature. We outline the prevalence, clinical characteristics, role of onset, pathophysiology, role of predisposing, priming and precipitating factors, diagnostic criteria, treatment options and medico-legal implications of adult NREM parasomnias.

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Section: Functional Imaging Studiessupporting

confidence: 90%

Section: Functional Imaging Studiesmentioning

confidence: 99%

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Adult NREM Parasomnias: An Update

2018

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“…Changes in associative visual areas during wakefulness might also predispose sleepwalkers to experience visual percepts during sleep. 74 …”

Section: 71mentioning

confidence: 99%

What Is the Link Between Hallucinations, Dreams, and Hypnagogic–Hypnopompic Experiences?

Waters

Blom²,

Dang‐Vu

et al. 2016

SCHBUL

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By definition, hallucinations occur only in the full waking state. Yet similarities to sleep-related experiences such as hypnagogic and hypnopompic hallucinations, dreams and parasomnias, have been noted since antiquity. These observations have prompted researchers to suggest a common aetiology for these phenomena based on the neurobiology of rapid eye movement (REM) sleep. With our recent understanding of hallucinations in different population groups and at the neurobiological, cognitive and interpersonal levels, it is now possible to draw comparisons between the 2 sets of experiences as never before. In the current article, we make detailed comparisons between sleep-related experiences and hallucinations in Parkinson's disease, schizophrenia and eye disease, at the levels of phenomenology (content, sensory modalities involved, perceptual attributes) and of brain function (brain activations, resting-state networks, neurotransmitter action). Findings show that sleep-related experiences share considerable overlap with hallucinations at the level of subjective descriptions and underlying brain mechanisms. Key differences remain however: (1) Sleep-related perceptions are immersive and largely cut off from reality, whereas hallucinations are discrete and overlaid on veridical perceptions; and (2) Sleep-related perceptions involve only a subset of neural networks implicated in hallucinations, reflecting perceptual signals processed in a functionally and cognitively closed-loop circuit. In summary, both phenomena are non-veridical perceptions that share some phenomenological and neural similarities, but insufficient evidence exists to fully support the notion that the majority of hallucinations depend on REM processes or REM intrusions into waking consciousness.

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“…Tc-ECD SPECT in order to investigate brain structures associated with somnambulism [29]. Ten sleepwalkers and 10 healthy controls were recruited and scanned after a night of sleep.…”

Section: Neuroimaging In Doamentioning

confidence: 99%

Disorders of Arousal

Galbiati

Manni

Terzaghi

et al. 2016

Curr Sleep Medicine Rep

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Sleepwalking, sleep terrors, and confusional arousals are non-REM sleep parasomnias grouped under the specific category of disorders of arousal (DOA). These conditions are characterized by incomplete arousals from deep sleep that lead to a broad variety of emotional and motor behaviors. The advent of electroencephalography (EEG) and the discovery of rapid eye movement (REM) sleep as opposed to non-REM sleep allowed researchers to consider these phenomena from a neurophysiological rather than a purely psychopathological perspective. The utilization of new neurophysiologic techniques such as high-density scalp EEG, stereo-EEG, and advanced signal analysis methods shed further light on the mechanisms underpinning DOA and supported the notion that they should be viewed within the frame of the so-called dissociate state of being as intermediate state between wake and NREM sleep. Furthermore, other important issues like the boundaries between motor-behavioral manifestations in DOA and NFLE, neurocognitive functions, the occurrence of mentation/dream imagery during episodes in DOA and DOA daytime consequences, and treatment are still matters of debate.

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Sleep Deprivation Reveals Altered Brain Perfusion Patterns in Somnambulism

Cited by 31 publications

References 21 publications

Adult NREM Parasomnias: An Update

Adult NREM Parasomnias: An Update

What Is the Link Between Hallucinations, Dreams, and Hypnagogic–Hypnopompic Experiences?

Disorders of Arousal

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