Sleep-disordered breathing and nocturnal oxygen desaturation in postmenopausal women

Block, A. Jay; Wynne, James W.; Boysen, Philip G.

doi:10.1016/0002-9343(80)90502-1

Cited by 169 publications

(73 citation statements)

References 10 publications

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“…In addition, we did not record the menopausal status of our women. Postmenopausal status is associated with an increased prevalence of sleep-disordered breathing (63,64), and circulating progesterone protects against dilation of the upper airway muscles (65). In our study, women were evenly distributed among age and compliance groups, which attenuated the effect of menopause on our results.…”

Section: Discussionmentioning

confidence: 99%

Effects of long-term continuous positive airway pressure on body composition and IGF1

Münzer

Hegglin

Stannek

et al. 2010

European Journal of Endocrinology

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Objective: To investigate the long-term effects of nasal continuous positive airway pressure (CPAP) ventilation in patients with obstructive sleep apnea syndrome (OSAS) on body composition (BC) and IGF1. Design: Observational study. Subjects: Seventy-eight (11 females and 67 males) OSAS patients who were compliant with CPAP (age 51G1.1 years) participated in the study. We assessed body mass index (BMI), total body mass (TBM), total body fat (TBF; kg) and lean body mass (LBM; kg), abdominal subcutaneous (SC) and visceral (V) fat (cm 2 ), and waist circumference (WC; cm) by magnetic resonance imaging, and IGF1 (ng/ml) before and after 7.8G1.3 months of CPAP use of an average of 5.9G1.2 h. Results: Women had a higher BMI, WC; TBM, TBF, and more SC fat. Men had a higher LBM and more V fat. CPAP increased WC (C2.8G9.6 cm, PZ0.02) and LBM (2.2G0.5 kg, PZ0.006), but not IGF1. In men, CPAP increased BMI (0.5G0.2 kg/m 2 , PZ0.02), WC (1.7G6.9 cm, PZ0.002), TBM (1.7G0.4 kg, PZ0.0001), LBM (1.5G0.4 kg, PZ0.0003), SC fat (12.9G5.1 cm 2 , PZ0.02), and IGF1 (13.6G4.2 ng/ml, PZ0.002). Compliance with CPAP increased LBM in men aged !60 years, but not in those aged O60 years, and IGF1 increased in men aged 40-60 years only. Conclusions: Long-term CPAP increased LBM in both sexes and IGF1 in men, while fat mass remained unchanged, suggesting a sexually dimorphic response of IGF1 to CPAP. The role of the GH axis activity and age to this response is unclear. The metabolic consequences of changes in LBM are still to be determined. Future studies on the effects of CPAP on BC should include LBM as an outcome.

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Section: Discussionmentioning

confidence: 99%

Effects of long-term continuous positive airway pressure on body composition and IGF1

Münzer

Hegglin

Stannek

et al. 2010

European Journal of Endocrinology

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“…In fact, no secretory activity of progesterone in such females was confirmed by other investigation (Vermeulen 1976). The findings that post-menopausal females might be suffered by abnormal breathing during sleep with the same incidences as in the males (Block et al 1980) would also support this inference. The effect of CMA was observed almost the same between males and post-menopausal females, that is, aP.2/P~oz in males and post-menopausal females before CMA were 0.50+0.35 and 0.41+0.06 cmH2O• mmHg 1, respectively, and load compensation ratio changed by CMA from 0.94+ 0.36 to 1.49±0.32, and from 0.99±0.32 to 1.32±0.10, respectively.…”

Section: Discussionmentioning

confidence: 64%

“…The effect of CMA was observed almost the same between males and post-menopausal females, that is, aP.2/P~oz in males and post-menopausal females before CMA were 0.50+0.35 and 0.41+0.06 cmH2O• mmHg 1, respectively, and load compensation ratio changed by CMA from 0.94+ 0.36 to 1.49±0.32, and from 0.99±0.32 to 1.32±0.10, respectively. The fact that post-menopausal females become more susceptible to disordered breathing during sleep (Block et al 1980), might suggest that progesterone has a protective action not to fall into hypoventilation.…”

Section: Discussionmentioning

confidence: 99%

Effect of chlormadinone acetate, a synthetic progesterone, on restoring impaired load compensation in chronic obstructive pulmonary disease.

Kimura

Tatsumi

Kuriyama

et al. 1986

Tohoku J. Exp. Med.

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“…A korai tanulmányok alapján a klinikusok sokáig úgy gondolták, hogy az OSA csak a posztmenopauzában lévő nők körében jelenik meg, és a premenopauzában lévő nők védve vannak a női hormonok által [30,31]. A női nemi hormonok szerepe a felső légutak fi ziológiás szabályozásában még nem ismert pontosan.…”

Section: öSszefoglaló Közleményunclassified

Obstructive sleep apnea in women

et al. 2014

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A különböző alvászavarok prevalenciája és klinikai-tüneti megnyilvánulása eltérő lehet a férfi ak és a nők körében. Az utóbbi évek kutatásai hívták fel a fi gyelmet az obstruktív alvási apnoe gyakori előfordulására nők körében is, mivel a férfi akkal ellentétben, főként az atípusos tünetek miatt (mint a reggeli fejfájás, depresszióra jellemző tünetek, nappali fáradtság) az esetek nagy részében nem diagnosztizálják ezt a betegséget. Mindkét nemnél nagy jelentősége van az alvászavarok korai felismerésének és kezelésének, az életminőség, társbetegségek és a mortalitás szempontjából. Orv. Hetil., 2014, 155(52), 2067-2073 Kulcsszavak: obstruktív alvási apnoe, nemek közötti különbség, életminőség, depresszió Obstructive sleep apnea in womenThe prevalence of sleep disturbances and their symptomatic manifestations may be different in men and women. Women with obstructive sleep apnea are less likely to be diagnosed with sleep apnea compared to men, probably due to atypical symptoms such as morning headaches, symptoms of depression and daytime fatigue. There is a great importance of diagnosis and treatment of sleep disorders regarding quality of life, co-morbidity and mortality in both genders. Keywords ÖSSZEFOGLALÓ KÖZLEMÉNYRövidítések AHI = (apnea-hypopnea index) apnoe-hypopnoe index; CPAP = (continous positive airway pressure) folyamatos pozitív nyomású légzéstámogatás; ESS = (Epworth Sleepiness Scale) Epworth Álmossági Skála; MBS = (metabolic syndrome) metabolikus szindróma; OSA = (obstructive sleep apnea) obstruktív alvási apnoe; OSAS = (obstructive sleep apnea syndrome) obstruktív alvási apnoe szindróma Az elmúlt néhány évtizedben egyre nagyobb fi gyelem övezi az alvászavarok problémakörét, és a kutatások egy része a nemek közti különbségeket elemzi. A nők és a férfi ak körében bár ugyanazon alvás-és ébrenléti zavarok fordulnak elő, ezek megnyilvánulásai, tünetei, egészség-ügyi következményei, kihatásai a mindennapi életre elté-rő módon és mértékben jelentkeznek. Jelen tanulmá-nyunkban az alvási apnoét tekintjük át. Defi nícióAz obstruktív alvási apnoe (OSA) az alvás alatti légzésza-varok leggyakoribb formája. Jellemző rá a felső légutak alvás alatti ismétlődő, részleges vagy teljes elzáródása, ami azt eredményezi, hogy az egyre fokozódó belégzési erőfeszítés (effort) ellenére hypopnoe, illetve apnoe alakul ki [1]. Hypopnoénak nevezzük a légutak részleges

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Sleep-disordered breathing and nocturnal oxygen desaturation in postmenopausal women

Cited by 169 publications

References 10 publications

Effects of long-term continuous positive airway pressure on body composition and IGF1

Effects of long-term continuous positive airway pressure on body composition and IGF1

Effect of chlormadinone acetate, a synthetic progesterone, on restoring impaired load compensation in chronic obstructive pulmonary disease.

Obstructive sleep apnea in women

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