Sleep disordered breathing in patients with cluster headache

Lüdemann, Peter; Frese, A.; Happe, Svenja; Evers, Stefan; Chervin, Ronald D.; Zallek, Sarah Nath

doi:10.1212/wnl.56.7.984

Cited by 20 publications

(16 citation statements)

References 8 publications

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“…4 There have also been some additional case reports that treating the apnea with continuous positive airway pressure prevents CH. [5][6][7][8] These reports support the hypothesis that the decrease in blood oxygen saturation from SDB may be the trigger for these nighttime CH. Nobre et al reported a lower association with only 31.3% (5/16) of the patients with an episodic cluster having apnea.…”

supporting

confidence: 56%

“…This was confirmed by Chervin who recruited patients with CH and reported that 80% had an apnea hypopnea index (AHI) > 5 4 . There have also been some additional case reports that treating the apnea with continuous positive airway pressure prevents CH 5–8 . These reports support the hypothesis that the decrease in blood oxygen saturation from SDB may be the trigger for these nighttime CH.…”

mentioning

confidence: 69%

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Obstructive Sleep Apnea and Cluster Headache

Graff‐Radford

Newman²

2004

Headache

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The data closely approximate those of Chervin et al, where 80% had RDI > 5. The relationship sleep apnea has in the perpetuation or precipitation of cluster headache is still to be determined. There are some reports that treatment stops the cluster but there is no prospective study. The high incidence (80.64%) seen in this population suggests the cluster patient should receive a sleep evaluation and perhaps intervention with continuous positive airway pressure (CPAP) or an appropriate dental device.

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supporting

confidence: 56%

mentioning

confidence: 69%

Obstructive Sleep Apnea and Cluster Headache

Graff‐Radford

Newman²

2004

Headache

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show abstract

“…Several characteristic features of obstructive sleep apnea, including hypoxemia, hypercapnia, and abrupt changes in sympathetic tone, could trigger some of the vascular changes that are thought to occur during cluster headaches. Researchers have found an independent association between the extent of hypoxemia and the timing of cluster headaches in the first half of the night (close to the onset of sleep and obstructive sleep apnea, possibly with a refractory period during the second half of the night) [36]. Therefore, it has been speculated by Kudrow et al [30] and Nath Zallek and Chervin [35••] that hypoxemia may be a key trigger of cluster headaches [37].…”

Section: Obstructive Sleep Apneamentioning

confidence: 99%

Cluster headaches and sleep disorders

Weintraub

2003

Current Science Inc

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Cluster headaches are characterized by unilateral paroxysmal attacks of severe pain with associated symptoms. The headaches occur during particular sleep stages and are associated with other chronobiologic factors. Several sleep disorders have been associated with the occurrence of cluster headache; multiple hormonal influences affect the relationship between sleep and headache. Melatonin and other treatments that affect circadian rhythm have been suggested for the treatment of cluster headache. Obstructive sleep apnea can occur in patients with cluster headache; attempts to treat one disorder may influence the other. Sleep disorders such as insomnia and narcolepsy also may be associated with and influence cluster headaches. This article examines the relationship between the various sleep disorders and cluster headache, and reviews current research. Normal and abnormal sleep and details of treatments for specific sleep disorders that may decrease the frequency and severity of cluster headaches also are discussed. The relationship between obstructive sleep apnea, which is the most common sleep disorder, and cluster headache is discussed in detail.

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“…Two facts support this hypothesis: 1) oxygen administration is effi cient in aborting CH attacks and 2) provoked hypoxic states trigger CHs [29][30][31][32]. Furthermore, few case reports show that treating the apnea with CPAP may prevent the development of CHs [33,34]. These reports further support the idea that CH may be triggered by the decrease in blood oxygen saturation from sleep-disordered breathing (SDB), particularly in patients whose CHs happen at night.…”

Section: Discussionmentioning

confidence: 85%

Cluster headache and obstructive sleep apnea: Are they related disorders?

Graff‐Radford

Teruel²

2009

Current Science Inc

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Patients with cluster headache (CH) have a higher prevalence of sleep apnea, and a possible relationship between these two conditions has been proposed. Although patients suffering from CH attacks often wake up from sleep, sleep apnea has been suggested to be a trigger or an associated abnormality in CH. It has been proposed that regulation of the hypothalamus may be responsible for sleep apnea, and that similiarly CH is generated in the hypothalamus. However, there is evidence that CH and obstructive sleep apnea are not causal, but rather parallel processes both generated in the hypothalamus. The exact role that sleep apnea plays in the perpetuation or precipitation of CH is still to be determined. This paper discusses the proposed pathophysiological mechanisms of these two entities and the possible relationship between CH and sleep apnea.

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Sleep disordered breathing in patients with cluster headache

Cited by 20 publications

References 8 publications

Obstructive Sleep Apnea and Cluster Headache

Obstructive Sleep Apnea and Cluster Headache

Cluster headaches and sleep disorders

Cluster headache and obstructive sleep apnea: Are they related disorders?

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