Sleep Disorders and Cognitive Dysfunctions in Parkinson’s Disease: A Meta-Analytic Study

Maggi, Gianpaolo; Trojano, Luigi; Barone, Paolo; Santangelo, Gabriella

doi:10.1007/s11065-020-09473-1

Cited by 48 publications

(42 citation statements)

References 159 publications

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“…However, treatment with cholinesterase inhibitors seems to delay the conversion although not affecting the natural history of disease; lifestyle modifications including diet, aerobic exercise, and cognitive stimulation may decrease the risk of conversion [130]. Clinicians should consider anxiety [131,132], apathy [133][134][135], diabetes [136], sleep [137,138] and cardiovascular disorders [139] as other factors increasing the risk of conversion and negative outcomes.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychology of posteromedial parietal cortex and conversion factors from Mild Cognitive Impairment to Alzheimer’s disease: systematic search and state-of-the-art review

et al. 2021

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In the present review, we discuss the rationale and the clinical implications of assessing visuospatial working memory (VSWM), awareness of memory deficits, and visuomotor control in patients with mild cognitive impairment (MCI). These three domains are related to neural activity in the posteromedial parietal cortex (PMC) whose hypoactivation seems to be a significant predictor of conversion from MCI to Alzheimer’s disease (AD) as indicated by recent neuroimaging evidence. A systematic literature search was performed up to May 2021. Forty-eight studies were included: 42 studies provided analytical cross-sectional data and 6 studies longitudinal data on conversion rates. Overall, these studies showed that patients with MCI performed worse than healthy controls in tasks assessing VSWM, awareness of memory deficits, and visuomotor control; in some cases, MCI patients’ performance was comparable to that of patients with overt dementia. Deficits in VSWM and metamemory appear to be significant predictors of conversion. No study explored the relationship between visuomotor control and conversion. Nevertheless, it has been speculated that the assessment of visuomotor abilities in subjects at high AD risk might be useful to discriminate patients who are likely to convert from those who are not. Being able to indirectly estimate PMC functioning through quick and easy neuropsychological tasks in outpatient settings may improve diagnostic and prognostic accuracy, and therefore, the quality of the MCI patient’s management.

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Section: Discussionmentioning

confidence: 99%

Neuropsychology of posteromedial parietal cortex and conversion factors from Mild Cognitive Impairment to Alzheimer’s disease: systematic search and state-of-the-art review

et al. 2021

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“…Studies investigating the relationship between sleep disturbances and neuropsychological functions, conducted mainly in early to moderate PD patients, support the notion that some sleep alterations like RBD and EDS are connected to the development of cognitive dysfunctions and dementia in PD patients [5][6][7][8][9][10]12].…”

Section: Introductionmentioning

confidence: 91%

“…Sleep problems are known to contribute to neuropsychological deficits in otherwise healthy people [1]. The association between sleep problems and cognitive disorders has been explored in neurodegenerative disease, such as Alzheimer's disease (AD) [2][3][4] and PD [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Association between sleep disorders and cognitive dysfunctions in non-demented patients with advanced Parkinson’s disease

et al. 2021

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Background Parkinson’s disease (PD) is increasingly recognized as a multidimensional disorder, characterized by several non-motor symptoms, including disturbances of sleep and cognition. Current studies on the relationship between sleep problems and neuropsychological functions, mainly conducted in early to moderate PD patients, outline mixed results. In this study, we analysed the relationship between subjectively reported sleep alterations and cognitive functions in a large cohort of 181 advanced PD patients. Methods All consecutive, non-demented, advanced PD patients candidates for device-aided therapy completed two self-administered sleep questionnaires—the Parkinson’s Disease Sleep Scale (PDSS-2) and the Epworth Sleepiness Scale (ESS)—and underwent a comprehensive battery of neuropsychological tests encompassing five cognitive domains (reasoning, memory, attention, frontal executive functions, and language). Results Patients showed mild to moderate sleep problems (PDSS-2 score: 23.4 ± 1.2) and mild daytime sleepiness (ESS 8.6 ± 5.1). A significant correlation was found between PDSS-2 total score and non-verbal reasoning, as well as attentive skills, executive functions, and language abilities. No correlations were found between sleep measures and memory tests scores. Patients with clinically relevant sleep disturbances performed worse on attention, executive functions, and language. No significant correlations were found between daytime sleepiness and any neuropsychological test. Conclusions In advanced PD patients, sleep disturbances selectively correlate with specific neuropsychological functions and not with short-term memory and consolidation. Even if confirmations by means of longitudinal studies are needed, our observations suggest the importance of considering treatment of sleep disturbances to minimize their potential impact on cognition.

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“…RBD can be evidenced in the early stages of a progressive neurodegenerative disease involving alpha-synuclein pathology and could be used as a biomarker for the prediction of PDD [29]. RBD reflects abnormalities of frontal networks and posterior cortical areas and in general sleep disorders in patients with PD appear to increase the risk for long-term cognitive decline [30]. Moreover, olfaction deficits are a common non-motor symptom in PDD.…”

Section: Epidemiology Clinical Characteristics Timing and Neurobiolog...mentioning

confidence: 99%

Parkinsonism and dementia

Koros

Stefanis

Scarmeas

2022

Journal of the Neurological Sciences

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Sleep Disorders and Cognitive Dysfunctions in Parkinson’s Disease: A Meta-Analytic Study

Cited by 48 publications

References 159 publications

Neuropsychology of posteromedial parietal cortex and conversion factors from Mild Cognitive Impairment to Alzheimer’s disease: systematic search and state-of-the-art review

Neuropsychology of posteromedial parietal cortex and conversion factors from Mild Cognitive Impairment to Alzheimer’s disease: systematic search and state-of-the-art review

Association between sleep disorders and cognitive dysfunctions in non-demented patients with advanced Parkinson’s disease

Parkinsonism and dementia

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