Sleep disorders and health-related quality of life in patients with interstitial lung disease

Mavroudi, Maria; Papakosta, Despoina; Kontakiotis, Theodoros; Domvri, Kaliopi; Kalamaras, George; Zarogoulidou, Vasiliki; Latka, Paschalina; Huang, Haidong; Hohenforst-Schmidt, Wolfgang; Zarogoulidis, Konstantinos

doi:10.1007/s11325-017-1579-1

Cited by 40 publications

(26 citation statements)

References 24 publications

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“…HRQoL was measured at baseline using the Short Form Health Survey (SF-36). The aim of SF-36 is to characterize and understand the relationship between the selected baseline clinical covariates, the physical component score (PCS), and the mental component score (MCS) [25]. This questionnaire is a validated instrument for assessing HRQoL and has been applied to a variety of chronic medical conditions, including IPF [7].…”

Section: Data Collectionmentioning

confidence: 99%

Clinical and Functional Characteristics of Patients with Unclassifiable Interstitial Lung Disease (uILD): Long-Term Follow-Up Data from European IPF Registry (eurIPFreg)

Krauss

El-Guelai

Pons-Kuehnemann

et al. 2020

JCM

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: (1) Aim of the study: In spite of extensive research, up to 20% of interstitial lung diseases (ILD) patients cannot be safely classified. We analyzed clinical features, progression factors, and outcomes of unclassifiable ILD (uILD). (2) Methods: A total of 140 uILD subjects from the University of Giessen and Marburg Lung Center (UGMLC) were recruited between 11/2009 and 01/2019 into the European Registry for idiopathic pulmonary fibrosis (eurIPFreg) and followed until 01/2020. The diagnosis of uILD was applied only when a conclusive diagnosis could not be reached with certainty. (3) Results: In 46.4% of the patients, the uILD diagnosis was due to conflicting clinical, radiological, and pathological data. By applying the diagnostic criteria of usual interstitial pneumonia (UIP) based on computed tomography (CT), published by the Fleischner Society, 22.2% of the patients displayed a typical UIP pattern. We also showed that forced vital capacity (FVC) at baseline (p = 0.008), annual FVC decline ≥10% (p < 0.0001), smoking (p = 0.033), and a diffusing capacity of the lung for carbon monoxide (DLco) ≤55% of predicted value at baseline (p < 0.0001) were significantly associated with progressive disease. (4) Conclusions: The most important prognostic factors in uILD are baseline level and decline in lung function and smoking. The use of Fleischner diagnostic criteria allows further differentiation and accurate diagnosis.

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Section: Data Collectionmentioning

confidence: 99%

Clinical and Functional Characteristics of Patients with Unclassifiable Interstitial Lung Disease (uILD): Long-Term Follow-Up Data from European IPF Registry (eurIPFreg)

Krauss

El-Guelai

Pons-Kuehnemann

et al. 2020

JCM

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“…light/dark cycles, eating/fasting activity) [ 2 ]. However, the temporal entrainment by the environment enables the physiological processes to be optimized with respect to daily changes and improves survival [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Daily variation of gene expression in diverse rat tissues

et al. 2018

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Circadian information is maintained in mammalian tissues by a cell-autonomous network of transcriptional feedback loops that have evolved to optimally regulate tissue-specific functions. An analysis of daily gene expression in different tissues, as well as an evaluation of inter-tissue circadian variability, is crucial for a systems-level understanding of this transcriptional circuitry. Affymetrix gene chip measurements of liver, muscle, adipose, and lung tissues were obtained from a rich time series light/dark experiment, involving 54 normal rats sacrificed at 18 time points within the 24-hr cycle. Our analysis revealed a high degree of circadian regulation with a variable distribution of phases among the four tissues. Interestingly, only a small number of common genes maintain circadian activity in all tissues, with many of them consisting of “core-clock” components with synchronous rhythms. Our results suggest that inter-tissue circadian variability is a critical component of homeostatic body function and is mediated by diverse signaling pathways that ultimately lead to highly tissue-specific transcription regulation.

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“…Interestingly, c-PAP therapy led to a normalization of eNO parameters, suggesting its potential role as a biomarker of compliance and response to therapy [ 97 , 98 ]. Although a significant percentage of ILD patients suffer from OSA [ 99 , 100 ], no data are currently available about eNO parameters in this setting. Despite lack of evidence, a significant influence of OSA on eNO parameters is likely and, therefore, quality of sleep should be assessed in ILD patients, considering also its negative prognostic impact [ 101 ].…”

Section: Comorbidities/complications Of Ilds: a Pitfall For Eno Anmentioning

confidence: 99%

Extended Exhaled Nitric Oxide Analysis in Interstitial Lung Diseases: A Systematic Review

Cameli

Bargagli

Bergantini

et al. 2020

IJMS

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Fractional exhaled nitric oxide (FeNO) is a well-known and widely accepted biomarker of airways inflammation that can be useful in the therapeutic management, and adherence to inhalation therapy control, in asthmatic patients. However, the multiple-flows assessment of FeNO can provide a reliable measurement of bronchial and alveolar production of NO, supporting its potential value as biomarker also in peripheral lung diseases, such as interstitial lung diseases (ILD). In this review, we first discuss the role of NO in the pathobiology of lung fibrosis and the technique currently approved for the measurement of maximum bronchial flux of NO (J’awNO) and alveolar concentration of NO (CaNO). We systematically report the published evidence regarding extended FeNO analysis in the management of patients with different ILDs, focusing on its potential role in differential diagnosis, prognostic evaluation and severity assessment of disease. The few available data concerning extended FeNO analysis, and the most common comorbidities of ILD, are explored too. In conclusion, multiple-flows FeNO analysis, and CaNO in particular, appears to be a promising tool to be implemented in the diagnostic and prognostic pathways of patients affected with ILDs.

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Sleep disorders and health-related quality of life in patients with interstitial lung disease

Abstract: In this sample of patients with IPF and sarcoidosis, obstructive sleep apnea is common at least in a mild degree of severity. The SF-36 questionnaire may be a useful tool for the evaluation of the quality of life in these patients.

Cited by 40 publications

References 24 publications

Clinical and Functional Characteristics of Patients with Unclassifiable Interstitial Lung Disease (uILD): Long-Term Follow-Up Data from European IPF Registry (eurIPFreg)

Clinical and Functional Characteristics of Patients with Unclassifiable Interstitial Lung Disease (uILD): Long-Term Follow-Up Data from European IPF Registry (eurIPFreg)

Daily variation of gene expression in diverse rat tissues

Extended Exhaled Nitric Oxide Analysis in Interstitial Lung Diseases: A Systematic Review

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