Sleep Disorders and Increased Risk of Autoimmune Diseases in Individuals without Sleep Apnea

Hsiao, Yi-Han; Chen, Yung Tai; Tseng, Ching Min; Wu, Li Hua; Lin, Wei Chen; Su, Vin‐Cent; Perng, Diahn Warng; Chang, Shi Chuan; Chen, Yuh Min; Chen, Tzeng Ji; Lee, Yu Chin; Chou, Kun-Ta

doi:10.5665/sleep.4574

Cited by 83 publications

(71 citation statements)

References 21 publications

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“…The demographic characteristics for all sampled participants are shown in Table , including 91 273 NSD patients and 91 273 controls. NSD included 45.58% of insomnia (ICD‐9‐CM codes: 780.52, 307.41, 307.42), 46.81% of sleep disturbance (ICD‐9 CM codes: 780.5, 780.50) and 7.62% of other disorders related to the sleep–wake schedule and parasomnias (ICD‐9 CM codes: 780.55, 780.56, 780.59 and 307.4) (Hsiao et al ., ). The controls were matched for age, gender, income, urbanization level and the CCI score (all P > 0.9).…”

Section: Resultsmentioning

confidence: 97%

Sleep disorders and an increased risk of Parkinson's disease in individuals with non‐apnea sleep disorders: a population‐based cohort study

Hsiao

Chen

Tseng

et al. 2017

Journal of Sleep Research

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Sleep disorders are common non-motor symptoms in patients with Parkinson's disease. Our study aims to explore the relationship between non-apnea sleep disorders and future Parkinson's disease. This is a cohort study using a nationwide database. The participants were recruited from the Taiwan National Health Insurance Research Database between 2000 and 2003. A total of 91 273 adult patients who had non-apnea sleep disorders without pre-existing Parkinson's disease were enrolled. An age-, gender-, income-, urbanization- and Charlson comorbidity index score-matched control cohort consisting of 91 273 participants was selected for comparison. The two cohorts were followed for the occurrence of Parkinson's disease, death or until the end of 2010, whichever came first. The Kaplan-Meier analyses revealed patients with non-apnea sleep disorders tended to develop Parkinson's disease (log-rank test, P < 0.001). After a multivariate adjustment in a Cox regression model, non-apnea sleep disorders was an independent risk factor for the development of Parkinson's disease [crude hazard ratio: 1.63, 95% confidence interval (CI): 1.54-1.73, P < 0.001; adjusted hazard ratio: 1.18, 95% CI: 1.11-1.26, P < 0.001]. In the subgroup analysis, patients with chronic insomnia (lasting more than 3 months) had the greatest risk (crude hazard ratio: 2.91, 95% CI: 2.59-3.26, P < 0.001; adjusted hazard ratio: 1.37, 95% CI: 1.21-1.55, P < 0.001). In conclusion, this study revealed that non-apnea sleep disorders, especially chronic insomnia, are associated with a higher risk for future Parkinson's disease.

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Section: Resultsmentioning

confidence: 97%

Sleep disorders and an increased risk of Parkinson's disease in individuals with non‐apnea sleep disorders: a population‐based cohort study

Hsiao

Chen

Tseng

et al. 2017

Journal of Sleep Research

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“…The presence of abnormal sleep for patients with Crohn's disease in remission at baseline has been linked with 2× increased risk of disease flare within the subsequent 6 months [ 14 ]. Two separate longitudinal studies found that individuals with sleep disorder [ 73 ] and patients with obstructive sleep apnoea [ 74 ] were at a higher risk for developing autoimmune diseases (including ankylosing spondylitis). It is therefore possible that regular screening for disturbed sleep could be useful in assessing disease activity and predicting future flares.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and factors associated with disturbed sleep in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a systematic review

et al. 2016

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“…Sleep has a strong regulatory influence on immune functions. The disturbance of the body's immunity caused by sleep deprivation is not limited to the suppression of the response to pathogens; it can also result in the collapse of immunological self-tolerance, which can cause the onset of autoimmune disease [1][2][3]. Cross-sectional studies have shown that sleep disorders in individuals with autoimmune diseases are correlated with pain, fatigue, psychiatric manifestations, and disease activity [4].…”

Section: Introductionmentioning

confidence: 99%

The prevalence of insomnia and restless legs syndrome among Japanese outpatients with rheumatic disease: A cross-sectional study

et al. 2020

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The prevalence of symptomatic insomnia and the prevalence of restless legs syndrome (RLS) are known to be higher among patients with rheumatic diseases compared to the general population. The prevalences of insomnia and RLS reported in a questionnaire by Japanese patients with rheumatic diseases at an outpatient clinic were analyzed herein. The association between the patients' disease activity and their sleep quality was analyzed. Of 121 rheumatic disease patients, 70 were enrolled. The median (interquartile range) age at enrollment was 62.0 (47.8-68.0) years. There were 58 women (82.9%) and 12 men (17.1%), and 43 patients (61.4%) with rheumatoid arthritis (RA), nine (12.9%) with systemic lupus erythematosus (SLE), and 18 (25.7%) with other rheumatic diseases. Twenty patients (28.6%) had one or more moderate-to-severe insomnia symptoms, and 10 (14.3%) were diagnosed with RLS. Among the patients with RA, the swollen joint count based on a 28joint assessment (SJC28) was significantly higher in the insomnia group (n = 13) compared to the non-insomnia group (n = 30) (p = 0.006). A classification and regression tree (CART) analysis showed that the cutoff points of �3 mg/day prednisolone (PSL) treatment and <16.54% as the transferrin saturation (TSAT) value would best predict RLS in rheumatic disease. Patients with rheumatic disease had a high prevalence of symptomatic insomnia and RLS. A higher dose of PSL and lower TSAT were associated with the occurrence of RLS.

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Sleep Disorders and Increased Risk of Autoimmune Diseases in Individuals without Sleep Apnea

Abstract: Patients with non-apnea sleep disorder were associated with a higher risk for developing autoimmune diseases.

Cited by 83 publications

References 21 publications

Sleep disorders and an increased risk of Parkinson's disease in individuals with non‐apnea sleep disorders: a population‐based cohort study

Sleep disorders and an increased risk of Parkinson's disease in individuals with non‐apnea sleep disorders: a population‐based cohort study

Prevalence and factors associated with disturbed sleep in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a systematic review

The prevalence of insomnia and restless legs syndrome among Japanese outpatients with rheumatic disease: A cross-sectional study

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