Sleep Disorders in Acute Stroke

Kojic, Biljana; Dostović, Zikrija; Vidović, Mirjana; Ibrahimagić, Omer Ć.; Hodžić, Renata; Iljazović, Amra

doi:10.5455/msm.2022.33.14-18

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one study of ischemic stroke patients, 56.7% reported sleep complaints, and 37.5% met the DSM-IV criteria for insomnia [ 40 ]. However, in other studies, the stroke population was of a different duration; they were either acute [ 41 ] or chronic [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Mediating Role of Sleep Deficit-Related Functional Status in Subacute Stroke Survivors

Kumar,

Parveen,

Manzar

et al. 2024

Medicina

View full text Add to dashboard Cite

Background: Understanding post-stroke fatigue (PSF) and its associated factors is crucial for effective therapy and rehabilitation. This study aimed to assess the mediating role of the excessive daytime sleepiness-related functional status (SFS) on the relationship between sleep and the severity of fatigue in subacute stroke survivors. Methods: Subacute stroke survivors (n = 50; male = 38; female = 12), completed a cross-sectional study involving the Pittsburgh sleep quality index (PSQI), the Epworth sleepiness scale (ESS), the insomnia severity index (ISI), the functional outcome of the sleep questionnaire (FOSQ), and the fatigue severity scale (FSS). Results: The SFS mediated the association between the severity of fatigue and sleep problems. The PSQI and FOSQ (b = −0.37, p < 0.001), and the FOSQ and FSS were correlated (b = −0.18, p < 0.05), with a significant indirect effect of the PSQI on the FSS. The ISI correlated with the FOSQ (b = −0.20, p < 0.001), with significant direct (b = 0.15, p < 0.001), as well as indirect, effects of the ISI on the FSS. The ESS correlated with the FOSQ (b = −0.23, p < 0.001), with a significant indirect effect of the ESS on the FSS. Conclusions: In subacute stroke survivors, fatigue and sleep are linked. Increased understanding of sleep-PSF may help in exploring new targets for supplement therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring the Mediating Role of Sleep Deficit-Related Functional Status in Subacute Stroke Survivors

Kumar,

Parveen,

Manzar

et al. 2024

Medicina

View full text Add to dashboard Cite

show abstract

“…A large body of clinical data shows that sleep disorders are highly prevalent among stroke survivors; more than half of stroke victims have trouble sleeping in the months following. Severe abnormalities in the quantity and quality of sleep or circadian rhythm disorders occur during the hyper‐acute phase 7–15 . Observational studies have shown that poor sleep quality is associated with poor functional status, which has a detrimental effect on stroke course and outcome 16,17 .…”

Section: Introductionmentioning

confidence: 99%

“…Severe abnormalities in the quantity and quality of sleep or circadian rhythm disorders occur during the hyper‐acute phase. 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 Observational studies have shown that poor sleep quality is associated with poor functional status, which has a detrimental effect on stroke course and outcome. 16 , 17 Therefore, in the absence of effective means to promote stroke recovery, active interventions to improve sleep may be a promising strategy to enhance functional recovery after stroke.…”

Section: Introductionmentioning

confidence: 99%

Alleviating sleep disturbances and modulating neuronal activity after ischemia: Evidence for the benefits of zolpidem in stroke recovery

Zhong,

Tao,

Hao

et al. 2024

CNS Neurosci Ther

View full text Add to dashboard Cite

AimsSleep disorders are prevalent among stroke survivors and impede stroke recovery, yet they are still insufficiently considered in the management of stroke patients, and the mechanisms by which they occur remain unclear. There is evidence that boosting phasic GABA signaling with zolpidem during the repair phase improves stroke recovery by enhancing neural plasticity; however, as a non‐benzodiazepine hypnotic, the effects of zolpidem on post‐stroke sleep disorders remain unclear.MethodTransient ischemic stroke in male rats was induced with a 30‐minute middle cerebral artery occlusion. Zolpidem or vehicle was intraperitoneally delivered once daily from 2 to 7 days after the stroke, and the electroencephalogram and electromyogram were recorded simultaneously. At 24 h after ischemia, c‐Fos immunostaining was used to assess the effect of transient ischemic stroke and acute zolpidem treatment on neuronal activity.ResultsIn addition to the effects on reducing brain damage and mitigating behavioral deficits, repeated zolpidem treatment during the subacute phase of stroke quickly ameliorated circadian rhythm disruption, alleviated sleep fragmentation, and increased sleep depth in ischemic rats. Immunohistochemical staining showed that in contrast to robust activation in para‐infarct and some remote areas by 24 h after the onset of focal ischemia, the activity of the ipsilateral suprachiasmatic nucleus, the biological rhythm center, was strongly suppressed. A single dose of zolpidem significantly upregulated c‐Fos expression in the ipsilateral suprachiasmatic nucleus to levels comparable to the contralateral side.ConclusionStroke leads to suprachiasmatic nucleus dysfunction. Zolpidem restores suprachiasmatic nucleus activity and effectively alleviates post‐stroke sleep disturbances, indicating its potential to promote stroke recovery.

show abstract

Development and validation of a nomogram for sleep disorders among stroke patients

Fan,

Yang,

Sun

et al. 2024

Clinical Neurology and Neurosurgery

View full text Add to dashboard Cite

Sleep Disorders in Acute Stroke

Cited by 3 publications

References 0 publications

Exploring the Mediating Role of Sleep Deficit-Related Functional Status in Subacute Stroke Survivors

Exploring the Mediating Role of Sleep Deficit-Related Functional Status in Subacute Stroke Survivors

Alleviating sleep disturbances and modulating neuronal activity after ischemia: Evidence for the benefits of zolpidem in stroke recovery

Development and validation of a nomogram for sleep disorders among stroke patients

Contact Info

Product

Resources

About