Sleep disturbance in mild to moderate Alzheimer's disease

Morán, María Teresa Cabero; Lynch, Cecelia A.; Walsh, Cathal; Coen, Robert F.; Coakley, Davis; Lawlor, Brian A.

doi:10.1016/j.sleep.2004.12.005

Cited by 297 publications

(212 citation statements)

References 36 publications

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“…Another study showed that, prevalence of sleep disturbance was 24.5% among mild to moderate Alzheimer's disease associated with other behavioral disturbances. 11 It was not consistent with this study. Researcher found that demented patients usually slept at daytime, due to forgetfulness they usually failed to remember when they usually sleep.…”

Section: Resultscontrasting

confidence: 67%

Common behavioral problems among patients with dementia attending in tertiary care hospitals in Dhaka city

Tarannum¹,

Sultana²,

Algin

et al. 2017

Bang J Psychiatry

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Elderly people are increasing day by day both in developing and developed country due to development of new treatment, increased awareness of people and improved health facilities. This present study was conducted with the aim to identify behavioral problems according to severity of dementia. This descriptive cross sectional study was conducted in the Department of Psychiatry and Department of Neuro-medicine of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh and in National Institute of Mental Health (NIMH), Sher-E-Bangla Nagar, Dhaka, Bangladesh from September 2013 to March 2015. A total 150 patients were selected purposefully; severity of dementia was graded according to Mini Mental State Examination (MMSE) and another questionnaire was applied to detect behavioral problems of patients. In this study mild dementia was found as the most frequent (38%), followed by severe dementia (35.3%) and moderate dementia (26.7%). The results indicated that behavioral problem was more common in severe dementia. Behavioral problem was more common in severe dementia than in mild and moderate dementia. Among behavioral problems sleep disturbance and sexual disturbance were statistically significant This study provides information about pattern of behavioral problems among patients with dementia. Liaison approach with other discipline may improve quality of life of these patients treatable.

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Section: Resultscontrasting

confidence: 67%

Common behavioral problems among patients with dementia attending in tertiary care hospitals in Dhaka city

Tarannum¹,

Sultana²,

Algin

et al. 2017

Bang J Psychiatry

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“…Our research has shown that having to cope with frequent nocturnal awakenings is far more distressing for caregivers than having a family member who gets up too early in the morning, (26) perhaps because in the latter case, caregivers can cope by adapting their sleep-wake schedule to that of the care-recipient. (6) Similarly, caregivers might react quite differently to nighttime wakefulness in a calmly confused individual who naps too much during the day, as opposed to someone with severe psychiatric symptoms such as physical aggression or hallucinations, (26,27) which are themselves risk factors for caregiver burden and institutional placement.…”

Section: Sleep and Caregiver Burdenmentioning

confidence: 99%

Sleep disturbances in caregivers of persons with dementia: Contributing factors and treatment implications

McCurry

Logsdon

Teri

et al. 2007

Sleep Medicine Reviews

259

263

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Estimates suggest that there are more than 10 million adult caregivers of persons with dementia, twothirds of who experience some form of sleep disturbance during the course of their caregiving career. Health care professionals are in the best position to detect and address this significant public health problem. Three major contributors to caregiver sleep disturbance are discussed in this paper: 1) the presence of caregiver disrupted sleep routines; 2) caregiver burden and depression; and, 3) the caregiver's physical health status. Successful treatment of a caregiver's sleep disturbance requires careful consideration of each of these contributors. We review and analyze the scientific literature concerning the multiple complex factors associated with the development and maintenance of sleep disturbances in caregivers. We provide a clinical vignette that illustrates the interplay of these contributing factors, and close by providing recommendations for clinicians and researchers treating and investigating the development and maintenance of sleep problems in family caregivers. Keywordssleep; insomnia; caregivers; Alzheimer's disease; dementia; depression The National Alliance for Caregivers estimates that there are 44.4 million caregivers age 18 and older in the United States, representing 21% of all U.S. households. (1) The vast majority of these caregivers are women, who are either living with the care-recipient or visiting them at least weekly, and who receive no paid and very little unpaid assistance with their family member's care. In a 2003 national survey, 23% of caregivers reported that they were caring for someone with Alzheimer's disease, dementia, or other mental confusion. (1) Sleep disturbances are common among dementia caregivers. Studies over the past 15 years have reported that approximately two-thirds of older adult caregivers have some form of sleep disturbance. (2-4) Caregiver sleep problems are often presumed to be linked to nighttime behaviors in the care-recipient. Obviously, if a person with dementia is awake and roaming around the house at night, this behavior impacts the caregiver's sleep as well. In fact, research Corresponding author: Susan M. McCurry, Ph.D. UW School of Nursing 9709 3 rd Ave. NE, Ste. 507 Seattle, WA 98115-2053 smccurry@u.washington.edu 206-685-9113 (telephone) 206-616-5588 (fax). Co-authors: Logsdon, Teri: same mailing address/fax as phone/emails: 206-685-1758, logsdon@u.washington.edu; 206-543-0715, lteri@u.washington.edu Vitiello: University of Washington, Box 356560, Seattle, vitiello@u.washington.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaim...

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“…These symptoms are accompanied by behavioral and mood disturbances. In addition, insomnia is also often observed in patients with AD (1,2). It seems likely that insomnia in AD occurs by damage to the neuronal pathways that participate in the initiation and maintenance of sleep.…”

Section: Introductionmentioning

confidence: 99%

Characteristic Effects of Anti-dementia Drugs on Rat Sleep Patterns

Ishida

Kamei

2009

J Pharmacol Sci

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Abstract. The present study was undertaken to clarify the effects of anti-dementia drugs on sleep pattern in rats. Electrodes were chronically implanted into the frontal cortex and the dorsal neck muscle of rats for the electroencephalogram (EEG) and electromyogram (EMG), respectively. EEG and EMG were recorded with an electroencephalograph. SleepSigh ver. 2.0 was used for analysis of the sleep-wake state. Total times of waking, non-rapid eye movement (non-REM) sleep, and rapid eye movement (REM) sleep were measured from 10:30 to 16:30. Galantamine had no significant influence on the sleep pattern. On the other hand, donepezil and memantine showed significant increases in sleep latency and total waking time and a decrease in total non-REM sleep time. Furthermore, memantine decreased total REM sleep time. To investigate the characteristics of non-REM sleep in detail, non-REM sleep was classified as stage 1, 2, or 3 according to the depth of sleep. Different from donepezil and galantamine, memantine significantly decreased stage 1 and increased stage 3 in non-REM sleep. From these findings, it can be concluded that galantamine caused no sleep disturbance, different from donepezil and memantine.

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Sleep disturbance in mild to moderate Alzheimer's disease

Cited by 297 publications

References 36 publications

Common behavioral problems among patients with dementia attending in tertiary care hospitals in Dhaka city

Common behavioral problems among patients with dementia attending in tertiary care hospitals in Dhaka city

Sleep disturbances in caregivers of persons with dementia: Contributing factors and treatment implications

Characteristic Effects of Anti-dementia Drugs on Rat Sleep Patterns

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