Sleep disturbance induces depressive behaviors and neuroinflammation by altering the circadian oscillations of clock genes in rats

Chen, Xing; Zhou, Yanzhao; Xu, Huan; Ding, Mengnan; Zhang, Yifan; Zhang, Min; Hu, Meiru; Huang, Xin; Song, Lun

doi:10.1016/j.neures.2021.03.006

Cited by 23 publications

(23 citation statements)

References 39 publications

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“…In addition to the dermis, BP230 is also expressed in the central nervous system and an immunologic cross-reaction of the autoantibodies causing neuroinflammation might explain the BP-associated neuropsychiatric disorders ( 311 ). Circadian disruption (e.g by aging or sleep disturbance) increases neuroinflammation in rats ( 312 , 313 ) and humans ( 24 , 314 ) and might amplify neuropsychiatric symptoms in BP patients. If this scenario is translatable to shift work remains to be elucidated.…”

Section: Epidemiological and Experimental Evidence That Shift Work Co...mentioning

confidence: 99%

Potential effects of shift work on skin autoimmune diseases

2023

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Shift work is associated with systemic chronic inflammation, impaired host and tumor defense and dysregulated immune responses to harmless antigens such as allergens or auto-antigens. Thus, shift workers are at higher risk to develop a systemic autoimmune disease and circadian disruption with sleep impairment seem to be the key underlying mechanisms. Presumably, disturbances of the sleep-wake cycle also drive skin-specific autoimmune diseases, but epidemiological and experimental evidence so far is scarce. This review summarizes the effects of shift work, circadian misalignment, poor sleep, and the effect of potential hormonal mediators such as stress mediators or melatonin on skin barrier functions and on innate and adaptive skin immunity. Human studies as well as animal models were considered. We will also address advantages and potential pitfalls in animal models of shift work, and possible confounders that could drive skin autoimmune diseases in shift workers such as adverse lifestyle habits and psychosocial influences. Finally, we will outline feasible countermeasures that may reduce the risk of systemic and skin autoimmunity in shift workers, as well as treatment options and highlight outstanding questions that should be addressed in future studies.

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Section: Epidemiological and Experimental Evidence That Shift Work Co...mentioning

confidence: 99%

Potential effects of shift work on skin autoimmune diseases

2023

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“… Schnell et al [ 208 ] Rat model of depression Clock Sleep deprivation alters circadian oscillations of clock genes and causes depressive-like behavior in rats. Xing et al [ 209 ] Rat model of depression Per1, Per2 , and Bmal1 Per1, Per2 , and Bmal1 is associated with the induction of a depression-like state in the chronic mild stress model in rats. Christiansen et al [ 210 ] Mouse model of mania Clock Clock mutant mice show overall profile similar to human mania Roybal et al [ 200 ] Mouse model of mania Clock Mice with a deletion of exon 19 in the Clock gene (ClockΔ19 mice) exhibit abnormal behaviors similar to BD mania.…”

Section: Circadian Dysfunction Mtor and MDmentioning

confidence: 99%

“…A study by Schnell et al reported that the Cry1 knockout mice showed depressive-like behaviors [ 208 ]. Xing et al reported that sleep deprivation alters circadian oscillations of clock genes and causes depressive-like behavior in rats [ 209 ]. Similarly, a study by Christiansen et al reported that altered expression of clock genes ( Per1, Per2 , and Bmal1 ) is associated with the induction of a depression-like state in the chronic mild stress model in rats [ 210 ].…”

Section: Circadian Dysfunction Mtor and MDmentioning

confidence: 99%

The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model

2022

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Circadian (~24 h) rhythms in physiology and behavior are evolutionarily conserved and found in almost all living organisms. The rhythms are endogenously driven by daily oscillatory activities of so-called “clock genes/proteins”, which are widely distributed throughout the mammalian brain. Mammalian (mechanistic) target of rapamycin (mTOR) signaling is a fundamental intracellular signal transduction cascade that controls important neuronal processes including neurodevelopment, synaptic plasticity, metabolism, and aging. Dysregulation of the mTOR pathway is associated with psychiatric disorders including autism spectrum disorders (ASD) and mood disorders (MD), in which patients often exhibit disrupted daily physiological rhythms and abnormal circadian gene expression in the brain. Recent work has found that the activities of mTOR signaling are temporally controlled by the circadian clock and exhibit robust circadian oscillations in multiple systems. In the meantime, mTOR signaling regulates fundamental properties of the central and peripheral circadian clocks, including period length, entrainment, and synchronization. Whereas the underlying mechanisms remain to be fully elucidated, increasing clinical and preclinical evidence support significant crosstalk between mTOR signaling, the circadian clock, and psychiatric disorders. Here, we review recent progress in understanding the trilateral interactions and propose an “interaction triangle” model between mTOR signaling, the circadian clock, and psychiatric disorders (focusing on ASD and MD).

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“…Disruption of circadian rhythm in a mouse model decreases the expression of occludin and ZO-1 levels in respiratory mucosa [117]. The expression of TJ proteins occludin, ZO-1, and claudins has also been shown to be under circadian control in the intestine, retina, kidney, and brain [118][119][120][121]. Delineation of signaling pathways underscores the development of new strategies to restore airway TJs.…”

Section: Tj Disruption During Lung Injury Against Infectious and Infl...mentioning

confidence: 99%

Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury

et al. 2022

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Lung epithelium is constantly exposed to the environment and is critically important for the orchestration of initial responses to infectious organisms, toxins, and allergic stimuli, and maintenance of normal gaseous exchange and pulmonary function. The integrity of lung epithelium, fluid balance, and transport of molecules is dictated by the tight junctions (TJs). The TJs are formed between adjacent cells. We have focused on the topic of the TJ structure and function in lung epithelial cells. This review includes a summary of the last twenty years of literature reports published on the disrupted TJs and epithelial barrier in various lung conditions and expression and regulation of specific TJ proteins against pathogenic stimuli. We discuss the molecular signaling and crosstalk among signaling pathways that control the TJ structure and function. The Toll-like receptor-4 (TLR4) recognizes the pathogen-and damage-associated molecular patterns released during lung injury and inflammation and coordinates cellular responses. The molecular aspects of TLR4 signaling in the context of TJs or the epithelial barrier are not fully known. We describe the current knowledge and possible networking of the TLR4-signaling with cellular and molecular mechanisms of TJs, lung epithelial barrier function, and resistance to treatment strategies.

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Sleep disturbance induces depressive behaviors and neuroinflammation by altering the circadian oscillations of clock genes in rats

Cited by 23 publications

References 39 publications

Potential effects of shift work on skin autoimmune diseases

Potential effects of shift work on skin autoimmune diseases

The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model

Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury

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