Sleep disturbance mediates the relationship between depressive symptoms and cognitive function in older adults with mild cognitive impairment

Song, Dan; Jie, Zhou; Ma, Juanjuan; Chang, Jing; Qiu, Yiwen; Zhuang, Zexiang; Xiao, Huan; Zeng, Li

doi:10.1016/j.gerinurse.2021.06.004

Cited by 17 publications

(15 citation statements)

References 41 publications

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“…Quality sleep can have a significant influence on neurocognitive functioning [ 157 , 158 , 159 ]. However, age-related sleep disturbance is common [ 160 , 161 ].…”

Section: Potential Interventionsmentioning

confidence: 99%

Relationships between Inflammation and Age-Related Neurocognitive Changes

Jin

Chan

et al. 2022

IJMS

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The relationship between inflammation and age-related neurocognitive changes is significant, which may relate to the age-related immune dysfunctions characterized by the senescence of immune cells and elevated inflammatory markers in the peripheral circulation and the central nervous system. In this review, we discuss the potential mechanisms, including the development of vascular inflammation, neuroinflammation, organelle dysfunctions, abnormal cholesterol metabolism, and glymphatic dysfunctions as well as the role that the key molecules play in the immune-cognition interplay. We propose potential therapeutic pharmacological and behavioral strategies for ameliorating age-related neurocognitive changes associated with inflammation. Further research to decipher the multidimensional roles of chronic inflammation in normal and pathological aging processes will help unfold the pathophysiological mechanisms underpinning neurocognitive disorders. The insight gained will lay the path for developing cost-effective preventative measures and the buffering or delaying of age-related neurocognitive decline.

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“…Quality sleep can have a significant influence on neurocognitive functioning [ 157 , 158 , 159 ]. However, age-related sleep disturbance is common [ 160 , 161 ].…”

Section: Potential Interventionsmentioning

confidence: 99%

Relationships between Inflammation and Age-Related Neurocognitive Changes

Jin

Chan

et al. 2022

IJMS

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“…[3][4][5] Depression is characterized by negative emotions and less motivation, leading to an inability to perform daily tasks effectively, which is also associated with the declining ADLs of the elderly. [6][7][8] However, the mechanism connecting depressive symptoms and impaired ADLs in the elderly in nursing homes has not been established. Exploring the theoretical mechanisms underlying these variables may help to reduce the emotional burden on the elderly in nursing homes.…”

Section: Introductionmentioning

confidence: 99%

Activities of Daily Living and Depression in Chinese Elderly of Nursing Homes: A Mediation Analysis

Gao¹,

Yang²,

Liu³

et al. 2023

PRBM

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Purpose This study aimed to explore the role of sleep quality as a mediator in the activities of daily living (ADLs) and depression. Patients and Methods Participants (N=645; age≥60) were included in six nursing homes in Weifang, Shandong Province, using convenience sampling. Participants completed questionnaires to assess sleep quality, ADLs, and depression. Depression condition was assessed by the Patient Health Questionnaire (PHQ-9), ADLs was assessed by the Barthel Index (BI), and sleep quality was measured by the Pittsburgh Sleep Quality Index (PSQI). Mediation analysis was carried out by SPSS PROCESS. Results ADLs ( r =0.449, P <0.01) and sleep quality ( r =0.450, P <0.01) were found to be positively associated with depression among the elderly. Sleep quality plays a significant mediating role in the influence of ADLs on depression in the elderly in nursing homes (Bootstrap 95% CI [0.076, 0.139]), The pathway from ADLs to sleep quality to depression yielded a medium effect size of 20.23%. Conclusion ADLs help to explain how sleep quality partly mediates depression among the elderly in nursing homes. It is therefore recommended that timely detection and efficient interventions should focus on promoting physical function and improving sleep quality among the elderly in nursing homes.

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“…En investigaciones realizadas en China acerca de la duración del sueño y el deterioro cognitivo Liu et al (2022) evidencia que el 50% de población adulta presenta deterioro cognitivo y la existencia de una relación entre ambas variables, observando que dormir ≤6 o ≥9 horas aumenta el riesgo de un deterioro cognitivo, así como la edad avanzada, el ser mujer, la dificultad en las actividades de la vida diaria (AVD) y la soltería. De igual manera, Song et al (2021) en su estudio en adultos mayores con deterioro cognitivo leve identifica que el 74,5% presenta alteraciones de sueño, así como una relación entre calidad de sueño y la función cognitiva. Asimismo, Zhao et al ( 2021) observa el 47.1% tiene mala calidad de sueño, cuando existe un riesgo de desnutrición son propensos a tener mala calidad de sueño, además, la corta duración de sueño (≤ 6h) en mujeres y larga (≥ 9h) en hombres están relacionados al riesgo de desnutrición.…”

Section: Introductionunclassified

Funcionamiento cognitivo y calidad de sueño en adultos mayores

Poaquiza

Manzano

2023

LATAM

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La población adulta mayor a nivel mundial va en aumento, la misma que requiere de atención primaria debido a que la vejez viene acompañada de signos y síntomas propios de la edad conocidos como síndromes geriátricos. El objetivo del estudio fue determinar la relación entre el funcionamiento cognitivo y calidad de sueño en adultos mayores. El enfoque de la investigación fue cuantitativo, de alcance correlacional, corte transversal. La muestra no probabilística por conveniencia estuvo conformada por 127 adultos mayores con un rango de edad de 60-104 años con una media de 78.5 años, 42 hombres (33.1%) y 85 mujeres (66.9%). Para evaluar las funciones cognitivas se aplicó el Mini-Examen Cognoscitivo (MEC) y la calidad de sueño mediante el Índice de Calidad de sueño de Pittsburgh (PSQI). Los niveles predominantes del estado cognitivo determinaron la presencia de un déficit discreto, mientras que prevalece una mala calidad de sueño. Al comparar el sexo y el funcionamiento cognitivo se evidenció que no existe diferencias significativas. Finalmente, los resultados revelan la ausencia de relación entre el funcionamiento cognitivo y calidad de sueño (Rho=-0.072, p >0.05), es decir, el estado de las funciones cognitivas no se relaciona con la calidad de sueño en el adulto mayor.

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Sleep disturbance mediates the relationship between depressive symptoms and cognitive function in older adults with mild cognitive impairment

Cited by 17 publications

References 41 publications

Relationships between Inflammation and Age-Related Neurocognitive Changes

Relationships between Inflammation and Age-Related Neurocognitive Changes

Activities of Daily Living and Depression in Chinese Elderly of Nursing Homes: A Mediation Analysis

Funcionamiento cognitivo y calidad de sueño en adultos mayores

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