Sleep disturbances among patients with epilepsy in Nigeria

Komolafe, Morenikeji; Sunmonu, Taofiki; Ogunrin, Olubunmi; Disu, Jimoh O; Ezeala, Birinus; Abubakar, Sani; Iwuoso, Emmanuel

doi:10.4103/1596-3519.149880

Cited by 17 publications

(4 citation statements)

References 24 publications

(41 reference statements)

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“…Our main objective was to identify sleep disorders in patients with epilepsy. Our study showed that depression is more common in patients with epilepsy than in healthy controls, as also indicated previously 15,16 . The higher frequency of depression in patients with epilepsy can be explained as an effect of having a chronic disease 17 .…”

Section: Discussionsupporting

confidence: 91%

Depression is a major determinant of sleep abnormalities in patients with epilepsy

Karapinar

Yunusoğlu

Tekin

et al. 2020

Arq. Neuro-Psiquiatr.

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Introduction: We aimed to identify sleep disorders in patients with epilepsy and compare this group with a healthy population. We also analyzed the features of sleep disorders in patients with epilepsy to demonstrate the effect of seizures and seizure types on sleep. Methods: Our study assessed 43 patients with epilepsy and 53 age- and gender-matched healthy controls. The demographic and clinical data of all participants were recorded. The Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index (PSQI), International Restless Legs Syndrome Study Group Rating Scale, Berlin Questionnaire, and Beck Depression Inventory (BDI) were administered to all study subjects. The interview used to evaluate insomnia is based on the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition - DSM-5 diagnostic criteria. Results: Twenty-four patients (55.8%) and 26 controls (49.1%) are women. The mean age of patients and controls was 34.2±11.37 (16-71) and 34.6±11.28 (16-77), respectively. Patients with epilepsy had depression more often than controls, a result that was statistically significant (p<0.0001). We found no statistically significant difference between sleep parameters of patients and controls with normal BDI scores (p>0.05). Patients with depression had worse results on the Berlin Questionnaire and PSQI total score, with statistical significance (p=0.002). Nocturnal seizures, seizure type, and drug treatment had no effect on sleep (p>0.05). Conclusion: We concluded that depression rather than epilepsy negatively affects sleep, suggesting that all patients should be asked about their mood and sleep complaints.

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Section: Discussionsupporting

confidence: 91%

Depression is a major determinant of sleep abnormalities in patients with epilepsy

Karapinar

Yunusoğlu

Tekin

et al. 2020

Arq. Neuro-Psiquiatr.

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“…In contrast to earlier observations made by Klobucnikova et al [12] who compared epilepsy patients showing clinical epileptic seizures at night with patients suffering from epilepsy but did not show epileptic seizures while sleeping, in this study, we could not find that epilepsy patients had In this study, we found that epilepsy may have a negative impact on sleep. This was consistent with previous studies, which suggested that epilepsy can worsen sleep architecture and severity of sleep disorders [13][14][15][16]. Possibly the repetitive seizures impacted the sleep by reducing total sleep time and decreasing REM [13].…”

Section: Discussionsupporting

confidence: 92%

Spontaneous Arm Movement Activity during Sleep in Epileptic and Non-Epileptic Patients

Ruan

Seitz

2018

Eur Neurol

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Purpose: Epilepsy has a complex interaction with sleep. The purpose of this study was to explore the relation between spontaneous arm movements and sleep architecture in patients with epilepsy. Methods: This prospective study included 53 patients with suspected epilepsy (44 ± 18 years; 30 females, 23 males) and 55 age-matched patients with non-epileptic seizures (42 ± 15: 27 females, 28 males). Twenty-four-hour-video-electroencephalography recordings were combined with accelerometry of movement activity of both arms using actiwatches. Results: Patients with suspected epilepsy showed a higher occurrence of epileptic discharges (p = 0.0001) and abnormal focal slowing (p = 0.027) in the electroencephalogram (EEG) than the patients with non-epileptic seizures. Also, the epilepsy patients showed a shorter rapid eye movement-sleep duration compared to controls (0.0001). Accelerometry revealed that the patients with epilepsy moved their dominant right arm more frequently during the night (p = 0.014) than the controls, although there was no difference in arm movement activity during day time. Conclusion: The patients with reported epilepsy exhibited higher spontaneous arm movement activity during sleep. This may be related to abnormal sleep architecture or abnormal EEG activity but was not related to epileptic seizures.

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“…The finding from this study was lower than a study conducted in Nigeria [39]. The variation may be due to measurement tool difference (Epworth sleepiness score tool was used in a study conducted in Nigeria whereas the PSQI tool was used in this study).…”

Section: Discussioncontrasting

confidence: 72%

Sleep quality and associated factors among adult patients with epilepsy attending follow-up care at referral hospitals in Amhara region, Ethiopia

2021

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Background Globally, epilepsy is the commonest neurological disorder in adults. It has significant health and economic consequences to the affected individuals and the family. There is ample evidence that epileptic patients are at increased risk of poor sleep quality than the general population. However, there is limited evidence on sleep quality among epileptic patients and associated factors in Ethiopia. Therefore, this study investigated the prevalence of poor sleep quality and associated factors among adult patients with epilepsy. Method Institutional based cross-sectional study was conducted among adult epileptic patients attending follow-up care at referral hospitals in the Amhara region. A total of 575 epileptic patients were recruited using a stratified systematic random sampling technique. An interviewer-administered semi-structured questionnaire and record review were used for data collection. To assess sleep quality the pretested Pittsburgh Sleep Quality Index (PSQI) tool was used. A binary logistic regression model was used to assess factors associated with poor sleep quality. Variables with a p-value less than 0.2 in the bivariable binary logistic regression analysis were considered for the multivariable binary logistic regression analysis. In the multivariable binary logistic regression analysis, the Adjusted Odds Ratio (AOR) with the 95% Confidence Interval (CI) were reported to declare the statistical significance and strength of association. Model fitness was assessed using the Hosmer-Lemeshow test and was adequate (p>0.05). Multicollinearity of the independent variables was assessed using the Variance Inflation Factor (VIF) and the mean VIF was less than 10. Results A total of 565 participants were enrolled in the study with a response rate of 98.3%. The prevalence of poor sleep quality among adult epileptic patients was 68.8% [95% CI: 64.8%, 72.5%]. In the multivariable binary logistic regression, being unable to read and write [AOR = 3.16, 95%CI: 1.53, 6.51], taking polytherapy treatment [AOR = 2.10, 95% CI: 1.37, 3.21], poor medication adherence [AOR = 2.53, 95%CI: 1.02, 6.23] and having poor support [AOR = 2.72, 95%CI: 1.53, 4.82] and moderate social support [AOR = 1.89, 95%CI: 1.05, 3.41] were significantly associated with higher odds of poor sleep quality. Conclusion and recommendation Poor sleep quality is a major public health concern in Ethiopia. The patient’s level of education, number of medication use, medication adherence, and social support were found significant predictors of poor sleep quality. These findings highlight improving medication adherence and social support are effective strategies to improve the sleep quality of epileptic patients. Besides, it is better to give special emphasis to those epileptic patients with a low level of education and taking polytherapy to enhance sleep quality.

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Sleep disturbances among patients with epilepsy in Nigeria

Abstract: There is a high frequency of sleep disorders among PWE. Clinicians should screen PWE for sleep disturbances.

Cited by 17 publications

References 24 publications

Depression is a major determinant of sleep abnormalities in patients with epilepsy

Depression is a major determinant of sleep abnormalities in patients with epilepsy

Spontaneous Arm Movement Activity during Sleep in Epileptic and Non-Epileptic Patients

Sleep quality and associated factors among adult patients with epilepsy attending follow-up care at referral hospitals in Amhara region, Ethiopia

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