Sleep disturbances and impaired daytime functioning in outpatients with newly diagnosed lung cancer

Guen, Y. Le; Gagnadoux, Frédéric; Hureaux, J.; Jeanfaivre, T.; Meslier, Nicole; Racineux, Jean-Louis; Urban, T.

doi:10.1016/j.lungcan.2007.05.021

Cited by 63 publications

(52 citation statements)

References 27 publications

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“…Given the noticeable difference in fatigue between these groups, a difference in the incidence of insomnia would be expected. Our results, however, are in line with other studies that found a discrepancy between subjective and objective sleep disturbances in lung cancer patients [48,49].…”

Section: Physical Outcomessupporting

confidence: 93%

Denial and physical outcomes in lung cancer patients, a longitudinal study

et al. 2010

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Section: Physical Outcomessupporting

confidence: 93%

Denial and physical outcomes in lung cancer patients, a longitudinal study

et al. 2010

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“…This lack of association between sleep measured objectively and subjectively was consistent with other previous studies. [6][7][8][45][46][47][48][49][50][51] A possible explanation for this finding is that there is a difference between current sleep and usual sleep before their diagnosis of cancer. Patients might still be sleeping reasonably well but that might be worse than their expectation.…”

Section: Discussionmentioning

confidence: 99%

Association between Daytime Activity, Fatigue, Sleep, Anxiety, Depression, and Symptom Burden in Advanced Cancer Patients: A Preliminary Report

Yennurajalingam

Tayjasanant

Balachandran

et al. 2016

Journal of Palliative Medicine

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Background: There is limited research in advanced cancer patients (ACP) regarding association between objectively measured daytime activity and sleep (as measured by actigraphy), patient characteristics, and cancer symptoms (fatigue, sleep, anxiety, depression, cachexia, and symptom distress scores [SDSs]). Objectives: Our aim of the study was to determine the association between mean daytime activity (MDTA) and the following items: fatigue (FACIT-F), SDSs (Edmonton Symptom Assessment Scale [ESAS]), sleep quality (Pittsburg Sleep Quality Index [PSQI]), objective sleep variables (OSV) (sleep onset, sleep efficacy, wake after sleep onset, total sleep time), anxiety and depression (Hospital Anxiety and Depression Scale [HADS]), body composition scores, and overall survival (OS). We also examined the association between sleep [PSQI and OSV scores] and FACIT-F, HADS, and ESAS. Methods: Secondary analysis of a recent clinical trial of cancer-related fatigue in advanced cancer (NCT00424099). Association between MDTA and OSV (measured by actigraphy) during the first week of the study and patient characteristics, symptoms (FACIT-F, ESAS, HADS, and PSQI), and OS were analyzed. Results: Seventy-nine eligible patients were evaluable. The median age was 57 years. Median MDTA was 248.43 counts/minute. Multivariate analysis shows that low MDTA was significantly associated with age, gender, Functional Assessment of Cancer Therapy (FACT)-Functional Well-Being (FWB), ESAS dyspnea, HADS-anxiety, and total sleep time. MDTA was not associated with FACIT-F ( p = 0.997) and OS ( p = 0.18). Sleep quality (PSQI) was significantly associated with FACIT-F, HADS, ESAS anxiety, and depression, but none of these variables was associated with OSV. Conclusion: In ACP, lower MDTA was significantly associated with age, gender, FACT-FWB, ESAS dyspnea, HADS-anxiety, and total sleep time. Both sleep quality and cancer-related fatigue scores were strongly associated with depression and anxiety. More research is needed.

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“…These results indicate better sleep quality in our sample of lung cancer patients than in previous studies in which the PSQI was used to measure sleep qual- Table 5 Correlations between predictors and outcome variables [36], some lung cancer patients were assessed for sleep quality during chemotherapy at hospital and some were assessed before chemotherapy at ambulatory or home settings. In Le Guen et als' study [10], patients were measured before the start of chemotherapy or any other anticancer treatment while in Vena et al's study [9], the treatment phase was not clear. Our findings on PSQI global scores are comparable to findings (PSQI global score = 6.3) from Gooneratne et al's study [20] with a sample of elderly lung cancer survivors (>5 years).…”

Section: Discussionmentioning

confidence: 99%

“…However, unlike other cancer-related symptoms such as pain, depression, and fatigue, insomnia in the cancer population has received little attention from clinicians or researchers [3,7]. Cancer patients have consistently been shown to have significantly poorer sleep quality than healthy adults or non-cancer patients [8][9][10]. The prevalence of sleep disturbances reported for 982 patients with various cancers (breast, gastrointestinal, genitourinary, gynecologic, lung, and non-melanoma skin cancers) [11] was highest or second highest among lung cancer patients.…”

Section: Introductionmentioning

confidence: 99%