Sleep disturbances in autism spectrum disorder without intellectual impairment: relationship with executive function and psychiatric symptoms

Gisbert, Laura; Marín, Jorge Lugo; Ramos, Imanol Setien; Jimenez, Pol Ibañez; Romero, Odile; Jurado-Luque, María José; Ballester, Pura; Cruella, Antoni Esteve; Villoria, Emiliano Díez; Canal‐Bedia, Ricardo; Quiroga, Josep Antoni Ramos

doi:10.1016/j.sleep.2021.04.022

Cited by 13 publications

(11 citation statements)

References 82 publications

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“…Following the historic pattern present in ASD and sleep research, the majority of studies in the past 3 years document how sleep is associated with other aspects of context, autism, and/or development. Sleep in autism is associated with (1) demographic factors [ 75 – 77 ], (2) challenging behaviors [ 36 , 78 – 87 ], (3) core ASD symptoms [ 38 , 65 , 77 ], and (4) other psychiatric symptoms [ 84 , 88 , 89 ]. Studies with a developmental focus also document correlations with executive functioning [ 88 , 90 ], memory [ 91 – 93 ], attention [ 79 , 94 ], and phonological learning [ 95 ].…”

Section: Discussionmentioning

confidence: 99%

“…Sleep in autism is associated with (1) demographic factors [ 75 – 77 ], (2) challenging behaviors [ 36 , 78 – 87 ], (3) core ASD symptoms [ 38 , 65 , 77 ], and (4) other psychiatric symptoms [ 84 , 88 , 89 ]. Studies with a developmental focus also document correlations with executive functioning [ 88 , 90 ], memory [ 91 – 93 ], attention [ 79 , 94 ], and phonological learning [ 95 ].…”

Section: Discussionmentioning

confidence: 99%

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Sleep in Children with Autism Spectrum Disorder: A Narrative Review and Systematic Update

Schwichtenberg

Janis

Lindsay

et al. 2022

Curr Sleep Medicine Rep

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Purpose of Review Sleep problems are a common comorbidity for children with autism spectrum disorder (ASD), and research in this area has a relatively long history. Within this review, we first outline historic patterns in the field of sleep and ASD. Second, we conducted a systematic update and coded these studies based on their alignment with historic patterns. Research on ASD and sleep over the past two decades has primarily focused on four principal areas: (1) documenting the prevalence and types of sleep problems; (2) sleep problem treatment options and efficacy; (3) how sleep problems are associated with other behavioral, contextual, or biological elements; and (4) the impact of child sleep problems on families and care providers. The systematic update in this paper includes empirical studies published between 2018 and 2021 with terms for sleep and ASD within the title, keywords, or abstract. Recent Findings In sum, 60 studies fit the inclusion/exclusion criteria and most fit within the historic patterns noted above. Notable differences included more global representation in study samples, studies on the impacts of COVID-19, and a growing body of work on sleep problems as an early marker of ASD. The majority of studies focus on correlates of sleep problems noting less optimal behavioral, contextual, and biological elements are associated with sleep problems across development for children with ASD. Summary Recommendations for future directions include continued expansion of global and age representation across samples, a shift toward more treatment and implementation science, and studies that inform our mechanistic understanding of how sleep and ASD are connected. Supplementary Information The online version contains supplementary material available at 10.1007/s40675-022-00234-5.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sleep in Children with Autism Spectrum Disorder: A Narrative Review and Systematic Update

Schwichtenberg

Janis

Lindsay

et al. 2022

Curr Sleep Medicine Rep

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“…Sleep disturbances are primary comorbid conditions across the four disorders ASD, SCZ, BP, and MDD. Most ASD patients suffer from sleep disturbance [ 101 , 102 ], often characterized by insomnia. Similarly, SCZ and the manic phase of BP share the reduced need for sleep [ 103 , 104 , 105 , 106 ].…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Profiling of Dysregulated GPCRs Reveals Overlapping Patterns across Psychiatric Disorders and Age-Disease Interactions

Monfared

Alhassen

Truong

et al. 2021

Cells

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G-protein-coupled receptors (GPCRs) play an integral role in the neurobiology of psychiatric disorders. Almost all neurotransmitters involved in psychiatric disorders act through GPCRs, and GPCRs are the most common targets of therapeutic drugs currently used in the treatment of psychiatric disorders. However, the roles of GPCRs in the etiology and pathophysiology of psychiatric disorders are not fully understood. Using publically available datasets, we performed a comprehensive analysis of the transcriptomic signatures of G-protein-linked signaling across the major psychiatric disorders: autism spectrum disorder (ASD), schizophrenia (SCZ), bipolar disorder (BP), and major depressive disorder (MDD). We also used the BrainSpan transcriptomic dataset of the developing human brain to examine whether GPCRs that exhibit chronological age-associated expressions have a higher tendency to be dysregulated in psychiatric disorders than age-independent GPCRs. We found that most GPCR genes were differentially expressed in the four disorders and that the GPCR superfamily as a gene cluster was overrepresented in the four disorders. We also identified a greater amplitude of gene expression changes in GPCRs than other gene families in the four psychiatric disorders. Further, dysregulated GPCRs overlapped across the four psychiatric disorders, with SCZ exhibiting the highest overlap with the three other disorders. Finally, the results revealed a greater tendency of age-associated GPCRs to be dysregulated in ASD than random GPCRs. Our results substantiate the central role of GPCR signaling pathways in the etiology and pathophysiology of psychiatric disorders. Furthermore, our study suggests that common GPCRs’ signaling may mediate distinct phenotypic presentations across psychiatric disorders. Consequently, targeting these GPCRs could serve as a common therapeutic strategy to treat specific clinical symptoms across psychiatric disorders.

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“…Executive functions have an important role in everyday behaviors across the life span ( 6 ). Literature showed that the impairment of executive functions might associate with worse core symptoms ( 7 , 8 ), poor quality of life ( 9 ), and impaired mental and physical health ( 10 – 12 ) in children with ASD. Thus, exploring the risk factors for the impairment of executive functions in children with ASD is become increasingly important and will help to propose feasible treatment intervention plans for children with ASD in the future.…”

Section: Introductionmentioning

confidence: 99%

Association between dietary quality and executive functions in school-aged children with autism spectrum disorder

et al. 2022

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BackgroundIt is well known that children with autism spectrum disorder (ASD) had executive functions deficit. However, it is still unclear whether the poor dietary quality is related to the impairment of executive functions. The current study aimed to explore the association between dietary quality and executive functions in children with ASD.MethodsA total of 106 children with ASD (7.7 ± 1.3 years) and 207 typically developing (TD) children (7.8 ± 1.3 years) were enrolled from Guangzhou, China. The Chinese version of Behavior Rating Scale of Executive function (BRIEF), the working memory subscales of the Chinese version of Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV), and the Stroop Color-Word Test (SCWT) were used to measure the participant's executive functions. The food frequency questionnaire (FFQ) was used to collect the dietary intake information, and the Chinese Diet Balance Index (DBI_16) was used to evaluate the dietary quality. Generalized linear models were used to estimate the association between dietary quality and executive functions.ResultsIn children with ASD, Low Bound Score (LBS) was positively correlated with the working memory subscale score of BRIEF (β = 0.23, 95% CI: 0.02–0.44, P < 0.05), while High Bound Score (HBS) and LBS were positively correlated with the organizable subscale score of BRIEF (β = 0.44, 95% CI: 0.11–0.77, P < 0.01; β = 0.19, 95% CI: 0.01–0.37, P < 0.05). Compared to TD children, children with ASD had a higher proportion of moderate and high levels of insufficient dietary intake (moderate level, 37.7% vs. 23.2%, high level, 4.7% vs. 1.4%) and moderate level of unbalanced dietary intake (36.8% vs.21.3%), higher scores on all subscales of BRIEF (P < 0.01), and lower score on the working memory (81.3 ± 32.3 vs. 104.6 ± 12.5, P < 0.01), while there was no difference on the SCWT.ConclusionPoor dietary quality was associated with the impairment of working memory and organizational capacity in children with ASD. This study emphasized the importance of dietary quality in executive functions among children with ASD, and attention should be paid to improving their dietary quality.

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Sleep disturbances in autism spectrum disorder without intellectual impairment: relationship with executive function and psychiatric symptoms

Cited by 13 publications

References 82 publications

Sleep in Children with Autism Spectrum Disorder: A Narrative Review and Systematic Update

Sleep in Children with Autism Spectrum Disorder: A Narrative Review and Systematic Update

Transcriptome Profiling of Dysregulated GPCRs Reveals Overlapping Patterns across Psychiatric Disorders and Age-Disease Interactions

Association between dietary quality and executive functions in school-aged children with autism spectrum disorder

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