Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance

Carbone, Elvira Anna; Menculini, Giulia; Filippis, Renato de; D'Angelo, Martina; Fazio, Pasquale De; Tortorella, Alfonso; Steardo, Luca

doi:10.3390/ijerph20054431

Cited by 9 publications

(5 citation statements)

References 109 publications

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“…These essential ions play a crucial role in maintaining proper fluid-electrolyte balance and regulating neural activity. [28][29][30][31] CKD patients typically exhibit decreased levels of these ions, which could ultimately lead to central or peripheral nerve dysfunction, including poor sleep quality and RLS. Appropriate electrolyte supplementation may be an easy and effective solution for improving poor sleep quality.…”

Section: Discussionmentioning

confidence: 99%

Risk factors affecting the sleep quality of patients on dialysis: A single-center cross-sectional study

Peng,

Huang,

Liao

et al. 2024

Medicine

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Sleep quality is among the common complication in patients on dialysis and serious affect their health and quality of life; however, other associated risk factors are unclear. This study aimed to investigate the risk factors affecting sleep quality in patients on dialysis. Data were collected from 260 patients who met the inclusion criteria at out hospital from May 2023 to October 2023. Questionnaires were completed by patients, and biochemical indicators were obtained from past medical records. Univariate and multifactor analyses were used to find factors influencing sleep quality in patients on dialysis. Simple linear regression results showed that female, type of kidney primary disease, high systolic blood pressure (SBP), pruritus, pruritus frequency, restless legs syndrome (RLS), anxiety, and depression were associated with poor sleep quality. Blood biochemical parameters showed that low sodium and calcium levels and high ferritin levels were associated with poor sleep quality. Multiple linear regression statistics showed that female, pruritus, RLS, high SBP, depression, and high ferritin levels were associated with poor sleep quality. This study showed that female, chronic nephritis syndrome, high SBP, pruritus, RLS, low mood. and high ferritin levels were associated with poor sleep quality. Future development of individual nursing and targeted therapies is key to improving sleep quality in patients on dialysis.

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Section: Discussionmentioning

confidence: 99%

Risk factors affecting the sleep quality of patients on dialysis: A single-center cross-sectional study

Peng,

Huang,

Liao

et al. 2024

Medicine

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“…The regression models showed that patients with generalized anxiety disorder displaying low levels of vitamin D demonstrate a poor subjective quality of sleep and heightened anxiety. A strong relationship between peripheral biomarkers of calcium homeostasis imbalance, insomnia, poor sleep quality, and anxiety symptomatology was underlined ( Carbone et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of fecal microbiota transplantation for chronic insomnia in adults: a real world study

Fang,

Yao,

et al. 2023

Front. Microbiol.

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ObjectiveTo assess the efficacy and safety of fecal microbiota transplantation (FMT) for adult chronic insomnia.MethodsPatients treated with FMT for chronic diseases were divided into chronic insomnia and non-insomnia group. The primary endpoint was the efficacy of FMT for insomnia 4 weeks after treatment, the secondary endpoints included the impacts of FMT on anxiety, depression, health-related quality of life, gut microbiota, and adverse events associated with FMT. Insomnia Severity Index (ISI) and Pittsburgh Sleep Quality Index (PSQI) were utilized to assess the efficacy of FMT on insomnia, self-rating anxiety/depression scale [Zung Self-Rating Anxiety Scale (SAS), Zung Self-Rating Depression Scale (SDS)] was employed to evaluate anxiety and depression. Quality of life was evaluated by SF-36. 16S rRNA sequencing was employed to analyze the gut microbiota and correlation analysis was performed.ResultsForty patients met the inclusion criteria and seven were excluded. 33 patients were enrolled and stratified into chronic insomnia group (N = 17) and non-insomnia group (N = 16). Compared to baseline, FMT significantly ameliorated the ISI (17.31 ± 5.12 vs. 5.38 ± 5.99), PSQI (14.56 ± 2.13 vs. 6.63 ± 4.67), SAS (54.25 ± 8.90 vs. 43.68 ± 10.64) and SDS (57.43 ± 10.96 vs. 50.68 ± 15.27) score and quality of life of chronic insomnia patients. 76.47% (13/17) of insomnia patients achieved the primary endpoints. In chronic insomnia patients, the relative abundance of Eggerthella marked enhanced at baseline, while the relative abundance of Lactobacillus, Bifidobacterium, Turicibacter, Anaerostipes, and Eisenbergiella significantly increased after FMT treatment, the latter positive correlated with the efficacy of FMT. Encouragingly, FMT also improved the sleep quality of non-insomnia patients.ConclusionEggerthella may potentially serve as a distinctive genus associated with chronic insomnia. FMT maybe a novel treatment option for adults with chronic insomnia and provide an alternative to traditional treatments for insomnia. The effects were positive correlated with the augmentation of probiotics, such as Bifidobacterium, Lactobacillus, Turicibacter, and Fusobacterium.

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“…Imbalanced calcium homeostasis [125] Interference in serotonin synthesis by expression of the serotonin-synthesizing gene, therefore maintaining serotonin within the normal range [126] Mediation of several pathways for insulin or serotonin which were associated with mood disorders [127] Obsessive-compulsive disorder Elusive underlying mechanism [80] Trauma-and stress-related disorders Vitamin D regulates neuro-inflammatory and neuro-immunological mechanisms [82] Brain areas with altered activity in patients with PTSD express vitamin D receptors in the prefrontal cortex, cingulate cortex, and hypothalamus [9] Vitamin D mediates the regulation of serotonin and catecholamine [83] Eating disorder Vitamin D deficiency as a consequence [87] Sleep-wake disorder Vitamin D deficiency is associated with lower sleep duration, worse sleep quality, an increase in time of sleep onset in pediatric populations, and circadian rhythm regulation [95] Elimination disorders Prostatic cells can express a hydroxylase that can synthesize the active form of vitamin D [90] Vitamin D receptors are located in the urinary bladder and pelvic floor muscles [91] Sexual disorders Low levels of vitamin D are associated with an increased risk for atherosclerotic events through inflammation, endothelial dysfunction, atherosclerosis, and impaired glucose metabolism [104] Receptors of 1,25(OH)2-D3 inhibit the expression of inducible nitric oxide NO synthetase [128] Neurocognitive disease Important role in memory formation; the active form of vitamin D supports neurotransmission, neuroprotection, and synaptic plasticity [110] Vitamin D receptors are present in the hippocampus. They are responsible for blocking calcium influx and also the toxicity in cultured mesencephalic neurons or hippocampal neurons [129] To our knowledge, this is the first review that compared all psychiatric diseases and analyzed the known information on vitamin D deficiency's influence.…”

Section: Anxiety Disordersmentioning

confidence: 99%

Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology

Ciobanu,

Petrescu,

Anghele

et al. 2023

Medicina

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In the last few years, vitamin D functions have been studied progressively, and along with their main role in regulating calcium homeostasis, the potential function in the nervous system and the link between different psychiatric disorders and vitamin D deficiency have been revealed. The discovery of vitamin D receptors in multiple brain structures, like the hippocampus, led to the hypothesis that vitamin D deficiency could be responsible for treatment resistance in psychiatric diseases. The aim of this study was to analyze the current knowledge in the literature regarding vitamin D deficiency among individuals afflicted with psychiatric disorders and assess the potential therapeutic benefits of vitamin D supplementation. A systematic search was conducted on the PubMed database for articles published in the last five years (2016–2022) in English, focusing on human subjects. Results show that vitamin D deficiency has implications for numerous psychiatric disorders, affecting mood and behavior through its influence on neurotransmitter release, neurotrophic factors, and neuroprotection. It also plays a role in modulating inflammation, which is often elevated in psychiatric disorders. In conclusion, vitamin D deficiency is prevalent and has far-reaching implications for mental health. This review underscores the importance of exploring the therapeutic potential of vitamin D supplementation in individuals with psychiatric disorders and highlights the need for further research in this complex field.

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Sleep Disturbances in Generalized Anxiety Disorder: The Role of Calcium Homeostasis Imbalance

Cited by 9 publications

References 109 publications

Risk factors affecting the sleep quality of patients on dialysis: A single-center cross-sectional study

Risk factors affecting the sleep quality of patients on dialysis: A single-center cross-sectional study

Efficacy and safety of fecal microbiota transplantation for chronic insomnia in adults: a real world study

Severe Vitamin D Deficiency—A Possible Cause of Resistance to Treatment in Psychiatric Pathology

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