Sleep Disturbances in HIV-Seropositive Patients

Norman, Suzan E.; Resnick, Lionel; Cohn, Martin A.; Duara, Ranjan; Herbst, Jay S.; Berger, Joseph

doi:10.1001/jama.1988.03410070046015

Cited by 52 publications

(21 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sleep architecture in HIV patients was previously characterized: increased sleep latency, increased frequency of nocturnal awakenings, reduced number of hours of sleep, early morning awakening with reversal of the slow wave sleep, particular rapid eye movement sleep patterns [1,15]. We confirmed increased sleep latency in HIV patients under age 50, according to PSQI.…”

Section: Discussionsupporting

confidence: 79%

Characteristics of sleep disorders in Romanian adults infected with human immunodeficiency virus

Arbune

Dumitru

Cretu-Stuparu

2017

ARS Medica Tomitana

View full text Add to dashboard Cite

Sleep disorders commonly occur in chronic diseases and are a great impairment on the quality of life. The current study aims to characterize the sleep problems of a group of Romanian HIV positive patients. A cross sectional study assessed sleep disorders by a series of self-report questionnaires: STOP-BANG, Epworth Sleep Questionnaire and Pittsburgh Sleep Quality Index. Demographic data, antiretroviral therapy, Lymphocytes CD4 levels were collected from medical records. Exclusion criteria were illiteracy, severe neurocognitive dysfunction and depression. We included 102 patients infected with human immunodeficiency virus, age between 22 and 50, sex ratio M/F=1.17. Reported conditions related to sleep disorders were: smoking (50%), hypertension (18%), obesity (6%) and snoring (7%). The STOP-BANG scale indicated 19% intermediate risk and 2% high risk of sleep apnea. According to Epworth score, daytime sleepiness was found in 18% of patients, 2% of them were dangerously sleepy. The average global score of Pittsburg Sleep Questionnaire is indicative of poor sleep quality in 42% cases. No correlation of sleep scores with antiretroviral regimens was found. Sleep problems with negative impact on daily functioning are frequent

show abstract

Section: Discussionsupporting

confidence: 79%

Characteristics of sleep disorders in Romanian adults infected with human immunodeficiency virus

Arbune

Dumitru

Cretu-Stuparu

2017

ARS Medica Tomitana

View full text Add to dashboard Cite

show abstract

“…In addition, abnormal sleep patterns, similar to the findings of this study, have also been reported in HIV-infected individuals (Aldrich et al, 1988;St. Kubicki et al, 1988;Rothenberg et at., 1990;Norman et al, 1988Norman et al, , 1990Norman et al, , 1992. Finally, decreased coordination and slowed reflexes are common in HIV-infected individuals (Karlsen et al, 1992;Orefice et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the evoked potential studies, one control cat and one FIV-infected cat were surgically implanted with permanent nichrome screw electrodes to assess further the potential EEG abnormalities and sleep-wake changes previously observed in human HIV-infected subjects (St. Kubicki et al, 1988;Norman et al, 1988Norman et al, , 1990Norman et al, , 1992. Nine electrodes were placed in the skull and nuchal musculature and were mounted in an acrylic headmount to monitor behavioural state.…”

Section: T R Phillips and Othersmentioning

confidence: 99%

Neurological Abnormalities Associated with Feline Immunodeficiency Virus Infection

Phillips

Prospéro-Garcı́a²,

Puaoi³

et al. 1994

Journal of General Virology

126

View full text Add to dashboard Cite

Specific pathogen-free cats were infected with the Maryland strain of FIV (FIV-MD) for the purpose of assessing the effects of FIV infection on the central nervous system (CNS). Two separate studies were performed, involving a total of 13 infected cats and six age-matched, sham-inoculated controls. All animals infected with FIV-MD seroconverted by 8 weeks postinfection and virus was recovered from peripheral blood mononuclear cells of all infected cats. All of the infected animals had lower absolute CD4 + cell counts and decreased CD4+/CD8 ÷ ratios. Virus was recovered from the cerebrospinal fluid (CSF) of certain infected individuals, and antiviral antibody and pleocytosis were evident in the CSF of the majority of infected cats.Additionally, virus was recovered from tissue explants from the cerebellum, midbrain and brainstem of one sacrificed FIV + eat. Specific neurological changes ineluded anisocoria, delayed righting reflex and delayed pupillary reflex, as well as delayed visual and auditory evoked potentials, and marked alterations in sleep patterns similar to those reported for human immunodeficiency virus (HIV)-positive individuals. Histological evaluation revealed the presence of perivascular cuffing and glial nodules in FIV-infected cats. These results indicate that FIV causes an acute neurological disease that closely resembles the early neurological effects of HIV infection in humans and should serve well as an animal model for lentivirus-induced CNS disease.

show abstract

“…Sleep disturbances are reported, with polysomnographic studies indicating a distortion of sleep architecture (271,272), and both focal and generalized seizures have been described (19,168,283). In fact, in a large percentage of HIV-1-infected persons with seizures, no etiology other than HIV-1 could be identified for the seizures (19,168).…”

Section: Hiv-1 Encephalopathy (Hiv-1-associatedmentioning

confidence: 99%

Human immunodeficiency virus type 1 infection of the brain

et al. 1993

View full text Add to dashboard Cite

Direct infection of the central nervous system by human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS, was not appreciated in the early years of the AIDS epidemic. Neurological complications associated with AIDS were largely attributed to opportunistic infections that arose as a result of the immunocompromised state of the patient and to depression. In 1985, several groups succeeded in isolating HIV-1 directly from brain tissue. Also that year, the viral genome was completely sequenced, and HIV-1 was found to belong to a neurotropic subfamily of retrovirus known as the Lentivirinae. These findings clearly indicated that direct HIV-1 infection of the central nervous system played a role in the development of AIDS-related neurological disease. This review summarizes the clinical manifestations of HIV-1 infection of the central nervous system and the related neuropathology, the tropism of HIV-1 for specific cell types both within and outside of the nervous system, the possible mechanisms by which HIV-1 damages the nervous system, and the current strategies for diagnosis and treatment of HIV-1-associated neuropathology.

show abstract

Sleep Disturbances in HIV-Seropositive Patients

Cited by 52 publications

References 1 publication

Characteristics of sleep disorders in Romanian adults infected with human immunodeficiency virus

Characteristics of sleep disorders in Romanian adults infected with human immunodeficiency virus

Neurological Abnormalities Associated with Feline Immunodeficiency Virus Infection

Human immunodeficiency virus type 1 infection of the brain

Contact Info

Product

Resources

About