Sleep disturbances in multiple sclerosis

Caminero, Ana B.; Bartolomé, Manuel

doi:10.1016/j.jns.2011.07.015

Cited by 97 publications

(76 citation statements)

References 71 publications

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“…Sleep disorders such as insomnia, central or obstructive sleep apnea (OSA), RLS, narcolepsy or RBD have all been reported in MS patients [14,15,29]. Our study underscores three important points: (1) sleep disorders are common in MS patients; (2) they are often associated with disability, pain, fatigue and mood disorders leading to impairment of QoL, and (3) subjective assessments of sleep disorders and vigilance in MS patients are often misleading.…”

Section: Discussionmentioning

confidence: 99%

“…Only a few studies have been devoted to sleep disorders associated with MS, although it is well established that patients with MS report sleep disturbances more frequently than the general population and nearly half of the MS patients can be classified as ‘poor sleepers’ [1]. MS patients may be affected by the entire spectrum of sleep disorders (namely insomnia, excessive daytime sleepiness (EDS), periodic leg movements, restless legs syndrome (RLS), abnormal sleep-wake regulation, sleep-disordered breathing, narcolepsy and rapid eye movement (REM) sleep behavior disorder (RBD) [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17] which may have a potentially important impact on overall health and quality of life (QoL) [1]. These sleep disorders can contribute to depression, fatigue, and pain [14].…”

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confidence: 99%

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Sleep Disorders and Multiple Sclerosis: A Clinical and Polysomnography Study

et al. 2012

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Background: Patients with multiple sclerosis (MS) report sleep disturbances (SD) and excessive daytime sleepiness (EDS) more frequently than the general population. Our objectives were to evaluate SD and EDS in MS patients and to test the reliability of subjective sleep questionnaires. Methods: Demographic and clinical characteristics of unselected consecutive patients with MS were collected. Different questionnaires were used to assess quality of sleep, daytime sleepiness, fatigue, anxiety, depression and quality of life (QoL). Nocturnal polysomnography and Multiple Sleep Latency Test (MSLT) were performed in 25 selected MS patients with fatigue and with or without EDS. Results: 205 MS patients were enrolled. More than half of the MS patients were classified as ‘poor sleepers’. In multivariate analysis, SD were correlated with disability, fatigue, depression, QoL, and pain, but not with EDS. Subjective sleepiness evaluated with the Epworth Sleepiness Scale and SD with the Pittsburgh Sleep Quality Index were not correlated with the results of the objective assessments of vigilance (MSLT) and sleep. Conclusions: SD and EDS are frequent among MS patients. Objective assessment of vigilance and sleep can be challenging but MS patients who are poor sleepers should receive immediate assessment and treatment in order to improve QoL.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Sleep Disorders and Multiple Sclerosis: A Clinical and Polysomnography Study

et al. 2012

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“…Treatment of insomnias is pharmacologically based on short-term use of agents such as antihistaminics, benzodiazepines and sedating antidepressants with education on sleep hygiene, relaxation technics and behavioral therapy [70]. Other treatable entities that contribute to sleep problems such as pain, leg cramps and nocturia should be properly managed [62,69].…”

Section: Sleep Disordersmentioning

confidence: 99%

Autonomic dysfunction in multiple sclerosis

Adamec

Habek

2013

Clinical Neurology and Neurosurgery

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“…26 In addition to immunologic abnormalities, MS is associated with an increased prevalence of other conditions contributing to fatigue, including depression and several sleep disorders. 4,27 MS patients, regardless of their level of fatigue, have a significantly high frequency of RLS, higher Epworth Sleepiness Scale scores, and higher Pittsburgh Sleep Quality Index scores. The time in bed, wake time after sleep onset %, total arousal index, limb movement arousal index, and periodic limb movement arousal index were also higher in MS patients than healthy controls.…”

Section: Fatiguementioning

confidence: 97%

“…In either of the two cases, a bidirectional relationship exists between these comorbid conditions. 4 …”

Section: Introductionmentioning

confidence: 99%

Low Prevalence of Sleep Disorders in Demyelinating Disease in a Northern Tenerife Population

González-Platas

González‐Platas

Bermúdez-Hernández

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives: Sleep disorders are seen in patients with demyelinating disease (DD) more often than in the general population. Combination of physical and psychological factors such as pain, spasms, nocturia, depression, anxiety, or medication effects could contribute to sleep disruption. Frequently, these disturbances have a major impact on health and quality of life of patients. The aim of this study was to estimate the prevalence of sleep disorders in patients seen in the DD consultation. Methods: 240 patients; mean age 43 years, 187 women; 163 patients with multiple sclerosis (MS): 144 relapsing-remitting, 19 progressive forms, 36 clinically isolated syndrome, 26 radiological isolated syndrome, and 15 patients with others DD. All participants completed questionnaires: Pittsburgh, Epworth, and Stanford scales, indirect symptoms of RLS and Obstructive Sleep Apnea, Fatigue Severity Scale, and Multiple Sclerosis Quality of Life-54. Results: Moderate/severe insomnia 12.5%, OSA 5.8%, RLS 9.6% (confirmed 3 cases), narcolepsy 0, fatigue (> 4) 24.6%. Physical QoL 66.6 ± 19.6, Mental QoL 66.1 ± 21.9. Patients with an established diagnosis showed higher scores on insomnia compared to the group of CIS and RIS (F = 3.85; p = 0.023), no differences were in the other parameters. Fatigue showed high correlation with insomnia (r = 0.443; p < 0.001), RLS (r = 0.513; p < 0.001), and sleepiness (r = 0.211; p = 0.001). None of the variables included in the regression model were shown to be predictors of Physical and Mental QoL. Conclusions: A high percentage of our sample sleeps well. Emphasize the low prevalence of sleep disorders (insomnia, fatigue, RLS, etc). We detected an overestimation in the RLS questionnaire and the low QoL recorded. I NTRO DUCTI O NMultiple sclerosis (MS) is the main cause of a chronic traumatic disability among young adults (between 20 and 50 years of age) with neurological disorder. MS is an inflammatory autoimmune disease of the central nervous system (CNS) resulting in myelin destruction and axonal degeneration in the brain and spinal cord.Eighty percent of patients present a relapsing-remitting subtype, characterised by clearly defined episodes of neurological dysfunction (relapses) separated by periods of relative clinical stability (remissions). In the majority of untreated cases, relapsing-remitting MS evolves into a secondary-progressive phase during which the subject experiences a gradual, insidious deterioration, usually in the form of paraparesis, hemiparesis, or dementia. A primary-progressive subtype occurs in a smaller percentage of patients, characterised by a slow deterioration in neurologic function from onset, without distinct relapses.The clinical manifestations of MS are provoked by multifocal demyelination and damage to axons in multiple neurological functional systems; these are known as deficit symptoms (or negative symptoms). Other manifestations of MS, such as neuropathic pain and paroxysmal phenomena, are derived from functionally inappropriate axonal responses, which are ...

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Sleep disturbances in multiple sclerosis

Cited by 97 publications

References 71 publications

Sleep Disorders and Multiple Sclerosis: A Clinical and Polysomnography Study

Sleep Disorders and Multiple Sclerosis: A Clinical and Polysomnography Study

Autonomic dysfunction in multiple sclerosis

Low Prevalence of Sleep Disorders in Demyelinating Disease in a Northern Tenerife Population

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