Sleep disturbances: one of the culprits of obesity-related cardiovascular risk?

Muscogiuri, Giovanna; Tuccinardi, Dario; Nicastro, Vincenzo; Barrea, Luigi; Colao, Annamaria; Savastano, Silvia

doi:10.1038/s41367-020-0019-z

Cited by 17 publications

(12 citation statements)

References 103 publications

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“…In agreement with these findings, data coming from the OPERA (Obesity, Programs of nutrition, Education, Research and Assessment of the best treatment) Prevention Project pointed out that individuals with the evening chronotype were, when compared to intermediate and morning chronotypes, more prone to follow an unhealthy lifestyle, performing less regular activity and being more frequent smokers [7,8]. In addition, they showed the lowest adherence to the Mediterranean Diet (MD) compared to the morning and intermediate chronotypes, and the lower their chronotype score, the higher the Body Mass Index (BMI) values in all populations, thus suggesting that the highest chronotype score was more commonly detected in subjects with obesity [9].…”

Section: Introductionmentioning

confidence: 57%

The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?

et al. 2021

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Chronotype is defined as the behavioral manifestation of circadian rhythms related to the external light–dark cycle. Evening chronotype has been associated with an increased risk of developing cardiometabolic diseases in obesity. Menopause is a lifestage associated with an increased risk of developing cardiometabolic diseases and a change in circadian rhythmicity compared to pre-menopause. However, the prevalence of chronotype categories in menopause and their role in determining menopause-related cardiometabolic risk, mostly in obesity, have not been investigated. Thus, we aimed to investigate the prevalence of chronotype categories in post-menopausal women with obesity and their role in menopause-related cardiometabolic risk. In this cross-sectional study we enrolled 49 pre-menopausal and 74 post-menopausal women with obesity. Anthropometric parameters, lifestyle habits, adherence to the Mediterranean Diet (MD), sleep quality, chronotype and the presence of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) were studied. No significance differences were detected in terms of lifestyle and adherence to the MD between pre- and post-menopausal women. Chronotype was classified as morning in 66 (53.6%), evening in 20 (16.3%) and intermediate in 37 (30.1%) women. In addition, pre-menopausal women with obesity showed a significantly higher chance to have an intermediate chronotype (OR = 2.21, 95% CI 1.28–3.83; p = 0.004), whereas post-menopausal women with obesity showed a trend to have a higher morning chronotype (OR = 1.42, 95% CI 0.98–2.06; p = 0.051), although this did not reach statistical significance. No significant differences were detected in terms of prevalence of evening chronotype between the two groups. However, the evening chronotype had a significantly higher risk to have T2DM compared to the morning (OR = 17.29, 95% CI 2.40–124.27; p = 0.005) and intermediate chronotypes (OR = 30.86, 95% CI 2.05–464.32; p = 0.013) in both pre- and post-menopausal women with obesity. In conclusion, the intermediate chronotype was significantly more prevalent in pre-menopausal women with obesity compared to post-menopausal women. Evening chronotype was associated to T2DM in both pre- and post-menopause. These results support the importance of including the assessment of chronotype in the management of women with obesity in post-menopause.

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Section: Introductionmentioning

confidence: 57%

The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?

et al. 2021

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“…Belonging to a chronotype rather than another seems to affect the health profile. In fact, growing evidence suggests that the evening chronotype tends to eat fewer, larger and unwholesome meals [21,48], probably also linked to poor sleep quality [49] or lower self-control levels [21,50]. In particular, there is consolidated evidence linking sleep deprivation, eating times and obesity [51].…”

Section: Discussionmentioning

confidence: 99%

“…The scores ranged from 16 to 86. Individuals, based on their scores, were categorised as being a morning (59-86), neither or intermediate (42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58), or evening (16-41) chronotype.…”

Section: Assessment Of Chronotypementioning

confidence: 99%

Craniopharyngioma, Chronotypes and Metabolic Risk Profile

et al. 2021

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Aim: To investigate the potential association among Craniopharyngioma (CP), chronotypes and metabolic risk profile. Subjects and Methods: The study population included 28 patients (46.4% males; 42.6 ± 15.8 years) and 28 controls, age, gender and BMI matched (46.4% males; 46.5 ± 12.9 years). In this study sample, we evaluated: anthropometric measurements (waist circumference, WC; BMI), plasma glucose, lipid profile, and systolic (SBP) and diastolic (DBP) blood pressure. Morningness-Eveningness was measured with the Horne-Ostberg Morningness-Eveningness Questionnaire (MEQ), which included 19 questions about preferred sleep time and daily performance. Results: in both patients and controls grade I obesity was detected in 15 subjects (53.6%), grade II obesity in 13 subjects (46.4%). In the patient group, the mean score of chronotype was 47.8 ± 12.6. In particular, 9 patients (32.1%) exhibited the morning chronotype, 6 (21.4%) the intermediate chronotype and 13 (46.4.%) the evening chronotype. No significant difference was found in gender and age among the chronotype categories. Patients with the evening chronotype had higher blood pressure values and worse metabolic parameters than those with the morning chronotype. In the control group, the mean score of the chronotype was 57.6 ± 9.5. In particular, 16 (57.1%) subjects exhibited the morning chronotype, 10 (35.7%) the intermediate chronotype and only 2 (7.1.%) the evening chronotype. The prevalence of intermediate and evening chronotypes was higher in females than males (p = 0.021), while males have a higher prevalence of the morning chronotype. Subjects with intermediate and evening chronotypes had worse metabolic parameters than those with the morning chronotype. In patients, the chronotype score was inversely correlated to WC, BMI, SBP, DBP, plasma glucose, total cholesterol, triglycerides, LDL cholesterol and positively correlated with HDL cholesterol. No correlation was found between age and chronotype. In controls, the chronotype score was inversely correlated to WC, BMI, plasma glucose, total cholesterol, LDL cholesterol. No correlation was found among chronotype and age, blood pressure, triglycerides, HDL cholesterol. Considering the whole population of the study (patients and controls), at logistic regression the chronotype score was significantly associated with the presence of CP. Conclusions: for the first time thus far, our study puts the light on the association of the CP with chronotypes and metabolic alterations in this disease, which are the main determinants of the reduced quality of life, higher morbidity and mortality in this setting of patients. This finding suggests that alterations of chronotype might represent an adjunctive risk for CP patients and a possible target for their integrate management.

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“…Therefore, regular practice of exergames has the potential to improve physical fitness and energy expenditure similar to traditional physical exercises [47], which are important mechanisms to improve sleep, as mentioned before. Over long term, exergames might be a useful new strategy to improve physical activity levels and to reduce obesity [48], which can also be important, since obesity [49,50] and sedentary behavior [39] might blunt sleep homeostasis. Here, it is important to note that the dose necessary for obtaining positive results might not be so high, since substituting only 30 min of sedentary behavior by physical activity is sufficient to improve sleep efficiency [39].…”

Section: How Physical Activity Influences Sleep Quality? Let the Exer...mentioning

confidence: 99%

Technology and Sleep Quality: Friend or Foe? Let the Exergames Come into Play!

et al. 2022

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Low sleep quality is associated with many health problems. Although physical exercise is a nonpharmacological tool that positively impacts sleep quality, there are many barriers (lack of energy, lack of motivation, lack of skills, lack of resources, and fear of injury) for people to adopt an active lifestyle. Exergames are an alternative way of physical exercise that are funnier and more attractive than traditional forms of physical exercise and, therefore, has the potential to increase adherence to a physical exercise program. Given that previous studies showed that exergames presents similar physiological and psychological outcomes to traditional forms of exercise, we aimed to discuss in this narrative review potentials applications, limitations and perspectives of using exergames to improve sleep quality.

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Sleep disturbances: one of the culprits of obesity-related cardiovascular risk?

Cited by 17 publications

References 103 publications

The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?

The Importance of Being a ‘Lark’ in Post-Menopausal Women with Obesity: A Ploy to Prevent Type 2 Diabetes Mellitus?

Craniopharyngioma, Chronotypes and Metabolic Risk Profile

Technology and Sleep Quality: Friend or Foe? Let the Exergames Come into Play!

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