2016
DOI: 10.1016/j.cell.2016.04.013
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Sleep Drive Is Encoded by Neural Plastic Changes in a Dedicated Circuit

Abstract: Summary Prolonged wakefulness leads to an increased pressure for sleep, but how this homeostatic drive is generated and subsequently persists is unclear. Here, from a neural circuit screen in Drosophila, we identify a subset of ellipsoid body (EB) neurons whose activation generates sleep drive. Patch-clamp analysis indicates these EB neurons are highly sensitive to sleep loss, switching from spiking to burst-firing modes. Functional imaging and translational profiling experiments reveal that elevated sleep nee… Show more

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Cited by 303 publications
(543 citation statements)
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“…In flies, modulation of glutamatergic synaptic activity in specific neurons, the R2 ring neurons of the ellipsoid body, may be one of the molecular mechanisms by which sleep homeostasis and synaptic plasticity are coupled. Transient activation of R2 neurons using the heat-activated cation channel, TrpA1, induces sleep rebound after activation is relieved with only minimal wake-promoting effects during activation, suggesting that R2 activation can result in persistent sleep drive (Liu et al 2016). Sleep deprivation induces burst firing, intracellular calcium, and the presynaptic protein BRUCHPILOT (BRP) in R2 neurons (Liu et al 2016).…”
Section: Glutamatementioning
confidence: 99%
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“…In flies, modulation of glutamatergic synaptic activity in specific neurons, the R2 ring neurons of the ellipsoid body, may be one of the molecular mechanisms by which sleep homeostasis and synaptic plasticity are coupled. Transient activation of R2 neurons using the heat-activated cation channel, TrpA1, induces sleep rebound after activation is relieved with only minimal wake-promoting effects during activation, suggesting that R2 activation can result in persistent sleep drive (Liu et al 2016). Sleep deprivation induces burst firing, intracellular calcium, and the presynaptic protein BRUCHPILOT (BRP) in R2 neurons (Liu et al 2016).…”
Section: Glutamatementioning
confidence: 99%
“…Transient activation of R2 neurons using the heat-activated cation channel, TrpA1, induces sleep rebound after activation is relieved with only minimal wake-promoting effects during activation, suggesting that R2 activation can result in persistent sleep drive (Liu et al 2016). Sleep deprivation induces burst firing, intracellular calcium, and the presynaptic protein BRUCHPILOT (BRP) in R2 neurons (Liu et al 2016). In addition, sleep deprivation also induced the dNR1 transcript that encodes an NMDA receptor (Liu et al 2016).…”
Section: Glutamatementioning
confidence: 99%
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