Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study

Papantoniou, Kyriaki; Castaño‐Vinyals, Gemma; Espinosa, Ana; Turner, Michelle C.; Martín-Sánchez, Vicente; Casabonne, Delphine; Aragonés, Núria; Gómez‐Acebo, Inés; Ardanáz, Eva; Jiménez-Moleón, José-Juan; Amiano, Pilar; Molina-Barceló, Ana; Alguacil, Juan; Fernández‐Tardón, Guillermo; Huerta, José María; Hernández-Segura, Natalia; Pérez‐Gómez, Beatriz; Llorca, Javier; Vidán-Alli, Juana; Olmedo‐Requena, Rocío; Gil, Leire; Castañón-López, Carmen; Pollán, Marina; Kogevinas, Manolis

doi:10.1038/s41598-021-91275-3

Cited by 23 publications

(28 citation statements)

References 67 publications

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“…A previous study showed that participants without a nap during the day had a 2.03 times higher risk of cancer than those who napped for 1–30 min; however, the frequency and duration of nap have different effects on men, the protective effect of a short nap (1–30 min) on the cancer incidence rate remains unchanged 35 . Papantoniou reported increased rates of gastrointestinal cancer in participants who took longer naps (≥30 min), but reported shorter naps (<30 min) did not increase the risk of gastrointestinal cancer 36 . Naps are not only a way to relieve stress, but also an effective way to deal with sleep debt.…”

Section: Discussionmentioning

confidence: 99%

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Relationships of sleep traits with prostate cancer risk: A prospective study of 213,999 UK Biobank participants

et al. 2022

The Prostate

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Background The effect of sleep on the occurrence of prostate cancer (PCa) remains unclear. This study explored the influence of sleep traits on the incidence of PCa using a UK Biobank cohort study. Methods In this prospective cohort study, 213,999 individuals free of PCa at recruitment from UK Biobank were included. Missing data were imputed using multiple imputation by chained equations. Cox proportional hazards models were used to calculate the adjusted hazard ratios and 95% confidence intervals for PCa (6747 incident cases) across seven sleep traits (sleep duration, chronotype, insomnia, snoring, nap, difficulty to get up in the morning, and daytime sleepiness). In addition, we newly created a healthy sleep quality score according to sleep traits to assess the impact of the overall status of night and daytime sleep on PCa development. E values were used to assess unmeasured confounding. Results We identified 6747 incident cases, of which 344 died from PCa. Participants who usually suffered from insomnia had a higher risk of PCa (hazard ratio [HR]: 1.11; 95% confidence interval [CI]: 1.04–1.19, E value: 1.46). Finding it fairly easy to get up in the morning was also positively associated with PCa (HR: 1.09; 95% CI: 1.04–1.15, E value: 1.40). Usually having a nap was associated with a lower risk of PCa (HR: 0.91; 95% CI: 0.83–0.99, E value: 1.42). Conclusions Fairly easy to get up in the morning and usually experiencing insomnia were associated with an increased incidence of PCa. Moreover, usually having a nap was associated with a lower risk of PCa. Therefore, sleep behaviors are modifiable risk factors that may have a potential impact on PCa risk.

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Section: Discussionmentioning

confidence: 99%

“…35 | 989 risk of gastrointestinal cancer. 36 Naps are not only a way to relieve stress, but also an effective way to deal with sleep debt. In addition, napping can promote the recovery of immune markers, 37,38 which may be beneficial for preventing PCa.…”

Section: Discussionmentioning

confidence: 99%

Relationships of sleep traits with prostate cancer risk: A prospective study of 213,999 UK Biobank participants

et al. 2022

The Prostate

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“…We assessed full-text articles among 38 articles, and then 36 articles were further excluded due to without relevant outcome or exposure. Finally, we identified 18 observational studies that evaluated the association of sleep duration, sleep apnea, or shift work with the risk of colorectal neoplasms (published between 2010 and 2021) (19)(20)(21)(22)(23)(24)(25)(26)(27)(31)(32)(33)36,(38)(39)(40)(41)(42).…”

Section: Study Descriptionmentioning

confidence: 99%

“…The characteristics of the studies, including author, publication year, country, age of participants, gender, followup period, number of participants, exposure details, assessment of outcome, and NOS quality scores, are summarized in Table 1. Of the 18 observational studies, four involved women only (19,22,31,36), one study involved men only (32), and 13 involved both men and women (20,21,(23)(24)(25)(26)(27)33,(38)(39)(40)(41)(42). Furthermore, 11 studies used a cohort study design (19,20,22,23,26,(31)(32)(33)36,38,42), five used a case-control study design (16,21,24,39,41), and two used a nested case-control study (25,27).…”

Section: Study Descriptionmentioning

confidence: 99%

Association of sleep duration, sleep apnea, and shift work with risk of colorectal neoplasms: a systematic review and meta-analysis

Wang¹,

Wang²,

Lin³

et al. 2022

J Gastrointest Oncol

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Background: Although studies have reported that certain sleep characteristics, such as sleep duration and sleep apnea, are linked to the risk of colorectal cancer (CRC), this link remains contentious because of the limited evidence from individual studies. Furthermore, evidence indicated that shift work involving circadian disruption as a probable human carcinogen. This systematic review and meta-analysis aimed to examine the associations between sleep duration, sleep apnea, and shift work with the risk of colorectal neoplasms, including CRC and colorectal adenoma (CRA). Methods:We conducted a comprehensive literature search in PubMed, EMBASE, and Web of Science databases. The inclusion criteria were determined using PICOS principles. Observational studies reporting associations of sleep duration, sleep apnea, or shift work with risk of CRC or CRA were included. We assessed the risk of bias on the basis of the Newcastle-Ottawa Scale.Results: A total of 18 observational studies were included. Of these studies, nine studies reported the effect of sleep duration on risk of colorectal neoplasms, five reported the effect of sleep apnea, and six reported the effect of shift work. The relative risk (RR) for colorectal neoplasms was 1.06 [95% confidence interval (CI): 0.94, 1.20] in the short sleep duration group compared with the moderate sleep duration group. Long sleep duration was associated with an increased risk of colorectal neoplasms (RR: 1.33, 95% CI: 1.07, 1.65). The pooled results showed that sleep apnea was associated with an increased risk of colorectal neoplasms (RR: 1.75, 95% CI: 1.56, 1.97). Furthermore, results showed that the association between shift work and the risk of colorectal neoplasms was not significant (RR: 1.06, 95% CI: 0.95, 1.17). No publication bias was observed in all the analyses (all P>0.05). The sensitivity analysis showed that no individual study substantially influenced the pooled RRs for colorectal neoplasms and CRC.Conclusions: Our findings suggest the significant positive association of long sleep duration and sleep apnea with risk of colorectal neoplasms and CRC. Given that sleep characteristics may be a potentially modifiable risk factor for colorectal neoplasms, further understanding of its role in carcinogenesis will provide valuable insight for cancer prevention.

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“…Circadian rhythm disruption can contribute to suppress melatonin, which is a neurohormone known for its role in hindering cancer initiation and progression (9)(10)(11). Recent studies have demonstrated that circadian disruption might play a role in the etiology of cancers, including colorectal cancer, gastric cancer, prostate cancer, and breast cancer (12,13). However, the mechanisms for the circadian rhythm in cancer are not well elucidated.…”

Section: Introductionmentioning

confidence: 99%

TIMELESS Promotes Tumor Progression by Enhancing Macrophages Recruitment in Ovarian Cancer

Xing

Hua

et al. 2021

Front. Oncol.

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ObjectiveOvarian cancer (OV) is the most fatal and frequent type of gynecological malignancy worldwide. TIMELESS (TIM), as a circadian clock gene, has been found to be highly expressed and predictive of poor prognosis in various cancers. However, the function of TIM in OV is not known. This study was designed to investigate the biological functions and underlying mechanisms of TIM during OV progression.MethodsCell viability assay, cell migration assay, immunohistochemistry staining, qPCR analyses, and tumor xenograft model were used to identify the functions of TIM in OV. Bioinformatics analyses, including GEPIA, cBioPortal, GeneMANIA, and TIMER, were used to analyze the gene expression, genetic alteration, and immune cell infiltration of TIM in OV.ResultsTIM is highly expressed in OV patients. TIM knockdown inhibited OV cell proliferation, migration, and invasion both in vitro and in vivo. Genetic alteration of TIM was identified in patients with OV. TIM co-expression network indicates that TIM had a wide effect on the immune cell infiltration and activation in OV. Further analysis and experimental verification revealed that TIM was positively correlated with macrophages infiltration in OV.ConclusionsOur study unveiled a novel function of highly expressed TIM associated with immune cell especially macrophages infiltration in OV. TIM may serve as a potential prognostic biomarker and immunotherapy target for OV patients.

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Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study

Cited by 23 publications

References 67 publications

Relationships of sleep traits with prostate cancer risk: A prospective study of 213,999 UK Biobank participants

Relationships of sleep traits with prostate cancer risk: A prospective study of 213,999 UK Biobank participants

Association of sleep duration, sleep apnea, and shift work with risk of colorectal neoplasms: a systematic review and meta-analysis

TIMELESS Promotes Tumor Progression by Enhancing Macrophages Recruitment in Ovarian Cancer

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