Sleep Duration and Risk of Liver Cancer in Postmenopausal Women: The Women's Health Initiative Study

Royse, Kathryn E.; El–Serag, Hashem B.; Chen, Liang; White, Donna L.; Hale, Lauren; Sangi‐Haghpeykar, Haleh; Jiao, Li

doi:10.1089/jwh.2017.6412

Cited by 22 publications

(21 citation statements)

References 53 publications

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“…There was also no association between short sleep duration (≤5 hours) and liver cancer risk. Insomnia rating scores, snoring, and daytime napping were also not associated with liver cancer risk (46). In examining survival rates across all cancer sites, no sleep characteristics at WHI baseline (pre-diagnosis) were significantly associated with overall cancer survival.…”

Section: Cancer Health Outcomesmentioning

confidence: 83%

“…Liver cancer risk was higher in obese women with long sleep (46). Among obese WHI participants, those with long sleep duration (≥9 hours) had an increased risk of liver cancer compared to those who slept between 6-8 hours/night.…”

Section: Cancer Health Outcomesmentioning

confidence: 88%

“…Most authors used the WHIIRS questionnaire and the single sleep duration question as their sleep measures. Five articles used sleep duration alone as a primary exposure (43)(44)(45)(46)(47), 2 used the WHIIRS alone (48,49) and 10 articles used both sleep duration and WHIIRS (50)(51)(52)(53)(54)(55)(56)(57)(58)(59). The remaining 6 papers used the snoring item (60), calculated risk score for OSA (42), SDB scale and sleep duration (38), SDB scale and WHIIRS (39), or actigraphy (61,62).…”

Section: Overallmentioning

confidence: 99%

“…Six published papers assessed sleep and cancer outcomes, including breast, thyroid, colorectal, and liver cancer (45,46,(51)(52)(53)(54).…”

Section: Cancer Health Outcomesmentioning

confidence: 99%

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Contributions of the Women's Health Initiative to understanding associations between sleep duration, insomnia symptoms, and sleep-disordered breathing across a range of health outcomes in postmenopausal women

2020

Self Cite

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The Women's Health Initiative (WHI), a longitudinal study of more than 161,000 post-menopausal women across the United States, provides an opportunity to investigate the link between sleep health and healthy aging. The purpose of this paper was to systematically review all published WHI papers investigating sleep as a predictor of health outcomes and health behaviors/quality of life outcomes. A strength of the WHI, is that for most participants, sleep measures were completed before a major health diagnosis, with a significant portion of participants also providing sleep measures after diagnosis. Twenty-three WHI articles were identified and examined for this review. The combination of sleep duration and insomnia symptoms was the most commonly investigated sleep measure. Results indicated that both short (≤6 hours) and long sleep (≥9 hours) duration were associated with a higher risk of cardiovascular disease, colorectal cancer, mortality, cognitive decline, and poor diet. Insomnia symptoms, frequent snoring, and risk of sleep-disordered breathing (SDB) were also associated with increased risk for ischemic stroke and cardiovascular disease. However, many significant results were attenuated after multivariable adjustment. Limitations of these WHI investigations include the use of different categories for sleep measures across studies and a lack of examination by race/ethnicity. Due to the longitudinal study design, large sample size, and long-term follow-up for health outcomes, the WHI serves as a rich resource for examining associations between sleep characteristics, demographics, and health in postmenopausal women.

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Section: Cancer Health Outcomesmentioning

confidence: 83%

Section: Cancer Health Outcomesmentioning

confidence: 88%

Section: Overallmentioning

confidence: 99%

“…Six published papers assessed sleep and cancer outcomes, including breast, thyroid, colorectal, and liver cancer (45,46,(51)(52)(53)(54).…”

Section: Cancer Health Outcomesmentioning

confidence: 99%

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Contributions of the Women's Health Initiative to understanding associations between sleep duration, insomnia symptoms, and sleep-disordered breathing across a range of health outcomes in postmenopausal women

2020

Self Cite

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“…This is likely to contribute to the increased prevalence of many metabolic disorders, cancer, and neurodegenerative diseases in rotating shift workers (50). Moreover, the sleep-wake cycle is a manifestation of circadian rhythms, and sleep shortage is highly associated with NAFLD in woman (51) while long sleep duration was associated with a moderate increase in liver cancer risk in obese postmenopausal women (52). Chronic jet lag induces spontaneous hepatocelluar carinoma in mice (16).…”

Section: Translating Circadian Insights Into Therapeutic Strategiesmentioning

confidence: 99%

Circadian Regulation of Gene Expression and Metabolism in the Liver

Guan

Lazar

2022

Semin Liver Dis

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Circadian rhythms are approximately 24-hour cycles of variation in physiological processes, gene expression, and behavior. They result from the interplay of internal biological clocks with daily environmental rhythms, including light/dark and feeding/fasting. 24-hour rhythms of liver metabolic processes have been known for almost 100 years. Modern studies reveal that, like metabolism, hepatic gene expression is highly rhythmic. Genetic or environmental changes can disrupt the circadian rhythms of the liver, leading to metabolic disorders and hepatocellular carcinoma. In this review, we summarize the current understanding of mechanisms regulating rhythmic gene expression in liver, highlighting the roles of transcription factors that comprise the core clock molecular as well as noncanonical regulators. We emphasize the plasticity of circadian rhythms in the liver as it responds to multiple inputs from the external and internal environments as well as the potential of circadian medicine to impact liver-related diseases.

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Prevalence of poor sleep quality during menopause: a meta-analysis

Jia,

Zhou,

Cao

2024

Sleep Breath

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Sleep Duration and Risk of Liver Cancer in Postmenopausal Women: The Women's Health Initiative Study

Abstract: Long sleep duration was associated with a moderate increase in liver cancer risk in obese postmenopausal women in the United States. Larger study is needed to confirm our observation on effect modification by adiposity status.

Cited by 22 publications

References 53 publications

Contributions of the Women's Health Initiative to understanding associations between sleep duration, insomnia symptoms, and sleep-disordered breathing across a range of health outcomes in postmenopausal women

Contributions of the Women's Health Initiative to understanding associations between sleep duration, insomnia symptoms, and sleep-disordered breathing across a range of health outcomes in postmenopausal women

Circadian Regulation of Gene Expression and Metabolism in the Liver

Prevalence of poor sleep quality during menopause: a meta-analysis

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