Sleep duration and risk of fatal and nonfatal stroke

Abstract

Objective:To study the association between sleep duration and stroke incidence in a British population and to synthesize our findings with published results through a meta-analysis.Methods:The prospective study included 9,692 stroke-free participants aged 42–81 years from the European Prospective Investigation into Cancer–Norfolk cohort. Participants reported sleep duration in 1998–2000 and 2002–2004, and all stroke cases were recorded until March 31, 2009. For the meta-analysis, we searched Ovid Medline, EMBASE, and the Cochrane Library for prospective studies published until May 2014, and pooled effect estimates using a weighted random-effect model.Results:After 9.5 years of follow-up, 346 cases of stroke occurred. Long sleep was significantly associated with an increased risk of stroke (hazard ratio [HR] = 1.46 [95% confidence interval (CI) 1.08, 1.98]) after adjustment for all covariates. The association remained robust among those without preexisting diseases and those who reported sleeping well. The association for short sleep was smaller (and not statistically significant) (HR = 1.18 [95% CI 0.91, 1.53]). There was a higher stroke risk among those who reported persistently long sleep or a substantial increase in sleep duration over time, compared to those reporting persistently average sleep. These were compatible with the pooled HRs from an updated meta-analysis, which were 1.15 (1.07, 1.24) and 1.45 (1.30, 1.62) for short and long sleep duration, respectively.Conclusions:This prospective study and meta-analysis identified prolonged sleep as a potentially useful marker of increased future stroke risk in an apparently healthy aging population.

Self‐Reported Sleep Duration and Quality and Cardiovascular Disease and Mortality: A Dose‐Response Meta‐Analysis

“…A total of 74 studies met the inclusion criteria; the process of study selection is shown in Figure 1 8, 9, 11, 12, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89,...…”

“…Whereas sleep duration is generally not considered a traditional risk factor for cardiovascular disease (CVD), growing evidence supports its association with cardiovascular risk (CVR) factors2, 3, 4, 5, 6, 7 and disease,8, 9, 10, 11 and quality of sleep appears to contribute to CVR 10, 12. Yet, current guidelines for the risk reduction of CVD make limited recommendations about quality or duration of sleep 13, 14…”

Sleep Duration and Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos

“…25 Long sleep duration is also associated with cerebrovascular disease, increased brain white-matter hyperintensities and stroke; factors linked to worse neurocognitive outcomes. [38][39][40] It is plausible that cerebrovascular damage associated with long sleep, affects white matter tracts and inter-connections between cortical areas and subcortical structures, resulting in neurocognitive dysfunction. 41,42 This work represents an important advance in understanding sleep duration and neurocognitive function in a representative sample of middle-aged and older Hispanic/Latino adults from diverse backgrounds.…”

Sleep Disorders in the Early Recovery Period of Cerebral Stroke and the Possibility of Chronotherapeutical Correction

“…На сегодняшний день установлено, что расстройства сна не просто служат одним из наиболее характерных проявлений десинхроноза и маркером нарушений про-цессов адаптации, но и в подавляющем большинстве случаев сопряжены с нарушениями аффективной и ког-нитивной сферы [8][9][10].…”