Sleep duration and risk of cancer incidence and mortality: A pooled analysis of six population‐based cohorts in Japan

Abstract

Sleep duration is emerging as an important modifiable risk factor for morbidity and mortality. We assessed the association between sleep duration and cancer incidence and mortality among Japanese adults using data from six population‐based cohorts with 271 694 participants. During a total follow‐up period of about 5.9 million person‐years, we identified 40 751 incident cancer cases and 18 323 cancer deaths. We computed study‐specific hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression models and pooled the estimates using random‐effects meta‐analysis. Sleep duration of ≥10 hours (vs 7 hours) was associated with increased risk of cancer incidence among women (HR 1.19, 95% CI 1.02‐1.38), but not men, and increased risk of cancer mortality among men (HR 1.18, 95% CI 1.00‐1.39) and women (HR 1.44, 95% CI 1.20‐1.73). Sleep duration of ≤5 hours (vs 7 hours) was not associated with cancer incidence and mortality. However, among postmenopausal women, sleep durations of both ≤5 and ≥10 hours (vs 7 hours) were associated with an increased risk of cancer mortality. Among Japanese adults, sleep duration of ≥10 hours is associated with increased risk of cancer incidence and mortality among women and cancer mortality among men.

Association of habitual sleep duration and its trajectory with the risk of cancer according to sex and body mass index in a population‐based cohort

“…29 Similarly, a pooled analysis of six population-based cohorts in Japan indicated that long sleepers with BMI <24 kg/m 2 had elevated risk of cancer incidence. 30 Although the above results are contrary to our findings, they indicate that stratification by sex and BMI revealed variations in the risk of cancer incidence.…”

“…However, sleep duration was associated with certain types of cancer, which varied by sex 28 . Some studies have also indicated that long sleep duration is related to a high risk of cancer 29,30 . A United Kingdom Biobank study found that long sleep duration (≥9 vs. 7 h) was associated with an increased risk of cancer incidence in men, but no association was found with short sleep duration 29 .…”

“…A United Kingdom Biobank study found that long sleep duration (≥9 vs. 7 h) was associated with an increased risk of cancer incidence in men, but no association was found with short sleep duration 29 . Similarly, a pooled analysis of six population‐based cohorts in Japan indicated that long sleepers with BMI <24 kg/m 2 had elevated risk of cancer incidence 30 . Although the above results are contrary to our findings, they indicate that stratification by sex and BMI revealed variations in the risk of cancer incidence.…”

“…28 Some studies have also indicated that long sleep duration is related to a high risk of cancer. 29,30 A United Kingdom Biobank study found that long sleep duration (≥9 vs. 7 h) was associated with an increased risk of cancer incidence in men, but no association was found with short sleep duration. 29 Similarly, a pooled analysis of six population-based cohorts in Japan indicated that long sleepers with BMI <24 kg/m 2 had elevated risk of cancer incidence.…”

Meeting 24-h movement guidelines and markers of adiposity in adults from eight Latin America countries: the ELANS study

“…Particularly Latin American women seem to lag behind in MVPA compared with men in international research 24 , 29 , 48 . Increasing MVPA levels and sleep duration would be favorable for the population 49 , 50 and would also increase the proportion of Latin American adults meeting the integrated 24-h movement recommendations. Intervention and public health promotion efforts to inspire MVPA and adequate sleep time, which enhance compliance with the 24-h movement guideline recommendations are essential in this group.…”