Sleep duration and sarcopenia risk: a systematic review and dose-response meta-analysis

Pourmotabbed, Ali; Ghaedi, Ehsan; Babaei, Atefeh; Mohammadi, Hamed; Khazaie, Habibolah; Jalili, Cyrus; Symonds, Michael; Moradi, Sajjad; Miraghajani, Maryam

doi:10.1007/s11325-019-01965-6

Cited by 52 publications

(51 citation statements)

References 63 publications

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“…Other studies among middle‐aged and older adults showed that only long sleep duration was cross‐sectionally associated with sarcopenia 14,15 . Moreover, a meta‐analysis revealed a U‐shaped association between sleep duration and the risk of sarcopenia, although short sleep duration was not associated with it among men 16 . The results of that meta‐analysis were calculated from a small number of cross‐sectional studies, so the association between sleep duration and sarcopenia has remained controversial.…”

Section: Discussionmentioning

confidence: 93%

“… 14 , 15 Moreover, a meta‐analysis revealed a U‐shaped association between sleep duration and the risk of sarcopenia, although short sleep duration was not associated with it among men. 16 The results of that meta‐analysis were calculated from a small number of cross‐sectional studies, so the association between sleep duration and sarcopenia has remained controversial. This is the first study to examine the temporal association between long sleep duration and sarcopenia using longitudinal cohort data, although it was not possible to examine the association according to sex because of the small number of cases that progressed to sarcopenia during the follow‐up period.…”

Section: Discussionmentioning

confidence: 99%

“… 11 In addition, several previous studies demonstrated that sleep duration was associated with skeletal muscle loss or sarcopenia. 12 , 13 , 14 , 15 Although a systematic review showed the U‐shaped association of sleep duration and the risk of sarcopenia, 16 the studies used in this meta‐analysis were cross‐sectional in nature, not longitudinal. Therefore, additional evidence is needed to reveal the association between sleep duration and sarcopenia, especially from a longitudinal study.…”

Section: Introductionmentioning

confidence: 99%

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Sleep duration and progression to sarcopenia in Japanese community‐dwelling older adults: a 4 year longitudinal study

Nakakubo

Doi

Tsutsumimoto

et al. 2021

J cachexia sarcopenia muscle

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Background Identifying factors that contribute to the development of sarcopenia in older adults is a public health priority. Although several studies have examined the association between sleep duration and sarcopenia, additional evidence is needed to reveal the causality of this association, especially from a longitudinal study. The purpose of the present study was to examine whether sleep duration was associated with the progression to sarcopenia and its subcomponents among community‐dwelling older adults in Japan. Methods A total of 3918 older community‐dwelling people (mean age: 73.2 ± 6.0 years, 51.8% female) included in the National Center for Geriatrics and Gerontology Study of Geriatric Syndromes were analysed. Sleep duration was assessed using a self‐reported questionnaire. Logistic regression analysis was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of progression of sarcopenia at Wave 2 (4 years later), according to the three categories of sleep duration [short: ≤6.0 h, medium: 6.1–8.9 h (control), & long: ≥9.0 h)] at Wave 1. Results The numbers in each group in the second wave among the total sample were as follows: short 403 (10.3%), medium 2877 (73.4%), and long 638 (16.3%). Significant associations with the progression of sarcopenia were found in the long sleep duration group compared with the medium one, even after adjustment for other covariates (OR 1.66, 95% CI: 1.02–2.69, P = 0.040). Long sleep duration was significantly associated with slow gait (OR: 1.55, 95% CI: 1.17–2.06, P = 0.002) and low grip strength (OR: 1.34, 95% CI: 1.00–1.78, P = 0.047) but was not associated with low muscle mass (OR: 1.33, 95% CI: 0.74–2.38, P = 0.343). Conclusions This study revealed that long sleep duration was associated with an increased risk of progression to sarcopenia among older adults.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sleep duration and progression to sarcopenia in Japanese community‐dwelling older adults: a 4 year longitudinal study

Nakakubo

Doi

Tsutsumimoto

et al. 2021

J cachexia sarcopenia muscle

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“…Shortened and fragmented sleep may affect food cravings 21 and appetite regulation through gut-brain axis disruption, which may alter energy balance 22 and lead to weight gain 23 . Additionally, sleep restriction may interfere with steroid hormone production 24,25 , increasing muscle mass and strength declines [26][27][28] and enhance sarcopenia risk 29 . The aim of this narrative review is to highlight the physiological impact of sleep restriction through randomized controlled and crossover studies, focusing on how hypothalamic and steroid hormone dysfunction may impair adipose tissue and skeletal muscle, and increase the risk of obesity and sarcopenia.…”

Section: Jfsf 51mentioning

confidence: 99%

Effects of sleep deprivation on sarcopenia and obesity: A narrative review of randomized controlled and crossover trials

Prokopidis¹,

Dionyssiotis²

2021

JFSF

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Risk of sarcopenia and obesity are driven by multiple parameters, including chronic pro-inflammatory cytokine secretion, increased oxidative stress, physical inactivity, malnutrition 12 , and sleep disorders 13 . Modern societies have established an association between metabolic disorders and chronic sleep deprivation 14 through excessive blue-light exposure from social media and computer screening, late social activities, and shift work [15][16][17] . Considering that older individuals are at great risk of obstructive sleep apnea, restless legs syndrome, anxiety disorders, dementia, and psychostimulants, which may trigger insomnia and further disturb sleeping patterns 18,19 , sleep disorders may be Abstract Shortened and fragmented sleeping patterns occupying modern industrialized societies may promote metabolic disturbances accompanied by increased risk of weight gain and skeletal muscle degradation. Short-term sleep restriction may alter energy homeostasis by modifying dopamine brain receptor signaling, leading to hyperpalatable food consumption and risk of increased adiposity. Concomitantly, the metabolic damage caused by lower testosterone and higher cortisol levels may stimulate systemic inflammation, insulin resistance, and suppress pathways involved in muscle protein synthesis. These changes may lead to dysregulated energy balance and skeletal muscle metabolism, increasing the risk of sarcopenic obesity, an additional public health burden. Future trials controlling for food intake and exploring further the influence of sleep deprivation on anabolic and catabolic signaling, and gut peptide interaction with energy balance are warranted.

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“…Different risk factors are involved in the age-related changes characterizing sarcopenia. These include genetic factors, gender, ethnical background, socioeconomic status, as well as modifiable factors such as low physical activity, poor diet [13][14][15], and sleep disturbance [16,17], while the effects of alcohol consumption and cigarette smoking are not clear [18][19][20]. Comorbidities and pharmacological intervention might further contribute to sarcopenia in the elderly [14,15].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Glucose-Lowering Drugs on Sarcopenia in Type 2 Diabetes: Current Evidence and Underlying Mechanisms

Massimino

Izzo

Riccardi

et al. 2021

Cells

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The age-related decrease in skeletal muscle mass together with the loss of muscle power and function is defined sarcopenia. Mounting evidence suggests that the prevalence of sarcopenia is higher in patients with type 2 diabetes mellitus (T2DM), and different mechanisms may be responsible for this association such as impaired insulin sensitivity, chronic hyperglycemia, advanced glycosylation end products, subclinical inflammation, microvascular and macrovascular complications. Glucose-lowering drugs prescribed for patients with T2DM might impact on these mechanisms leading to harmful or beneficial effect on skeletal muscle. Importantly, beyond their glucose-lowering effects, glucose-lowering drugs may affect per se the equilibrium between protein anabolism and catabolism through several mechanisms involved in skeletal muscle physiology, contributing to sarcopenia. The aim of this narrative review is to provide an update on the effects of glucose-lowering drugs on sarcopenia in individuals with T2DM, focusing on the parameters used to define sarcopenia: muscle strength (evaluated by handgrip strength), muscle quantity/quality (evaluated by appendicular lean mass or skeletal muscle mass and their indexes), and physical performance (evaluated by gait speed or short physical performance battery). Furthermore, we also describe the plausible mechanisms by which glucose-lowering drugs may impact on sarcopenia.

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Sleep duration and sarcopenia risk: a systematic review and dose-response meta-analysis

Cited by 52 publications

References 63 publications

Sleep duration and progression to sarcopenia in Japanese community‐dwelling older adults: a 4 year longitudinal study

Sleep duration and progression to sarcopenia in Japanese community‐dwelling older adults: a 4 year longitudinal study

Effects of sleep deprivation on sarcopenia and obesity: A narrative review of randomized controlled and crossover trials

The Impact of Glucose-Lowering Drugs on Sarcopenia in Type 2 Diabetes: Current Evidence and Underlying Mechanisms

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