Sleep Duration, Lipid Profile and Insulin Resistance: Potential Role of Lipoprotein(a)

Abstract

<jats:p>Lipoprotein (a) (Lp(a)) is considered a genetic factor for cardiovascular disease playing an important role in atherogenesis and thrombosis, but the evidence about its association with sleep duration is controversial. We evaluated the relation between self-reported sleep duration and Lp(a). Among 1600 participants of the population-based sample, we selected 1427 subjects without previously known cardiovascular events, who answered the questions about their sleep duration; had valid lipid profile results (total cholesterol, low- and high-density lipoproteins, Lp(a), apolipoprotein AI (ApoAI), ApoB, and ApoB/ApoAI); and did not take lipid-lowering drugs (mean age 46 ± 12 years). We performed a structured interview, which included questions about lifestyle, medical history, complaints, and sleep duration (How long have you been sleeping per night during the last month?). Sleep duration was classified as follows: &lt;6 h/night—short, 6–9 h/night—normal, and ≥10 h/night—long. Overall, 73 respondents (5.2%) were short-sleepers and 69 (4.8%) long-sleepers. Males were slightly more prevalent among short-sleepers. The groups matched by age, body mass index, blood pressure, diabetes mellitus, and hypertension rate. Short-sleepers had lower rates of high total cholesterol (≥5.0 mmol/L), lower Lp(a) levels and lower rates of increased Lp(a) ≥0.5 g/L, and higher insulin and insulin resistance (assessed by the homeostatic model assessment for insulin resistance (HOMA-IR)). ApoAI, ApoB, their ratio, and other lab tests were similar in the groups. The multinomial logistic regression demonstrated that only the short sleep duration was independently (odds ratio (OR) 0.29, 95% confidence interval (CI) (0.09–0.91), p = 0.033) associated with Lp(a) (χ2 = 41.58, p = 0.003). Other influencing factors were smoking and HOMA-IR. Such an association was not found for long-sleepers. In conclusion, a short-sleep duration is associated with Lp(a). The latter might mediate the higher insulin resistance and higher cardiometabolic risks in short-sleepers.</jats:p>

Physical Activity Is Associated With Sleep Quality: Results of the ESSE-RF Epidemiological Study

“…Sleep quality was assessed based on five questions regarding sleep duration and sleep problems (described in Korostovtseva et al, 2020 ) ( Supplementary Table 1 ).…”

“…Sleep quality was assessed based on five questions regarding sleep duration and sleep problems (described in Korostovtseva et al, 2020) In accordance with the European guideline for the diagnosis and treatment of insomnia (Riemann et al, 2017) difficulty falling asleep, maintaining sleep, uncontrolled daytime falling asleep three and more times a week were considered as sleep problems.…”

Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study

“…Totally 4,394 participants were excluded. We applied the classification of sleep duration proposed by the National Sleep Foundation [23,24], sleep duration was categorized into short sleep duration (< 6 h/night), normal sleep duration (6-9 h/night), and long sleep duration (> 9 h/night).…”

Health problems associated with single, multiple, and the frequency of months of objectively measured long working hours: a cohort study by the National Institute of Occupational Safety and Health, Japan

“…Another prospective study found that middle-aged men whose workload had increased during the year preceding the study period had increased LDL cholesterol levels (Siegrist et al 1998 ). Apart from psychosocial factors, sleep problems, such as short or poor sleep due to long working hours, may be related to the occurrence of dyslipidemia (Korostovtseva et al 2020 ; Keovanini et al 2020). However, the currently available evidence does not support the possibility of a specific association between sleep problems and high LDL cholesterol levels (Kruisbrink et al 2017 ; Abdurahman et al 2020 ).…”