Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia

Gordijn, Maartje S.; Litsenburg, Raphaële R. van; Gemke, Reinoud J. B. J.; Huisman, J.; Bierings, Marc; Hoogerbrugge, Peter M.; Kaspers, Gertjan J. L.

doi:10.1002/pbc.24261

Cited by 98 publications

(117 citation statements)

References 43 publications

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“…Parent-proxy report of symptoms in adolescents is known to differ significantly from adolescent self-report. In a study of acute lymphoblastic leukemia (ALL) survivors, Gordijn et al (2013) found that parent-reported sleep disturbance was significantly related to increased depressive symptoms and poor quality of life per parents' report; however, ALL survivors reported better sleep quality and fewer depressive symptoms than their healthy peers. These conflicting subjective reports indicated the need for further study in this population using validated surveys.…”

Section: Discussionmentioning

confidence: 96%

“…Although these studies provide valuable information on the nature of sleep in this patient population, findings cannot be generalized to the broader population of survivors of childhood cancer because the etiology of sleep disturbance in survivors of CNS tumors may differ from that of other cancer survivors. To date, only one other study explored associations between reported sleep problems and negative sequelae associated with impaired sleep in an adolescent survivor population (Gordijn et al, 2013).…”

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confidence: 99%

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Self-Reported Sleep Problems in Adolescent Survivors of Childhood Cancer

Desaulniers¹,

Riley²,

Vangle³

et al. 2015

CJON

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Sleep problems were reported before treatment (6%), during treatment (18%), after treatment (15%), and at present (11%). ASCC reporting sleep problems reported more adverse psychosocial outcomes than those without. Significant associations (p ≤ 0.05) between sleep problems and difficulty in school were identified at all time points. Sleep problems were associated with depressive symptoms, memory problems, and anxiety during and after treatment and at present.

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Self-Reported Sleep Problems in Adolescent Survivors of Childhood Cancer

Desaulniers¹,

Riley²,

Vangle³

et al. 2015

CJON

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“…Studies including AYA have done so as part of a larger age range (either childhood or adulthood) without specific subgroup analyses. Such research has described higher instances of disrupted sleep among survivors ages 5–17 relative to norms [11], sleep disturbances in 49 % of acute lymphoblastic leukemia survivors ages 18–41 [3], and sleep efficiency (percentage of time in bed asleep) below 85 % suggestive of insomnia in almost one third of 20–48-year-old survivors [12]. The Childhood Cancer Survivor Study (ages 18–50+) found slightly higher rates of sleep disturbances (16 %) in survivors relative to siblings (12 %) and that survivors were 1.9 times more likely to be fatigued than sibling controls [13].…”

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confidence: 99%

Relationship between sleep problems and psychological outcomes in adolescent and young adult cancer survivors and controls

Daniel

Kazak

et al. 2015

Support Care Cancer

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Purpose How cancer history and distress relate to sleep outcomes of adolescents and young adults (AYAs) is unclear. The current study compares AYA cancer survivors to controls on indicators of sleep and fatigue; examines the concurrent association between psychological status, sleep, and fatigue; and investigates the lagged relationship between sleep and fatigue problems with psychological functioning. Methods AYA cancer survivors (n=167) and controls (n= 170), ages 16 to 30, completed measures at a survivorship clinic/primary care visit (time 1) and 2 months later (time 2). Participants completed questions about sleep quality, quantity, sleep medication use, self-reports of sleep problems, and fatigue in addition to measures of depression, anxiety, and post-traumatic stress symptoms (PTSS). Results There were no differences in sleep quantity or quality between survivors and controls, but survivors reported significantly more fatigue. Within groups, AYAs with self-reported sleep and fatigue problems reported significantly higher depression, anxiety, and PTS symptoms. Controlling for baseline depression, sleep, and fatigue problems at time 1 significantly predicted depression at time 2 in survivors but not in controls. Conclusion This study offers important insight into the psychological functioning of childhood cancer survivors and prospectively describes sleep and fatigue as risk factors for poor psychological functioning in survivors. These findings support screening for sleep problems in AYA survivors as these difficulties are closely related to mental health functioning.

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“…During treatment, the child is isolated from his/her school, friends, and family members. All these factors impair the quality of life of the children and their families and induce psychological problems (7)(8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

A prospective follow-up of quality of life, depression, andanxiety in children with lymphoma and solid tumors

Yildirim¹,

Demirkaya²,

Sevinir³

et al. 2017

Turk J Med Sci

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The aim of this study was the determination and prospective follow-up of quality of life, depression, and anxiety in pediatric patients with cancer under chemotherapy, as well as the evaluation of related factors.Materials and methods: Fifty newly diagnosed pediatric cancer patients and their parents were prospectively monitored before, during, and after therapy, and tests were used.Results: Significantly lower quality of life scores were recorded during treatment, in the group with CNS tumors, in the group receiving chemotherapy plus radiotherapy plus surgery, in the inpatient-only treatment group, in the group receiving treatment for longer than 6 months, and in the group of patients whose diagnosis was delayed for more than 3 months. Total quality of life scores for children and their parents were 82.

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Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia

Abstract: Differences in parental and self-reports, including worse parental ratings, might be explained by worried parents and/or the adaptive style of the children. Impaired sleep and fatigue correlated with more depressive symptoms and a worse QoL.

Cited by 98 publications

References 43 publications

Self-Reported Sleep Problems in Adolescent Survivors of Childhood Cancer

Self-Reported Sleep Problems in Adolescent Survivors of Childhood Cancer

Relationship between sleep problems and psychological outcomes in adolescent and young adult cancer survivors and controls

A prospective follow-up of quality of life, depression, andanxiety in children with lymphoma and solid tumors

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