Sleep Hungry for Cellular Cleanup!

Abstract

Enhanced autophagy during night/fasting phase has a key modulator for health and life span extension. Compared with flies in ad libitum control group, the flies in 20 h of night/fasting (iTRF, intermittent time-restricted feeding) group exhibits significantly elevated beneficial impacts on healthspan and lifespan through upregulated autophagy activity during night/fasting phase.

“A broken heart” becomes sleepless, literally

“…Attaining sufficient sleep at the right times is essential for survival and proper maintenance of healthy bodies and minds. The sleep-wake cycle is tightly controlled by the hormone melatonin, which is produced and secreted by the pineal gland in the brain in response to darkness and is tightly associated with the expression of circadian clock genes ( Huh, 2022 , Lynch et al, 1975 ). Therefore, its level is high at night but low during the day.…”