Sleep in Older Adults With Alzheimer's Disease

Song, Yeonsu; Dowling, Glenna A.; Wallhagen, Margaret; Lee, Kathryn A.; Strawbridge, William J.

doi:10.1097/jnn.0b013e3181e26b1d

Cited by 27 publications

(26 citation statements)

References 83 publications

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“…Its therapeutic applications are numerous, from pediatric [49,50,51] to geriatric diseases [52,53,54]; this includes cancer [55,56], sleep disturbances [57,58] and neurodegenerative diseases [59,60]. …”

Section: Why Melatonin?mentioning

confidence: 99%

Melatonin as a Potential Agent in the Treatment of Sarcopenia

Coto‐Montes

Boga

Tan

et al. 2016

IJMS

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Considering the increased speed at which the world population is aging, sarcopenia could become an epidemic in this century. This condition currently has no means of prevention or treatment. Melatonin is a highly effective and ubiquitously acting antioxidant and free radical scavenger that is normally produced in all organisms. This molecule has been implicated in a huge number of biological processes, from anticonvulsant properties in children to protective effects on the lung in chronic obstructive pulmonary disease. In this review, we summarize the data which suggest that melatonin may be beneficial in attenuating, reducing or preventing each of the symptoms that characterize sarcopenia. The findings are not limited to sarcopenia, but also apply to osteoporosis-related sarcopenia and to age-related neuromuscular junction dysfunction. Since melatonin has a high safety profile and is drastically reduced in advanced age, its potential utility in the treatment of sarcopenic patients and related dysfunctions should be considered.

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Section: Why Melatonin?mentioning

confidence: 99%

Melatonin as a Potential Agent in the Treatment of Sarcopenia

Coto‐Montes

Boga

Tan

et al. 2016

IJMS

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“…Sleep represents a series of well-defined and behaviorally relevant transitions in neural state that are stable across normal human sleepers while showing distinct changes across the lifespan (Campbell and Murphy, 2007; Gertner et al, 2002; Munch et al, 2010; Terry et al, 2004) and in many neuropathologies (Claassen et al, 2010; Moller et al, 2009; Song et al, 2010; Walters et al, 2008). While a number of studies have examined network correlates of stable NREM (Braun et al, 1997; Czisch et al, 2004; Dang-Vu et al, 2005, 2008; Horovitz et al, 2008, 2009; Kaufmann et al, 2006; Larson-Prior et al, 2009; Nofzinger et al, 2002; Spoormaker et al, 2010) and REM (Braun et al, 1997; He et al, 2008; Magnin et al, 2004; Maquet et al, 1996, 2005; Wehrle et al, 2005, 2007) sleep, far fewer have examined those of the initial transitional stage of sleep (N1; Corsi-Cabrera et al, 2006; Jann et al, 2009; Kjaer et al, 2002; Laufs et al, 2006; Olbrich et al, 2009; Picchioni et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Modulation of the brain’s functional network architecture in the transition from wake to sleep

Larson‐Prior

Power

Vincent

et al. 2011

Slow Brain Oscillations of Sleep, Resting State and Vigilance

126

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The transition from quiet wakeful rest to sleep represents a period over which attention to the external environment fades. Neuroimaging methodologies have provided much information on the shift in neural activity patterns in sleep, but the dynamic restructuring of human brain networks in the transitional period from wake to sleep remains poorly understood. Analysis of electrophysiological measures and functional network connectivity of these early transitional states shows subtle shifts in network architecture that are consistent with reduced external attentiveness and increased internal and self-referential processing. Further, descent to sleep is accompanied by the loss of connectivity in anterior and posterior portions of the default-mode network and more locally organized global network architecture. These data clarify the complex and dynamic nature of the transitional period between wake and sleep and suggest the need for more studies investigating the dynamics of these processes.

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“…Residents with dementia experience excessive daytime sleepiness, and at night, difficulty falling asleep, increased duration and frequency of awakenings, and disrupted sleep-wake rhythms (Rose & Lorenz, 2010; Song, Dowling, Wallhagen, Lee, & Strawbridge, 2010). Ancoli-Israel et al (1989) have shown that residents with dementia were not totally awake or fully asleep in a single hour during a 24-hr period, and these residents with dementia, on average, fell asleep 22 times for a total of 2 hr during the daytime (Ancoli-Israel, Parker, Sinaee, Fell, & Kripke, 1989).…”

mentioning

confidence: 99%

Person-Centered Dementia Care and Sleep in Assisted Living Residents With Dementia: A Pilot Study

Grandner

Chang

et al. 2015

Behavioral Sleep Medicine

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The sleep of people with dementia living in long-term care is known to be disturbed. This pre–post controlled pilot study examined the effects of a person-centered dementia care intervention on sleep in assisted living residents with dementia. The three-month intervention included in-class staff training plus supervision and support in practice. The sleep-wake patterns were measured using actigraphy for three consecutive days at baseline and postintervention. Sixteen residents from the intervention and six from the control groups completed the study. The intervention group had significantly more nighttime sleep at posttest. After adjusting for baseline, the intervention group exhibited significantly less daytime sleep and more nighttime sleep. Person-centered dementia care may be effective for improving sleep of residents with dementia.

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Sleep in Older Adults With Alzheimer's Disease

Cited by 27 publications

References 83 publications

Melatonin as a Potential Agent in the Treatment of Sarcopenia

Melatonin as a Potential Agent in the Treatment of Sarcopenia

Modulation of the brain’s functional network architecture in the transition from wake to sleep

Person-Centered Dementia Care and Sleep in Assisted Living Residents With Dementia: A Pilot Study

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