Sleep in Parkinson’s Disease with Impulse Control Disorder

Figorilli, Michela; Congiu, Patrizia; Lecca, Rosamaria; Gioi, Gioia; Frau, Roberto; Puligheddu, Monica

doi:10.1007/s11910-018-0875-x

Cited by 9 publications

(6 citation statements)

References 124 publications

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“…Moreover, it is believed that ICDs and LID share epigenetic and genetic mechanisms such as Ser9Gly gene polymorphism that codes D3 receptor, or higher expression of transcriptional regulator ΔFosB [ 49 , 50 ]. We have found out that ICD patients are more likely to have sleep disorders (including insomnia, hypersomnia, and REM sleep behavior disorder) compared to non-ICD patients, which is in accordance with previous analyses [ 51 , 52 ]; however, the mechanism of this correlation remains unknown and requires further research [ 53 ]. In our study group, no correlation between the intensity of depression and ICDs occurrence was shown, which is not consistent with results obtained by other researchers [ 54 ].…”

Section: Discussionsupporting

confidence: 91%

Impulse Control Disorders in the Polish Population of Patients with Parkinson’s Disease

Toś

Grażyńska

Antoniuk³

et al. 2023

Medicina

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Background and Objectives: Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in the world. It is characterized by the presence of not only typical motor symptoms but also several less known and aware non-motor symptoms (NMS). The group of disorders included in the NMS is Impulse Control Disorders (ICDs). ICDs are a group of disorders in which patients are unable to resist temptations and feel a strong, pressing desire for specific activities such as gambling, hypersexuality, binge eating, and compulsive buying. The occurrence of ICDs is believed to be associated primarily with dopaminergic treatment, with the use of dopamine agonists (DA), and to a lesser extent with high doses of L-dopa. The aim of our study was to develop a profile of Polish ICDs patients and assess the frequency of occurrence of ICDs, as well as determine the risk factors associated with these disorders against the background of the PD population from other countries. Materials and Methods: Our prospective study included 135 patients with idiopathic PD who were hospitalized between 2020 and 2022 at the Neurological Department of University Central Hospital in Katowice. In the assessment of ICDs, we used the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease (QUIP). Other scales with which we assessed patients with PD were as follows: MDS-UPDRS part III and modified Hoehn–Yahr staging. Clinical data on age, gender, disease duration and onset, motor complications, and medications were collected from electronic records. Results: ICDs were detected in 27.41% of PD patients (binge eating in 12.59%, hypersexuality in 11.11%, compulsive buying in 10.37%, and pathological gambling occurred in only 5.19% of patients. In total, 8.89% had two or more ICDs). The major finding was that ICDs were more common in patients taking DA than in those who did not use medication from this group (83.78% vs. 54.07%, respectively; p = 0.0015). Patients with ICDs had longer disease duration, the presence of motor complications, and sleep disorders. An important finding was also a very low detection of ICDs in a routine medical examination; only 13.51% of all patients with ICDs had a positive medical history of this disorder. Conclusions: ICDs are relatively common in the population of Polish PD patients. The risk factors for developing ICDs include longer duration of the disease, presence of motor complications, sleep disorders, and use of DA and L-dopa. Due to the low detectability of ICDs in routine medical history, it is essential for physicians to pay more attention to the possibility of the occurrence of these symptoms, especially in patients with several risk factors. Further prospective studies on a larger group of PD patients are needed to establish a full profile of Polish PD patients with ICDs.

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Section: Discussionsupporting

confidence: 91%

Impulse Control Disorders in the Polish Population of Patients with Parkinson’s Disease

Toś

Grażyńska

Antoniuk³

et al. 2023

Medicina

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“…While treating sleep disorders will likely not affect PD progression, it has the potential for improving NMS and may potentially reduce overall disability and thereby improve the lives of PD patients and their caregivers. 27,28,31 The present study has some limitations. The PDSS is a subjective semiquantitative scale which attempts to provide a holistic and clinical assessment of the complex etiology of sleep problems in PD.…”

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

“…The relationship between sleep problems and ICDs is bidirectional and complex. 28 Sleep disturbances and fragmentation may play a crucial role in increasing susceptibility to impulsive behavior and they may represent a risk factor for developing ICDs in PD patients. On the other hand, ICDs may lead to sleep restriction and fragmentation as well.…”

Section: Discussionmentioning

confidence: 99%

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Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease

Santos‐García

Castro

Fonticoba

et al. 2020

J Geriatr Psychiatry Neurol

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Introduction: The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients. Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. Sleep problems were assessed by the Spanish version of the Parkinson’s disease Sleep Scale version 1 (PDSS-1). An overall score below 82 or a score below 5 on at least 1 item was defined as sleep problems. Results: The frequency of sleep problems was nearly double in PD patients compared to controls: 65.8% (448/681) vs 33.5% (65/206) (p < 0.0001). Mean total PDSS score was lower in PD patients than controls: 114.9 ± 28.8 vs 132.8 ± 16.3 (p < 0.0001). Quality of life (QoL) was worse in PD patients with sleep problems compared to those without: PDQ-39SI, 19.3 ± 14 vs 13 ± 11.6 (p < 0.0001); EUROHIS-QoL8, 3.7 ± 0.5 vs 3.9 ± 0.5 (p < 0.0001). Non-motor symptoms burden (NMSS; OR = 1.029; 95%CI 1.015–1.043; p < 0.0001) and impulse control behaviors (QUIP-RS; OR = 1.054; 95%CI 1.009–1.101; p = 0.018) were associated with sleep problems after adjustment for age, gender, disease duration, daily equivalent levodopa dose, H&Y, UPDRS-III, UPDRS-IV, PD-CRS, BDI-II, NPI, VAS-Pain, VAFS, FOGQ, and total number of non-antiparkinsonian treatments. Conclusion: Sleep problems were frequent in PD patients and were related to both a worse QoL and a greater non-motor symptoms burden in PD. These findings call for increased awareness of sleep problems in PD patients.

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“…Several studies have investigated the relationship between RBD and ICDs . However, the results have been controversial.…”

Section: Introductionmentioning

confidence: 99%

Cross‐sectional and longitudinal associations between probable rapid eye movement sleep behavior disorder and impulse control disorders in Parkinson’s disease

Cao

Chen

Xing

et al. 2020

Euro J of Neurology

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Background and purpose: The aim was to investigate whether probable rapid eye movement sleep behavior disorder (pRBD) is associated with impulse control disorders (ICDs) in drug-na€ ıve patients with Parkinson's disease (PD) and whether baseline pRBD is associated with a higher incidence of ICDs during follow-up. Methods: The Parkinson's Progression Markers Initiative is an international, multicenter, prospective cohort study to identify biomarkers of PD progression. In all, 423 drug-na€ ıve patients with early-stage PD were included in the cross-sectional analysis, and 320 patients who screened negative for any ICDs or related behaviors at baseline were included in the longitudinal analysis. Results: In the cross-sectional analysis, a significant correlation was found between pRBD and ICDs in drug-na€ ıve patients whilst controlling for potential confounders [odds ratio 2.56, 95% confidence interval (CI) 1.38-4.76, P = 0.003]. In the longitudinal analysis, baseline pRBD was an independent predictor of ICD development over time [hazard ratio (HR) 1.648, 95% CI 1.054-2.576; P = 0.028]. Other significant predictors of ICDs included younger age of onset (HR = 0.973, 95% CI = 0.950-0.997; P = 0.026) and greater State-Trait Anxiety Inventory score (HR = 1.040, 95% CI = 1.020-1.061; P < 0.001). Conclusion: Our data suggest that identifying baseline pRBD in early-stage PD may help clinicians to choose a better therapeutic strategy so as to prevent or limit neuropsychiatric complications.

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Sleep in Parkinson’s Disease with Impulse Control Disorder

Cited by 9 publications

References 124 publications

Impulse Control Disorders in the Polish Population of Patients with Parkinson’s Disease

Impulse Control Disorders in the Polish Population of Patients with Parkinson’s Disease

Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease

Cross‐sectional and longitudinal associations between probable rapid eye movement sleep behavior disorder and impulse control disorders in Parkinson’s disease

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