Sleep in Patients with Neurologic and Psychiatric Disorders

Hoyt, Brian

doi:10.1016/j.pop.2005.02.013

Cited by 27 publications

(20 citation statements)

References 24 publications

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“…Although autonomic or olfactory dysfunctions, psychiatric symptoms and sleep disorders may represent prodromal markers of PD, it should be pointed out that none of these symptoms is specific to PD, since they all may occur as idiopathic disorders or during the course of other neurodegenerative diseases, such as Alzheimer’s dementia (Idiaquez et al 2002; Hoyt 2005; Burgut et al 2006; Hawkes 2006). Thus, the identification of pre-motor signs in subjects at risk to develop PD needs to be associated with instrumental evidence of the damage to dopamine nigrostriatal pathway in order to make a correct presymptomatic diagnosis of the disease.…”

Section: Biomarkersmentioning

confidence: 99%

Prodromal non-motor symptoms of Parkinson's disease

Pellicano

Benincasa

Pisani

et al. 2007

Neuropsychiatric Disease and Treatment

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The motor symptoms of Parkinson’s disease (PD), bradykinesia, muscular rigidity, and tremor depend upon degeneration of the dopaminergic neurons in the substantia nigra pars compacta. Recent neuropathological studies show that the Lewy bodies, the intraneuronal landmark of PD, accumulate in several neuronal cell types in the brain. An ascending gradient of pathological involvement, from the medulla oblongata to neocortical areas has been reported. Thus the original view of PD as a disease characterized by selective damage of the dopaminergic neurons in the mesencephalon should be updated into the concept of a severe multisystemic neurodegenerative disorder. Additionally, the neuropathological alterations outside the substantia nigra are soundly correlated with the non-motor symptoms of PD. As a result of these findings, interest is growing in the identification of prodromal non-motor symptoms of PD. Indeed, data from the literature suggest that autonomic disturbances, olfactory dysfunctions, depression and sleep disorders (in particular REM-sleep behavior disorder) may represent prodromal non-motor symptoms of PD. Several tests are available to detect most of these symptoms. Thus, the identification of prodromal non-motor symptoms may contribute to the precocious diagnosis of PD, and might be useful in the future to test the efficacy of neuroprotective agents.

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Section: Biomarkersmentioning

confidence: 99%

Prodromal non-motor symptoms of Parkinson's disease

Pellicano

Benincasa

Pisani

et al. 2007

Neuropsychiatric Disease and Treatment

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“…As many neurodegenerative and psychiatric disorders disrupt sleep–wake cycles (25, 26), these two medicines might help to maintain the amplitude intensity of sleep–wake cycles in patients with the disorders. Saiko is used to treat insomnia previously (22), because the ability of Saiko promotes daytime wakefulness in humans.…”

Section: Discussionmentioning

confidence: 99%

Effects of Kamikihito and Unkei-to on Sleep Behavior of Wild Type and Parkinson Model in Drosophila

Ito¹,

Kawasaki²,

Suzuki³

et al. 2017

Front. Psychiatry

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Parkinson’s disease (PD) is the second most common neurodegenerative disease, and it is associated with sleep behavior disorders. In Drosophila melanogaster disease model, human α-synuclein A30P overexpressing flies (A30P PD model) have been shown for levy body aggregation and movement disorders. We measured sleep rhythms in the A30P PD model flies using the Drosophila Activity Monitoring system and found that they develop sleep defects at 20 days after eclosion. Furthermore, the total amount of sleep is significantly reduced in middle-aged PD model flies and the reduction has been attributed to nighttime sleep. The number and length of sleep bouts also decreased in middle-aged A30P PD model flies. Feeding of the oriental traditional herbal medicines (Kampo), Kamikihito and Unkei-to significantly ameliorate the level of sleep defects in A30P PD model flies. The Kamikihito and Unkei-to recovered 60-min sleep bouts number in the A30P PD model flies to the level of young (5 days after eclosion) flies. Kamikihito recovered sleep both in wild-type and PD model flies. Unkei-to ameliorates not only sleep but also motor function in PD model flies. The data suggest that Kamikihito and Unkei-to might be useful for the sleep defects in human PD patients as well as healthy human.

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“…Sufferers may variably exhibit persisting positive, negative, cognitive, affective and excited symptoms, suicidal ideation, impoverished social function, unusual or personally maladaptive behaviours, and demonstrate impairments in social role function and vocation [43]. Sleep problems are commonly seen in patients with schizophrenia with 80 % of hospitalised schizophrenic patients having some form of sleep disorder [44]. A meta-analysis on untreated schizophrenia summarised the co-existing sleep problems of increased sleep latency, reduced total sleep time and reduced sleep efficiency [45].…”

Section: Osa and Schizophreniamentioning

confidence: 99%

Sleep-Disordered Breathing and Psychiatric Disorders

Naqvi

Wang

Glozier

et al. 2014

Curr Psychiatry Rep

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Sleep-disordered breathing, the commonest form of which is obstructive sleep apnoea (OSA) is increasingly recognised as a treatable cause of morbidity. It shares many risk factors with psychiatric disorders including behaviours such as smoking and physical comorbidity. Many symptoms of the two overlap, leaving OSA often undetected and undertreated. In the few studies that assess the two, OSA is commonly comorbid with depression (17-45%) and schizophrenia (up to 55%) and possibly bipolar. There is some limited evidence that treating OSA can ameliorate psychiatric symptoms. Some psychotropics, such as narcotics, cause sleep-disordered breathing (SDB), whilst weight-inducing neuroleptics may exacerbate it. An extreme form of SDB, sudden infant death syndrome (SIDS), is a risk in mothers with substance abuse. Being aware of these common comorbidities may help improve psychiatric patient's treatment and quality of life.

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Sleep in Patients with Neurologic and Psychiatric Disorders

Cited by 27 publications

References 24 publications

Prodromal non-motor symptoms of Parkinson's disease

Prodromal non-motor symptoms of Parkinson's disease

Effects of Kamikihito and Unkei-to on Sleep Behavior of Wild Type and Parkinson Model in Drosophila

Sleep-Disordered Breathing and Psychiatric Disorders

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