Sleep in patients with Parkinson's disease and its influence by l-DOPA

Schneider, Elke; Maxion, H; Ziegler, Benjamin; Jacobi, Pedro Roberto

doi:10.1007/bf00594087

Cited by 14 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Solche unterschiedlichen Effekte einer Substanz auf den REM-Schlaf sind z.B. von L-Dopa bekannt, das bei Parkinsonkranken ganz andere Veranderungen der Schlafparameter, namlich so-wohl eine Zunahme des REM-als auch orthodoxen Schlafes bei entsprechender positiver Beeinflussung der klinischen Symptomatik hervorruft (Kendel et al, 1972;Schneider et al, 1974) als etwa bei Gesunden oder Depressiven. Allerdings zeigt die Substanz den REMdeprivatorischen Effekt auch dann.noch an, wenn die Gesamtmenge des REM-Schlafes zunimmt, namlich durch eine Verlangerung der REM-Latenz und einen REM-Rebound in der zweiten Nachthalfte.…”

Section: Diskussionunclassified

Der Einfluß von Sulpirid auf den Schlaf Ergebnisse kontinuierlicher EEG-Untersuchungen

Schneider¹,

Ziegler²,

Maxion³

et al. 1975

Pharmacopsychiatry

Self Cite

View full text Add to dashboard Cite

Short and long term effects of sulpirid on the sleep EEG in humans were investigated in 8 patients aged 20-68 years (average 40.4) suffering from autonomic instability. In each patient seven polygraphic night sleep recording were performed. After an adaption night and two nights without medication each subject got 200-400 mg sulpirid i.m. for two days and then 300-600 mg orally for a three-week period. In both groups the short-term application of sulpirid caused a reduction of waking periods and a slight decrease of stage 3, while stage 2 was increased. In psychotic patients the long-term orally administered substance was followed by an increase of deep synchronous sleep (stage 4). As this alteration of sleep couldn't be revealed in the control group, we consider this finding as a result of the improvement of psychosis. In the patient group the amount of REM sleep was augmented during the short-term application as well as during the long-term application, where, as in the control group the amount of REM sleep decreased when sulpirid was given orally for three weeks. This result is discussed in comparison with the properties of the tricyclic antidepressant drugs and monoamine oxidase inhibitors and the clinical effects of sulpiride.

show abstract

Section: Diskussionunclassified

Der Einfluß von Sulpirid auf den Schlaf Ergebnisse kontinuierlicher EEG-Untersuchungen

Schneider¹,

Ziegler²,

Maxion³

et al. 1975

Pharmacopsychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Parkinson's disease (PD) patients complain of sleep disorders more often than a normal population of the same age group; the reported prevalence being as high as 70% (Kales et al, 1971;Nausieda et al, 1984;Lees et al, 1988). The causes of sleep disorders are multifactorial: disturbances of sleeping regulation and architecture, drug-induced sleep disorders and impairment of motor function (April, 1966;Kales el al., 1971;Schneider et al, 1974;Moskovitz et al, 1978;Scharf et al, 1978;Laihinen et al, 1987;Factor et al, 1990). Sleep related respiratory disturbances such as central or obstructive sleep apneas effect sleep quality in PD (Guilleminault er al., 1977;McNicholas et al, 1983;Apps et al, 1985;Aloe et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Sleep related breathing disturbances and nocturnal akinesia in Parkinson's disease patients: a cross section study

Schwalen

Leclaire

Rechlin

et al. 1997

Euro J of Neurology

View full text Add to dashboard Cite

We studied the occurrence of sleep related breathing disturbances (SRBD) and nocturnal akinesia in patients with Parkinson's Disease (PD) and evaluated the likelihood that PD symptoms consistently influence these sleep disorders. Ninety-two PD patients (mean age 69 years; mean Webster rating score 13) were studied. An ambulatory sleep disorder screening device (hIESAM4) was used to measure oxygen saturation, heart rate, snoring sounds and body position during sleep. Sleep related breathing disturbance (SRBD) was diagnosed if typical cyclic oxygen desaturations > 4% more than 10 times/h were recorded. A nocturnal akinesia was diagnosed if there were < 0.3 changes of body positions/hour or a maximal time in one position of more than 4.3 h. There was evidence of SRBD in 17% of PD patients. SRBD correlated positively with high rigidity and bradykinesia scores as well as high Webster rating scale scores and age of men. Thirty percent of PD patients had an objective nocturnal akinesia. This was also combined with a high rigidity score. No relation between SRBD or Nocturnal akinesia, L-Dopa intake, duration of the disease or onset of the disease was found.

show abstract

Schlafstörungen bei neurologischen Erkrankungen

Meier-Ewert¹

1990

Schlaf Und Schlafstörungen

View full text Add to dashboard Cite

Sleep in patients with Parkinson's disease and its influence by l-DOPA

Cited by 14 publications

References 19 publications

Der Einfluß von Sulpirid auf den Schlaf Ergebnisse kontinuierlicher EEG-Untersuchungen

Der Einfluß von Sulpirid auf den Schlaf Ergebnisse kontinuierlicher EEG-Untersuchungen

Sleep related breathing disturbances and nocturnal akinesia in Parkinson's disease patients: a cross section study

Schlafstörungen bei neurologischen Erkrankungen

Contact Info

Product

Resources

About