Sleep induced by small doses of tubocurarine injected into cerebral ventricles of dog

Haranath, P. S. R. K.; S, Shyamalakumari

doi:10.1111/j.1476-5381.1973.tb08264.x

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…The present study supports the suggestion of Haranath & Shyamalakumari (1973) that the site for induction of sleep by small amounts of (+)-tubocurarine injected into the body of the lateral ventricle is in the structures lining the inferior horn. Tubocurarine, even in 10-20 ng doses injected in a 5 gl volume into the inferior horn produced sleep, whereas 500 ng tubocurarine was required to induce sleep when injected into the body of the lateral ventricles.…”

Section: Discussionsupporting

confidence: 91%

Section: Cholinolytic Drugsmentioning

confidence: 99%

“…The same doses of 10-20 ng tubocurarine did not produce any effect when given into the body of the lateral ventricle. The injection of 500 ng (+)-tubocurarine into the body of the lateral cerebral ventricle was required to produce sleep (Haranath & Shyamalakumari, 1973). That the inferior horn is a site for induction of sleep was borne out not only with (+)-tubocurarine but by the cholinomimetic drugs like acetylcholine, physostigmine, pilocarpine and nicotine, and by the acetylcholine antagonists, atropine, hyoscine and hexamethonium.…”

Section: Observationsmentioning

confidence: 99%

“…Methods Haranath & Shyamalakumari (1973) described sleep following tubocurarine injected into the lateral ventricle in small doses (500 ng) or perfused in low concentration (10 ng/min) through the cerebral ventricles. They postulated that the site for induction of sleep could be in the structures lining the inferior horn of the lateral cerebral ventricles.…”

Section: Introductionmentioning

confidence: 99%

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Sleep Induced by Drugs Injected Into the Inferior Horn of the Lateral Cerebral Ventricle in Dogs

Haranath

Venkatakrishna‐Bhatt

1977

British J Pharmacology

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I In unanaesthetized dogs, cholinomimetic drugs and their antagonists were injected into the inferior horn of the left lateral cerebral ventricle. Injection volumes of 5 1l were used to limit spread of the drugs beyond the inferior horn. The effects on EEG and behaviour were recorded and compared with the effects of the same doses given into the body of the right lateral ventricle a little behind the foramen of Monro.2 Injections of cholinomimetic drugs into the inferior horn (acetylcholine 1-2 jg, physostigmine 1.0 gg, pilocarpine 100 gig and nicotine 10 jg) induced sleep during the following hour. The same doses injected into the body of the lateral ventricle did not produce sleep.3 Cholinolytic drugs (atropine 10-20 jig, hyoscine 0.4-1.6 gg, (±)tubocuraine 10-20 ng and hexamethonium 40 jig) injected into the inferior horn also produced sleep, but the same doses injected into the body of the lateral ventricle were without effect. The EEG recorded after tubocurarine showed high voltage slow waves during sleep and desynchronized activation during rapid eye movement sleep. 4 Noradrenaline (10 jg) injected into the inferior horn produced sleep whereas the same dose given into the body of lateral ventricle did not produce sleep. The results with 5-hydroxytryptamine were equivocal. 5 It is suggested that the site for induction of sleep lies in structures lining the inferior horn of the lateral cerebral ventricle and that the cholinomimetic drugs probably act by a depolarizing block and the acetlycholine antagonists by a competitive block.

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Section: Discussionsupporting

confidence: 91%

Section: Cholinolytic Drugsmentioning

confidence: 99%

Section: Observationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sleep Induced by Drugs Injected Into the Inferior Horn of the Lateral Cerebral Ventricle in Dogs

Haranath

Venkatakrishna‐Bhatt

1977

British J Pharmacology

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“…leads to it appearing in the cerebrospinal fluid. The concentration in the cerebrospinal fluid reaches up to an equivalent of 0.75 \i% ml" 1 in man and 1 fig ml" 1 in dog (Haranath et al, 1973). Whether an impaired blood-brain barrier increases the passage and whether the increased passage may be of neural consequence are unclear.…”

Section: Passage Of Muscle Relaxants Into the Cerebrospinal Fluidmentioning

confidence: 99%