Sleep is increased in mice with obesity induced by high-fat food

Jenkins, Joe B.; Omori, Takenori; Guan, Zhonghong; Vgontzas, Alexandros N.; Bixler, Edward O.; Fang, Jidong

doi:10.1016/j.physbeh.2005.10.010

Cited by 98 publications

(96 citation statements)

References 46 publications

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“…In general, our results agreed with earlier studies that evaluated the sleep/wakefulness profiles of HFD-induced obese C57BL/6 mice with a similar degree of weight gain [13,14].…”

Section: Discussionsupporting

confidence: 92%

“…HFD is also known to affect postprandial sleepiness in humans [12]. Similarly, obese mice fed a HFD for 6 weeks experience increased NREM sleep and sleep fragmentation [13,14], and their sleep/wakefulness phenotype is quite similar to that of genetically obese ob/ob [7] and db/db [8] mice. The hypothalamic orexin level is also affected in HFD-induced obesity model animals, although reports differ.…”

Section: Introductionmentioning

confidence: 99%

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Hypothalamic prepro-orexin mRNA level is inversely correlated to the non-rapid eye movement sleep level in high-fat diet-induced obese mice

Tanno

Terao

Okamatsu‐Ogura

et al. 2013

Obesity Research & Clinical Practice

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Orexins are hypothalamic neuropeptides, which play important roles in the regulation and maintenance of sleep/wakefulness states and energy homeostasis. To evaluate whether alterations in orexin system is associated with the sleep/wakefulness abnormalities observed in obesity, we examined the mRNA expression of prepro-orexin, orexin receptor type 1, (orexin 1r), and orexin receptor type 2 (oxexin 2r) in the hypothalamus in mice fed with a normal diet (ND) and high-fat diet (HFD)-induced obese mice. We also compared their relationships with sleep/wakefulness. Twenty-four, 4-week-old, male C57BL/6J mice were divided randomly into 3 groups, which received the following: (1) ND for 17 weeks; (2) HFD for 17 weeks; and (3) ND for 7 weeks and HFD for a further 10 weeks. The body weights of mice fed the HFD for 10-17 weeks were 112-150% of the average body weight of the ND group. The daily amount of non-rapid eye movement (NREM) sleep increased significantly in HFD-fed mice. These changes were accompanied by increases in the number but decreases in the duration of each NREM sleep episode. In addition, brief awakenings (<20 s epoch) during NREM sleep was nearly 2-fold more frequent. The mRNA level of prepro-orexin in the hypothalamus was significantly reduced in HFD-induced obese 3 mice, whereas the levels of orexin 1r and orexin 2r were unaffected. The daily amount of NREM sleep was negatively correlated with the hypothalamic prepro-orexin mRNA level, so these results suggest that the increased NREM sleep levels in HFD-induced obese mice are attributable to impaired orexin activity.

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“…In general, our results agreed with earlier studies that evaluated the sleep/wakefulness profiles of HFD-induced obese C57BL/6 mice with a similar degree of weight gain [13,14].…”

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Hypothalamic prepro-orexin mRNA level is inversely correlated to the non-rapid eye movement sleep level in high-fat diet-induced obese mice

Tanno

Terao

Okamatsu‐Ogura

et al. 2013

Obesity Research & Clinical Practice

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“…Rogers et al 19 reported no difference in body weight or fat mass of wheel-running chow-fed female C57BL/6J mice compared with non-running controls. However, Jenkins et al 8 observed that HF-fed mice increased not only their body weight but also their sleep time.…”

Section: Discussionmentioning

confidence: 99%

“…4 Disordered sleep may also be a risk factor for metabolic syndrome in both children and adults. 5,6 However, excessive daytime sleepiness is thought to relate to obesity independently of sleep-disordered breathing, 7 and recent studies have linked increased body weight in mice with increased sleep, 8 particularly during the dark period when mice are usually more active (an observation that the authors made in comparison with human daytime sleepiness).…”

Section: Introductionmentioning

confidence: 99%

Wheel running in female C57BL/6J mice: impact of oestrus and dietary fat and effects on sleep and body mass

2009

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Objective: To examine the impact of two diets differing in fat content and of wheel-running exercise on body mass. Methods: A total of 32 female C57BL/6J mice were assigned to either a high-fat (HF, 41% of dietary energy as fat) or low-fat (LF, 11% of dietary energy as fat) diet (16 per diet, individually housed). Eight mice from each diet group were housed with running wheels. Non-running mice were housed in similar cages, without wheels. Total cage activity (including non-exercise physical activity þ wheel running) and sleep time were also measured using an infra-red-sensing device. Oestrus stage of the wheel-running mice was assessed daily for 17 days. Results: After 8 weeks, HF mice were significantly heavier than LF mice (P ¼ 0.004), but there was no detectable difference in body fat mass. Wheel-running mice tended to have a lower body mass than non-running controls (P ¼ 0.056). Voluntary cage activity was greater in LF control mice than HF control mice, and in wheel-running mice compared with non-wheel-running mice. HF control mice slept more than LF control mice. Stage of oestrus was significantly correlated with running distance, with mice running farthest in the immediate preoestrus phase and least immediately after oestrus. Conclusion: This study shows that HF diets in female C57BL/6J mice may increase sleep time similar to the effect of daytime sleepiness observed in obese humans.

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“…Alternatively SWS was promoted by elevation of fat oxidation. Jenkins et al examined the effects of high fatinduced obesity on sleep in mice, in which the increases of NREM sleep were positively correlated with the increases in the body weight (25). However, the highfat feeding had an acute effect on NREM sleep before the development of obesity, suggesting that sleep responses to food intake were related to enhanced oxidation of fat rather than the increases in the body weight.…”

Section: Discussionmentioning

confidence: 99%

Effects of Nutrient Composition of Dinner on Sleep Architecture and Energy Metabolism during Sleep

Yajima

Seya

Iwayama

et al. 2014

J Nutr Sci Vitaminol

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Summary Energy metabolism and substrate oxidation during sleep correlate with sleep stage, suggesting that energy metabolism affects sleep architecture or vice versa. The aim of the present study was to examine whether changes in energy metabolism during sleep, induced by a high-carbohydrate or high-fat meal for dinner, affect sleep architecture. Ten healthy males participated in this study, sleeping 3 nonconsecutive nights in a whole-room calorimeter. The first night was scheduled as an adaptation to the experimental environment. The other 2 nights were experimental calorimetry in a balanced cross-over design with intrasubject comparisons. In each session, subjects comsumed a high carbohydrate (HCD: PFC510 : 10 : 80) or high fat (HFD: PFC510 : 78 : 12) meal at 2000 h and slept with a polysomnographic recording in a metabolic chamber for indirect calorimetry (0000 h to 0800 h). Slow wave sleep was decreased during the first sleep cycle and not changed during the second or third sleep cycle under HCD conditions compared with those of HFD. Energy expenditure was not affected by dietary condition but substrate oxidation reflected differences in dietary composition of the dinner during the first and second sleep cycle. The present study suggested the possibility that substrate availability during sleep affects substrate oxidation during sleep, and affects sleep architecture during the first sleep cycle.

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Sleep is increased in mice with obesity induced by high-fat food

Cited by 98 publications

References 46 publications

Hypothalamic prepro-orexin mRNA level is inversely correlated to the non-rapid eye movement sleep level in high-fat diet-induced obese mice

Hypothalamic prepro-orexin mRNA level is inversely correlated to the non-rapid eye movement sleep level in high-fat diet-induced obese mice

Wheel running in female C57BL/6J mice: impact of oestrus and dietary fat and effects on sleep and body mass

Effects of Nutrient Composition of Dinner on Sleep Architecture and Energy Metabolism during Sleep

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