Sleep, lung function, and quality of life in patients with myasthenia gravis: A cross-sectional study

Oliveira, Ezequiel Fernandes; Nacif, Sérgio Roberto; Urbano, Jéssica Julioti; Silva, Anderson Soares; Oliveira, Cláudia Santos; Perez, Eduardo Araújo; Polaro, Melissa Nunes; Valério, Berenice Cataldo Oliveira; Stirbulov, Roberto; Insalaco, Giuseppe; Oliveira, Acary; Oliveira, Luís Vicente Franco de

doi:10.1016/j.nmd.2016.11.015

Cited by 25 publications

(13 citation statements)

References 32 publications

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“…We found that lung function was signi cantly associated with REM sleep duration, even after controlling for confounders, suggesting a salient association between lung function and REM sleep. Notably, reductions in measures of lung function measures (maximum ventilatory pressure and FVC) and REM sleep time were also found in myasthenia gravis and lipid storage diseases, but their associations have not been assessed in previous studies [17,18]. In cystic brosis patients, as the disease worsens, blood oxygen levels drop and REM sleep time decreases, and both measures improve with treatment [16].…”

Section: Discussionmentioning

confidence: 99%

“…Conclusion: Our ndings further con rmed that lung function is closely related to sleep architectures in healthy population, particularly, the result for FEV1/FVC is positively correlated with REM sleep. rapid eye movement (REM) sleep time were also found in myasthenia gravis and lipid storage diseases, but their associations have not been examined in previous studies [17, 18]. Although many diseaseoriented studies have shown that lung function and sleep are closely related, but in healthy adults, the relationship between the two remains unclear.…”

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confidence: 99%

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The Associations Between Lung Function And Rapid Eyes Movement Sleep In Healthy Adults: A Population-Based Cohort Study In Southwest China

Peng

Yang

et al. 2022

Preprint

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Background: To explore and understand associations between lung function and sleep architectures in healthy adults. Methods: Seventy-two participants (mean age 55.9 years, 72.2% female) were recruited from the Southwest China cohort study conducted at the West China hospital. Forced expiratory volume in first second (FEV1) and the ratio of FEV1 to forced vital capacity (FEV1/FVC) were measured using a spirometer for all participants. Participants’ objective sleep architectures, including sleep duration, rapid eye movement (REM) time, light and deep sleep were monitored using a Doppler radar sensor. Linear regression was used to analyze the associations between lung function measures and sleep architecture.Results: Results for FEV1/FVC were found to be positively correlated with REM sleep time (β = 0.29, p = 0.013). There was no positive correlation with sleep duration (p = 0.44 ), light sleep (p = 0.83) or deep sleep (p = 0.60) in regression model, including the use of lung function as the only predictor. Results for FEV1 demonstrated a tendency of positive correlation with REM sleep (β = 0.22, p = 0.07 ) and deep sleep (β = 0.21, p = 0.073), but it was not associated with sleep duration (p = 0.53) or light sleep (p = 0.54). After adjusting for all confounders, the results of FEV1/FVC remained positively correlated with REM sleep time (β = 0.28, p = 0.028). Conclusion: Our findings further confirmed that lung function is closely related to sleep architectures in healthy population, particularly, the result for FEV1/FVC is positively correlated with REM sleep.

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Section: Discussionmentioning

confidence: 99%

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The Associations Between Lung Function And Rapid Eyes Movement Sleep In Healthy Adults: A Population-Based Cohort Study In Southwest China

Peng

Yang

et al. 2022

Preprint

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“…Despite the high baseline values, PI max showed a tendency to further increase with RMET. A recent study in 25 MG patients showed that low maximum ventilatory pressures were associated with sleep-disordered breathing and impaired health-related quality of life despite normal VC and FEV1 [39]. Consequently, an improved PI max may indicate benefits for MG patients.…”

Section: Discussionmentioning

confidence: 99%

Effects of long-term respiratory muscle endurance training on respiratory and functional outcomes in patients with Myasthenia gravis

Freitag¹,

Hallebach²,

Baumann³

et al. 2018

Respiratory Medicine

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Background: Myasthenia gravis (MG) is characterized by reduced muscle endurance and often leads to respiratory complications. Objective: A long-term respiratory muscle endurance training (RMET) based on normocapnic hyperpnea was introduced for the first time in MG patients. We investigated RMET effects on respiratory endurance (RE), MG symptoms, lung function and physical fitness and compared the results with a control group (CG). Methods: The training period consisted of four weeks intensive training (IT; five 30-min training sessions per week) followed by twelve months maintenance training (MT; five 30-min training sessions over two weeks). Eighteen patients with mild to moderate MG participated as the training group (TG), six patients served as CG. RE, lung function, MG score and physical fitness were tested before and after IT and after three to twelve months of MT. Results: Only 12 TG patients completed the entire training period. Thirteen months of training significantly increased RE measured as time until exhaustion (T lim ) to 412% of baseline (P < 0.001). The MG score improved from 0.67± 0.09 to 0.41 ± 0.1 (p = 0.004), and the number of squats per minute as a measure of physical fitness increased in the TG to 160% of baseline (p = 0.015). While lung function did not change during the training period, we observed a modulation in the breathing pattern at rest with prolonged expiration (122% of baseline, p = 0.028). In addition, TG reported subjective improvements in MG symptoms, respiratory symptoms and physical fitness by 49%, 58% and 64%, respectively (P < 0.001). No significant changes were observed in the CG. Conclusion and significance: This is the first controlled long-term RMET study in MG patients. The results demonstrated that this normocapnic hyperpnea training is feasible and beneficial for patients with mild to moderate MG and is a valuable supplement to conventional drug treatment.

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“…Following the development and piloting of the STROBE-M score checklist, we conducted a more formal evaluation of its inter-rater agreement. One reviewer (VL) selected 45 observational study publications (15 each from cross-sectional (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37), cohort (38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52), and case-control study (53-67) from ìPubMed databaseî published in the time period of 1 st March 2016 to 31 st May 2016 with the filters of English language, human studies, and full text availability. Irrelevant publications (opinion or critique of previous studies, letters to editors, meta-analysis were excluded (Fig.…”

Section: Inter-rater Agreement Of Strobe-m Score Checklistmentioning

confidence: 99%

Development of a Quantitative Scoring Method for Strobe Checklist

Limaye¹,

Limaye²,

Pitani³

et al. 2018

Acta Poloniae Pharmaceutica - Drug Research

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Evidence-based medicine (EBM) has brought a substantial change in medical practice and clinical care approach (1-3). It has helped to focus on valid and reliable information to make sound decisions in the area of disease management. Although randomized controlled trials (RCTs) are considered as the reference standard and provide valuable evidence about the efficacy of new treatments, yet they do not answer all important questions about the specific treatment. Most of the knowledge in clinical practice comes from observational studies from which we can gain further experience to plan interventional studies in regards to efficacy, safety and tolerability of approved medicines (4). An observational study is defined as a study that provides estimates and examines associations of events in their natural settings without recourse to experimental intervention (5). It includes cohort studies (CO) ñ prospective and retrospective, crosssectional studies (CS), and case-control studies (CC) (6). Current evidence suggests that observational studies, such as those discussed earlier, both com

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Sleep, lung function, and quality of life in patients with myasthenia gravis: A cross-sectional study

Cited by 25 publications

References 32 publications

The Associations Between Lung Function And Rapid Eyes Movement Sleep In Healthy Adults: A Population-Based Cohort Study In Southwest China

The Associations Between Lung Function And Rapid Eyes Movement Sleep In Healthy Adults: A Population-Based Cohort Study In Southwest China

Effects of long-term respiratory muscle endurance training on respiratory and functional outcomes in patients with Myasthenia gravis

Development of a Quantitative Scoring Method for Strobe Checklist

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